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Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: A Systematic Review and Meta-Analysis (i-iv).
Nutrients 2015; 7(5):3847-68N

Abstract

Multiple-micronutrient (MMN) fortification of beverages may be an effective option to deliver micronutrients to vulnerable populations. The aim of the present systematic review and meta-analysis is to evaluate the nutritional impacts of MMN fortified beverages in the context of low-middle income countries. A systematic search of published literature yielded 1022 citations, of which 10 randomized controlled trials (nine in school-aged children and one in pregnant women) met inclusion criteria. Results of school-aged children were included in the meta-analysis. Compared to iso-caloric controls, children who received MMN fortified beverages for 8 weeks to 6 months showed significant improvements in hemoglobin (+2.76 g/L, 95% CI [1.19, 4.33], p = 0.004; 8 studies) and serum ferritin (+15.42 pmol/L, [5.73, 25.12], p = 0.007; 8 studies); and reduced risk of anemia (RR 0.58 [0.29, 0.88], p = 0.005; 6 studies), iron deficiency (RR 0.34 [0.21, 0.55], p = 0.002; 7 studies), and iron deficiency anemia (RR 0.17 [0.06, 0.53], p = 0.02; 3 studies). MMN fortified beverage interventions could have major programmatic implications for reducing the burden of anemia and iron deficiency in school-aged children in low-middle income countries. Additional research is needed to investigate effects on other biochemical outcomes and population subgroups.

Authors+Show Affiliations

Section Sanitary Engineering, Department of Water Management, Faculty of Civil Engineering and Geosciences, Delft University of Technology, Delft 2600 GA, The Netherlands. gjaaron@gainhealth.org.Global Alliance for Improved Nutrition (GAIN), Rue de Vermont 37-39, Geneva CH-1202, Switzerland. daphnadror@gmail.com.United States Department of Agriculture (USDA), Western Human Nutrition Research Center (WHNRC), 430 W. Health Sciences Dr., Davis, CA 95616, USA. yang.zhenyuid@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26007336

Citation

Aaron, Grant J., et al. "Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: a Systematic Review and Meta-Analysis (i-iv)." Nutrients, vol. 7, no. 5, 2015, pp. 3847-68.
Aaron GJ, Dror DK, Yang Z. Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: A Systematic Review and Meta-Analysis (i-iv). Nutrients. 2015;7(5):3847-68.
Aaron, G. J., Dror, D. K., & Yang, Z. (2015). Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: A Systematic Review and Meta-Analysis (i-iv). Nutrients, 7(5), pp. 3847-68. doi:10.3390/nu7053847.
Aaron GJ, Dror DK, Yang Z. Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: a Systematic Review and Meta-Analysis (i-iv). Nutrients. 2015 May 21;7(5):3847-68. PubMed PMID: 26007336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: A Systematic Review and Meta-Analysis (i-iv). AU - Aaron,Grant J, AU - Dror,Daphna K, AU - Yang,Zhenyu, Y1 - 2015/05/21/ PY - 2015/02/26/received PY - 2015/04/24/revised PY - 2015/05/05/accepted PY - 2015/5/27/entrez PY - 2015/5/27/pubmed PY - 2016/5/18/medline KW - beverages KW - children KW - fortification KW - low-income KW - multiple-micronutrients SP - 3847 EP - 68 JF - Nutrients JO - Nutrients VL - 7 IS - 5 N2 - Multiple-micronutrient (MMN) fortification of beverages may be an effective option to deliver micronutrients to vulnerable populations. The aim of the present systematic review and meta-analysis is to evaluate the nutritional impacts of MMN fortified beverages in the context of low-middle income countries. A systematic search of published literature yielded 1022 citations, of which 10 randomized controlled trials (nine in school-aged children and one in pregnant women) met inclusion criteria. Results of school-aged children were included in the meta-analysis. Compared to iso-caloric controls, children who received MMN fortified beverages for 8 weeks to 6 months showed significant improvements in hemoglobin (+2.76 g/L, 95% CI [1.19, 4.33], p = 0.004; 8 studies) and serum ferritin (+15.42 pmol/L, [5.73, 25.12], p = 0.007; 8 studies); and reduced risk of anemia (RR 0.58 [0.29, 0.88], p = 0.005; 6 studies), iron deficiency (RR 0.34 [0.21, 0.55], p = 0.002; 7 studies), and iron deficiency anemia (RR 0.17 [0.06, 0.53], p = 0.02; 3 studies). MMN fortified beverage interventions could have major programmatic implications for reducing the burden of anemia and iron deficiency in school-aged children in low-middle income countries. Additional research is needed to investigate effects on other biochemical outcomes and population subgroups. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26007336/Multiple_Micronutrient_Fortified_Non_Dairy_Beverage_Interventions_Reduce_the_Risk_of_Anemia_and_Iron_Deficiency_in_School_Aged_Children_in_Low_Middle_Income_Countries:_A_Systematic_Review_and_Meta_Analysis__i_iv__ L2 - http://www.mdpi.com/resolver?pii=nu7053847 DB - PRIME DP - Unbound Medicine ER -