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Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release.
Carbohydr Polym. 2015 Sep 05; 128:112-21.CP

Abstract

This paper reports the synthesis of magnetic and pH-sensitive beads derived from κ-carrageenan and carboxymethyl chitosan for drug delivery. The magnetic Fe3O4 nanoparticles were synthesized inside a mixture of biopolymers by in situ method. The structural properties of hydrogel beads were characterized by TEM, SEM, XRD, and VSM techniques. The swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Introducing magnetic nanoparticles caused a decrease in swelling capacity from 16.4 to 10 g/g. Drug loading and release efficiency were investigated using diclofenac sodium as a model system. The in vitro drug release studies exhibited significant behaviors on the subject of physiological simulated pHs and external alternative magnetic fields. The maximum cumulative release was around 82% at pH 7.4. The presence of magnetite nanoparticles certainly influenced the drug release patterns. The response of beads to external stimulus makes them as good candidates for novel drug delivery systems.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Mahdavinia GR
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran. Electronic address: grmnia@maragheh.ac.ir.
Etemadi H
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.
Soleymani F
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111 Maragheh, Iran.

MeSH

Anti-Inflammatory Agents, Non-SteroidalCarrageenanChitosanDelayed-Action PreparationsDiclofenacDrug LiberationHydrogelsHydrogen-Ion ConcentrationMagnetic PhenomenaMagnetite Nanoparticles

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26005146

Citation

Mahdavinia, Gholam Reza, et al. "Magnetic/pH-responsive Beads Based On Caboxymethyl Chitosan and Κ-carrageenan and Controlled Drug Release." Carbohydrate Polymers, vol. 128, 2015, pp. 112-21.
Mahdavinia GR, Etemadi H, Soleymani F. Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release. Carbohydr Polym. 2015;128:112-21.
Mahdavinia, G. R., Etemadi, H., & Soleymani, F. (2015). Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release. Carbohydrate Polymers, 128, 112-21. https://doi.org/10.1016/j.carbpol.2015.04.022
Mahdavinia GR, Etemadi H, Soleymani F. Magnetic/pH-responsive Beads Based On Caboxymethyl Chitosan and Κ-carrageenan and Controlled Drug Release. Carbohydr Polym. 2015 Sep 5;128:112-21. PubMed PMID: 26005146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release. AU - Mahdavinia,Gholam Reza, AU - Etemadi,Hossein, AU - Soleymani,Fatemeh, Y1 - 2015/04/21/ PY - 2014/01/11/received PY - 2015/03/30/revised PY - 2015/04/01/accepted PY - 2015/5/26/entrez PY - 2015/5/26/pubmed PY - 2016/2/24/medline KW - Bead KW - Carboxymethyl chitosan KW - Controlled release KW - Magnetic KW - κ-Carrageenan SP - 112 EP - 21 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 128 N2 - This paper reports the synthesis of magnetic and pH-sensitive beads derived from κ-carrageenan and carboxymethyl chitosan for drug delivery. The magnetic Fe3O4 nanoparticles were synthesized inside a mixture of biopolymers by in situ method. The structural properties of hydrogel beads were characterized by TEM, SEM, XRD, and VSM techniques. The swelling ratio of beads indicated pH-dependent properties with maximum water absorbing at pH 7.4. Introducing magnetic nanoparticles caused a decrease in swelling capacity from 16.4 to 10 g/g. Drug loading and release efficiency were investigated using diclofenac sodium as a model system. The in vitro drug release studies exhibited significant behaviors on the subject of physiological simulated pHs and external alternative magnetic fields. The maximum cumulative release was around 82% at pH 7.4. The presence of magnetite nanoparticles certainly influenced the drug release patterns. The response of beads to external stimulus makes them as good candidates for novel drug delivery systems. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/26005146/Magnetic/pH_responsive_beads_based_on_caboxymethyl_chitosan_and_κ_carrageenan_and_controlled_drug_release_ DB - PRIME DP - Unbound Medicine ER -