Prime

Type your tag names separated by a space and hit enter

Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level.

Abstract

Mangiferin is a phytochemical primarily present in the stem, leaves and bark of Mangifera indica. It offers neuroprotection mainly through inhibition of oxidative stress, and decreasing proinflammatory cytokines level in the brain. Aluminium has been reported to cause oxidative stress-associated damage in the brain. In the present investigation, protective effect of mangiferin against aluminium chloride (AlCl3)-induced neurotoxicity and cognitive impairment was studied in male Swiss albino mice. AlCl3 (100 mg/kg) was administered once daily through oral gavage for 42 days. Mangiferin (20 and 40 mg/kg, p.o.) was given to mice for last 21 days of the study. We found cognitive dysfunction in AlCl3-treated group, which was assessed by Morris water maze test, and novel object recognition test. AlCl3-treated group showed elevated level of oxidative stress markers, proinflammatory cytokines level and lowered hippocampal brain-derived neurotrophic factor (BDNF) content. Mangiferin (40 mg/kg) prevented the cognitive deficits, hippocampal BDNF depletion, and biochemical anomalies induced by AlCl3-treatment. In conclusion, our data demonstrated that mangiferin offers neuroprotection in AlCl3-induced neurotoxicity and it may be a potential therapeutic approach in the treatment of oxido-nitrosative stress and inflammation-associated neurotoxicity.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, Assam 781032, India.

    ,

    Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, Assam 781032, India. Electronic address: ashokjangra123@gmail.com.

    Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, Assam 781032, India; Department of Pharmacology, Gauhati Medical College, Guwahati, Assam 781032, India. Electronic address: dr.lahkarniper@gmail.com.

    Source

    MeSH

    Acetylcholinesterase
    Aluminum Compounds
    Animals
    Behavior, Animal
    Biomarkers
    Brain-Derived Neurotrophic Factor
    Chlorides
    Cholinesterase Inhibitors
    Cytokines
    Dose-Response Relationship, Drug
    GPI-Linked Proteins
    Hippocampus
    Lipid Peroxidation
    Male
    Maze Learning
    Mice
    Nerve Tissue Proteins
    Neurons
    Neuroprotective Agents
    Neurotoxicity Syndromes
    Oxidative Stress
    Random Allocation
    Water Pollutants, Chemical
    Xanthones

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26004900