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Rectal indomethacin for the prevention of post-ERCP pancreatitis: A meta-analysis of randomized controlled trials.
Turk J Gastroenterol. 2015 May; 26(3):236-40.TJ

Abstract

BACKGROUND/AIMS

This meta-analysis was undertaken to evaluate the effect of rectal indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.

MATERIALS AND METHODS

Major databases including Embase, Medline, Science Citation Index Expanded, Pubmed and the Cochrane Central Register of Controlled Trials, were searched to identify all relevant studies from January 1960 to July 2013. Randomized controlled trials (RCTs) comparing prophylactic use of rectal indomethacin versus placebo were included. Risk ratio (RR) with 95% confidence interval (CI) was calculated using fixed- or random-effect models.

RESULTS

Three studies met the inclusion criteria and were included in the final analyses. The overall incidence of post-ERCP pancreatitis (PEP) was significantly decreased by prophylactic rectal indomethacin compared with the placebo (RR=0.51; 95% CI=0.37-0.70). The pooled incidence of moderate to severe pancreatitis was also decreased by rectal indomethacin prophylaxis (RR=0.43; 95% CI=0.23-0.80).

CONCLUSION

Rectal indomethacin can reduce the overall incidence and the severity of PEP.

Authors+Show Affiliations

Sichuan Provincial Pancreatitis Center, Integrated Traditional and Western Medicine, Chengdu, China. xiaqing@medmail.com.cn.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26006198

Citation

Shi, Na, et al. "Rectal Indomethacin for the Prevention of post-ERCP Pancreatitis: a Meta-analysis of Randomized Controlled Trials." The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 26, no. 3, 2015, pp. 236-40.
Shi N, Deng L, Altaf K, et al. Rectal indomethacin for the prevention of post-ERCP pancreatitis: A meta-analysis of randomized controlled trials. Turk J Gastroenterol. 2015;26(3):236-40.
Shi, N., Deng, L., Altaf, K., Huang, W., Xue, P., & Xia, Q. (2015). Rectal indomethacin for the prevention of post-ERCP pancreatitis: A meta-analysis of randomized controlled trials. The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 26(3), 236-40. https://doi.org/10.5152/tjg.2015.6000
Shi N, et al. Rectal Indomethacin for the Prevention of post-ERCP Pancreatitis: a Meta-analysis of Randomized Controlled Trials. Turk J Gastroenterol. 2015;26(3):236-40. PubMed PMID: 26006198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rectal indomethacin for the prevention of post-ERCP pancreatitis: A meta-analysis of randomized controlled trials. AU - Shi,Na, AU - Deng,Lihui, AU - Altaf,Kiran, AU - Huang,Wei, AU - Xue,Ping, AU - Xia,Qing, PY - 2015/5/27/entrez PY - 2015/5/27/pubmed PY - 2016/3/29/medline SP - 236 EP - 40 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 26 IS - 3 N2 - BACKGROUND/AIMS: This meta-analysis was undertaken to evaluate the effect of rectal indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. MATERIALS AND METHODS: Major databases including Embase, Medline, Science Citation Index Expanded, Pubmed and the Cochrane Central Register of Controlled Trials, were searched to identify all relevant studies from January 1960 to July 2013. Randomized controlled trials (RCTs) comparing prophylactic use of rectal indomethacin versus placebo were included. Risk ratio (RR) with 95% confidence interval (CI) was calculated using fixed- or random-effect models. RESULTS: Three studies met the inclusion criteria and were included in the final analyses. The overall incidence of post-ERCP pancreatitis (PEP) was significantly decreased by prophylactic rectal indomethacin compared with the placebo (RR=0.51; 95% CI=0.37-0.70). The pooled incidence of moderate to severe pancreatitis was also decreased by rectal indomethacin prophylaxis (RR=0.43; 95% CI=0.23-0.80). CONCLUSION: Rectal indomethacin can reduce the overall incidence and the severity of PEP. SN - 2148-5607 UR - https://www.unboundmedicine.com/medline/citation/26006198/Rectal_indomethacin_for_the_prevention_of_post_ERCP_pancreatitis:_A_meta_analysis_of_randomized_controlled_trials_ L2 - http://www.turkjgastroenterol.org/eng/makale/4642/285/Full-Text DB - PRIME DP - Unbound Medicine ER -