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Increased association of coronary artery calcification in apparently healthy Korean adults with hypertriglyceridemic waist phenotype: The Kangbuk Samsung Health Study.
Int J Cardiol. 2015 Sep 01; 194:78-82.IJ

Abstract

BACKGROUND

Hypertriglyceridemic waist phenotype is a simple screening parameter to identify people at increased risk for cardiovascular disease. We evaluated whether hypertriglyceridemic waist (HTGW) phenotype increases the risk for coronary artery calcification (CAC) in apparently healthy Korean adults.

METHODS

A total of 32,186 participants (mean age 41.3, 80.2% men) in a health screening program, in whom the coronary artery calcium score (CACS) was measured, were analyzed. Subjects were divided into four groups: 1) normal waist circumference (WC)-normal triglyceride (TG) (NWNT), 2) normal WC-high TG (NWHT), 3) enlarged WC-normal TG (EWNT), and 4) enlarged WC-high TG (EWHT). Enlarged WC was defined as WC ≥ 90 cm for men and ≥ 85 cm for women; high serum TG was defined as TG ≥ 150 mg/dL. The presence of CAC was defined by CACS >0, and CACS was analyzed in a logarithmized form of CACS plus 1 {ln(CACS+1)}.

RESULTS

A total of 14.9% of the participants had CAC. The EWHT group showed the highest mean value for ln(CACS+1) among the four groups. The EWHT group showed the highest odds ratio for CAC, with NWHT group the second, and with EWNT group the third compared with the NWNT group after adjusting for confounding variables (1.579, 1.302, and 1.266 vs. NWNT).

CONCLUSIONS

The EWHT group showed the highest association for CAC, suggesting this HTGW phenotype as a useful marker for the detection of subjects with high cardiometabolic risk in healthy Korean adults.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: hongsiri@hanmail.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26011271

Citation

Moon, Byung Sub, et al. "Increased Association of Coronary Artery Calcification in Apparently Healthy Korean Adults With Hypertriglyceridemic Waist Phenotype: the Kangbuk Samsung Health Study." International Journal of Cardiology, vol. 194, 2015, pp. 78-82.
Moon BS, Park HJ, Lee MK, et al. Increased association of coronary artery calcification in apparently healthy Korean adults with hypertriglyceridemic waist phenotype: The Kangbuk Samsung Health Study. Int J Cardiol. 2015;194:78-82.
Moon, B. S., Park, H. J., Lee, M. K., Jeon, W. S., Park, S. E., Park, C. Y., Lee, W. Y., Oh, K. W., Park, S. W., & Rhee, E. J. (2015). Increased association of coronary artery calcification in apparently healthy Korean adults with hypertriglyceridemic waist phenotype: The Kangbuk Samsung Health Study. International Journal of Cardiology, 194, 78-82. https://doi.org/10.1016/j.ijcard.2015.05.104
Moon BS, et al. Increased Association of Coronary Artery Calcification in Apparently Healthy Korean Adults With Hypertriglyceridemic Waist Phenotype: the Kangbuk Samsung Health Study. Int J Cardiol. 2015 Sep 1;194:78-82. PubMed PMID: 26011271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased association of coronary artery calcification in apparently healthy Korean adults with hypertriglyceridemic waist phenotype: The Kangbuk Samsung Health Study. AU - Moon,Byung Sub, AU - Park,Hye-Jeong, AU - Lee,Min-Kyung, AU - Jeon,Won Seon, AU - Park,Se Eun, AU - Park,Cheol-Young, AU - Lee,Won-Yong, AU - Oh,Ki-Won, AU - Park,Sung-Woo, AU - Rhee,Eun-Jung, Y1 - 2015/05/19/ PY - 2015/01/09/received PY - 2015/05/11/revised PY - 2015/05/17/accepted PY - 2015/5/27/entrez PY - 2015/5/27/pubmed PY - 2016/4/8/medline KW - Abdominal obesity KW - Coronary artery calcification KW - Hypertriglyceridemia SP - 78 EP - 82 JF - International journal of cardiology JO - Int J Cardiol VL - 194 N2 - BACKGROUND: Hypertriglyceridemic waist phenotype is a simple screening parameter to identify people at increased risk for cardiovascular disease. We evaluated whether hypertriglyceridemic waist (HTGW) phenotype increases the risk for coronary artery calcification (CAC) in apparently healthy Korean adults. METHODS: A total of 32,186 participants (mean age 41.3, 80.2% men) in a health screening program, in whom the coronary artery calcium score (CACS) was measured, were analyzed. Subjects were divided into four groups: 1) normal waist circumference (WC)-normal triglyceride (TG) (NWNT), 2) normal WC-high TG (NWHT), 3) enlarged WC-normal TG (EWNT), and 4) enlarged WC-high TG (EWHT). Enlarged WC was defined as WC ≥ 90 cm for men and ≥ 85 cm for women; high serum TG was defined as TG ≥ 150 mg/dL. The presence of CAC was defined by CACS >0, and CACS was analyzed in a logarithmized form of CACS plus 1 {ln(CACS+1)}. RESULTS: A total of 14.9% of the participants had CAC. The EWHT group showed the highest mean value for ln(CACS+1) among the four groups. The EWHT group showed the highest odds ratio for CAC, with NWHT group the second, and with EWNT group the third compared with the NWNT group after adjusting for confounding variables (1.579, 1.302, and 1.266 vs. NWNT). CONCLUSIONS: The EWHT group showed the highest association for CAC, suggesting this HTGW phenotype as a useful marker for the detection of subjects with high cardiometabolic risk in healthy Korean adults. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/26011271/Increased_association_of_coronary_artery_calcification_in_apparently_healthy_Korean_adults_with_hypertriglyceridemic_waist_phenotype:_The_Kangbuk_Samsung_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(15)01165-1 DB - PRIME DP - Unbound Medicine ER -