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Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania.
Ecotoxicol Environ Saf. 2015 Sep; 119:198-205.EE

Abstract

Pollution of the aquatic environment by heavy metals is a great concern worldwide. Freshwater fish ingests various metals through gills, skin or diet. Our aim was to investigate the oxidative stress and histopathological injuries induced by Fe, Cu, Zn, Pb, Cd in the liver and kidney of Leuciscus cephalus. Fish samples were collected from two sites in the Tur River, NW Romania, in upstream and downstream of a pollution source. Metals were differently distributed in the liver and kidney of fish. The highest concentrations of Fe, Cu and Pb were found in liver, whereas Zn and Cd concentrations were the highest in kidney in specimens collected from the downstream site. The histopathological changes were associated with metal bioaccumulation, being more severe in kidney than liver. Malondialdehyde (MDA) and advanced oxidation protein products (AOPP) increased significantly in the liver and kidney of fish from downstream site compared to upstream one, whereas reduced glutathione (GSH) decreased. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) increased significantly in livers, whereas SOD increased in kidney. Our study revealed that liver has a higher capacity and adaptability to counteract ROS compared to kidney. The more pronounced increase of hepatic SOD, CAT and GST activities is related milder structural changes observed in liver compared to kidney, where lesions were not reduced by antioxidant defense system.

Authors+Show Affiliations

Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania. Electronic address: anca.hermenean@gmail.com.Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania; Medical Laboratory Service Synevo, 18 Creanga, Medgidia, Romania.Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.Department of Biology, Faculty of Natural Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania.Department of Applied Chemistry, University of Debrecen, H-4032 Debrecen, Hungary.Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4032, Debrecen, Hungary.Department of Applied Chemistry, University of Debrecen, H-4032 Debrecen, Hungary.Department of Applied Chemistry, University of Debrecen, H-4032 Debrecen, Hungary.Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26005919

Citation

Hermenean, Anca, et al. "Histopatological Alterations and Oxidative Stress in Liver and Kidney of Leuciscus Cephalus Following Exposure to Heavy Metals in the Tur River, North Western Romania." Ecotoxicology and Environmental Safety, vol. 119, 2015, pp. 198-205.
Hermenean A, Damache G, Albu P, et al. Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania. Ecotoxicol Environ Saf. 2015;119:198-205.
Hermenean, A., Damache, G., Albu, P., Ardelean, A., Ardelean, G., Puiu Ardelean, D., Horge, M., Nagy, T., Braun, M., Zsuga, M., Kéki, S., Costache, M., & Dinischiotu, A. (2015). Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania. Ecotoxicology and Environmental Safety, 119, 198-205. https://doi.org/10.1016/j.ecoenv.2015.05.029
Hermenean A, et al. Histopatological Alterations and Oxidative Stress in Liver and Kidney of Leuciscus Cephalus Following Exposure to Heavy Metals in the Tur River, North Western Romania. Ecotoxicol Environ Saf. 2015;119:198-205. PubMed PMID: 26005919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania. AU - Hermenean,Anca, AU - Damache,Georgiana, AU - Albu,Paul, AU - Ardelean,Aurel, AU - Ardelean,Gavril, AU - Puiu Ardelean,Doru, AU - Horge,Monica, AU - Nagy,Tibor, AU - Braun,Mihály, AU - Zsuga,Miklós, AU - Kéki,Sándor, AU - Costache,Marieta, AU - Dinischiotu,Anca, Y1 - 2015/05/25/ PY - 2015/02/05/received PY - 2015/05/16/revised PY - 2015/05/18/accepted PY - 2015/5/26/entrez PY - 2015/5/26/pubmed PY - 2016/2/3/medline KW - Leuciscus cephalus KW - Liver and kidney KW - Oxidative stress KW - eavy metals bioaccumulation KW - istopathology SP - 198 EP - 205 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 119 N2 - Pollution of the aquatic environment by heavy metals is a great concern worldwide. Freshwater fish ingests various metals through gills, skin or diet. Our aim was to investigate the oxidative stress and histopathological injuries induced by Fe, Cu, Zn, Pb, Cd in the liver and kidney of Leuciscus cephalus. Fish samples were collected from two sites in the Tur River, NW Romania, in upstream and downstream of a pollution source. Metals were differently distributed in the liver and kidney of fish. The highest concentrations of Fe, Cu and Pb were found in liver, whereas Zn and Cd concentrations were the highest in kidney in specimens collected from the downstream site. The histopathological changes were associated with metal bioaccumulation, being more severe in kidney than liver. Malondialdehyde (MDA) and advanced oxidation protein products (AOPP) increased significantly in the liver and kidney of fish from downstream site compared to upstream one, whereas reduced glutathione (GSH) decreased. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) increased significantly in livers, whereas SOD increased in kidney. Our study revealed that liver has a higher capacity and adaptability to counteract ROS compared to kidney. The more pronounced increase of hepatic SOD, CAT and GST activities is related milder structural changes observed in liver compared to kidney, where lesions were not reduced by antioxidant defense system. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/26005919/Histopatological_alterations_and_oxidative_stress_in_liver_and_kidney_of_Leuciscus_cephalus_following_exposure_to_heavy_metals_in_the_Tur_River_North_Western_Romania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(15)00252-3 DB - PRIME DP - Unbound Medicine ER -