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Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA).
Int J Cardiol 2015; 193:64-8IJ

Abstract

BACKGROUND/OBJECTIVES

Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function.

METHODS

MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables.

RESULTS

Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m(2)), LV end diastolic volume index (LVEDVi) (-7 ml/m(2)), LV end systolic volume index (LVESVi) (-3 ml/m(2)) and stroke volume (-5 ml) (all p≤0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3g/m(2)), LVEDVi (-1.5 ± 0.4 ml/m(2)), LVESVi (-0.7 ± 0.2 ml/m(2)) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05).

CONCLUSIONS

Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.

Authors+Show Affiliations

Northwestern University Feinberg School of Medicine, Chicago, IL, United States.Northwestern University Feinberg School of Medicine, Chicago, IL, United States.University of California, San Diego, CA, United States.Johns Hopkins University School of Medicine, Baltimore, MD, United States.Johns Hopkins University School of Medicine, Baltimore, MD, United States.Johns Hopkins University School of Medicine, Baltimore, MD, United States.Northwestern University Feinberg School of Medicine, Chicago, IL, United States.Northwestern University Feinberg School of Medicine, Chicago, IL, United States. Electronic address: p-greenland@northwestern.edu.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26005181

Citation

Sharma, Shishir, et al. "Association of Serum Leptin With Future Left Ventricular Structure and Function: the Multi-Ethnic Study of Atherosclerosis (MESA)." International Journal of Cardiology, vol. 193, 2015, pp. 64-8.
Sharma S, Colangelo LA, Allison MA, et al. Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2015;193:64-8.
Sharma, S., Colangelo, L. A., Allison, M. A., Lima, J. A., Ambale-Venkatesh, B., Kishi, S., ... Greenland, P. (2015). Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA). International Journal of Cardiology, 193, pp. 64-8. doi:10.1016/j.ijcard.2015.05.068.
Sharma S, et al. Association of Serum Leptin With Future Left Ventricular Structure and Function: the Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2015 Aug 15;193:64-8. PubMed PMID: 26005181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA). AU - Sharma,Shishir, AU - Colangelo,Laura A, AU - Allison,Matthew A, AU - Lima,Joao A C, AU - Ambale-Venkatesh,Bharath, AU - Kishi,Satoru, AU - Liu,Kiang, AU - Greenland,Philip, Y1 - 2015/05/14/ PY - 2015/05/05/received PY - 2015/05/11/accepted PY - 2015/5/26/entrez PY - 2015/5/26/pubmed PY - 2016/3/10/medline KW - Adipokine KW - Cardiac structure KW - Left ventricular mass KW - Leptin SP - 64 EP - 8 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 193 N2 - BACKGROUND/OBJECTIVES: Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. METHODS: MESA is a multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. RESULTS: Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14 g), LV mass index (-9 g/m(2)), LV end diastolic volume index (LVEDVi) (-7 ml/m(2)), LV end systolic volume index (LVESVi) (-3 ml/m(2)) and stroke volume (-5 ml) (all p≤0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5 g ± 0.7 g), LV mass index (-1.7 ± 0.3g/m(2)), LVEDVi (-1.5 ± 0.4 ml/m(2)), LVESVi (-0.7 ± 0.2 ml/m(2)) and stroke volume (-1.0 ± 0.5 ml) (all p ≤ 0.05). CONCLUSIONS: Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/26005181/Association_of_serum_leptin_with_future_left_ventricular_structure_and_function:_The_Multi_Ethnic_Study_of_Atherosclerosis__MESA__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(15)01123-7 DB - PRIME DP - Unbound Medicine ER -