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Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial.
Age (Dordr). 2015 Jun; 37(3):9794.A

Abstract

Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake can improve vascular function in healthy young and elderly at-risk individuals. However, the mechanisms underlying CF bioactivity remain largely unknown. We investigated the effects of CF intake on cardiovascular function in healthy young and elderly individuals without history, signs, or symptoms of cardiovascular disease by applying particular focus on functional endpoints relevant to cardiovascular aging. In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 22 young (<35 years) and 20 elderly (50-80 year) healthy, male non-smokers consumed either a CF-containing drink (450 mg CF) or nutrient-matched, CF-free control drink bi-daily for 14 days. The primary endpoint was endothelial function as measured by flow-mediated vasodilation (FMD). Secondary endpoints included cardiac output, vascular stiffness, conductance of conduit and resistance arteries, and perfusion in the microcirculation. Following 2 weeks of CF intake, FMD improved in young (6.1 ± 0.7 vs. 7.6 ± 0.7 %, p < 0.001) and elderly (4.9 ± 0.6 vs. 6.3 ± 0.9 %, p < 0.001). Secondary outcomes demonstrated in both groups that CF intake decreased pulse wave velocity and lowered total peripheral resistance, and increased arteriolar and microvascular vasodilator capacity, red cell deformability, and diastolic blood pressure, while cardiac output remained affected. In the elderly, baseline systolic blood pressure was elevated, driven by an arterial-stiffness-related augmentation. CF intake decreased aortic augmentation index (-9 %) and thus systolic blood pressure (-7 mmHg; Clinicaltrials.gov: NCT01639781). CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health.

Authors+Show Affiliations

Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Medical Faculty, Moorenstr. 5, 40225, Duesseldorf, Germany, christian.heiss@med.uni-duesseldorf.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26013912

Citation

Heiss, Christian, et al. "Impact of Cocoa Flavanol Intake On Age-dependent Vascular Stiffness in Healthy Men: a Randomized, Controlled, Double-masked Trial." Age (Dordrecht, Netherlands), vol. 37, no. 3, 2015, p. 9794.
Heiss C, Sansone R, Karimi H, et al. Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordr). 2015;37(3):9794.
Heiss, C., Sansone, R., Karimi, H., Krabbe, M., Schuler, D., Rodriguez-Mateos, A., Kraemer, T., Cortese-Krott, M. M., Kuhnle, G. G., Spencer, J. P., Schroeter, H., Merx, M. W., & Kelm, M. (2015). Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Age (Dordrecht, Netherlands), 37(3), 9794. https://doi.org/10.1007/s11357-015-9794-9
Heiss C, et al. Impact of Cocoa Flavanol Intake On Age-dependent Vascular Stiffness in Healthy Men: a Randomized, Controlled, Double-masked Trial. Age (Dordr). 2015;37(3):9794. PubMed PMID: 26013912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. AU - Heiss,Christian, AU - Sansone,Roberto, AU - Karimi,Hakima, AU - Krabbe,Moritz, AU - Schuler,Dominik, AU - Rodriguez-Mateos,Ana, AU - Kraemer,Thomas, AU - Cortese-Krott,Miriam Margherita, AU - Kuhnle,Gunter G C, AU - Spencer,Jeremy P E, AU - Schroeter,Hagen, AU - Merx,Marc W, AU - Kelm,Malte, AU - ,, Y1 - 2015/05/27/ PY - 2015/02/08/received PY - 2015/05/15/accepted PY - 2015/5/28/entrez PY - 2015/5/28/pubmed PY - 2016/1/14/medline SP - 9794 EP - 9794 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 37 IS - 3 N2 - Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake can improve vascular function in healthy young and elderly at-risk individuals. However, the mechanisms underlying CF bioactivity remain largely unknown. We investigated the effects of CF intake on cardiovascular function in healthy young and elderly individuals without history, signs, or symptoms of cardiovascular disease by applying particular focus on functional endpoints relevant to cardiovascular aging. In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 22 young (<35 years) and 20 elderly (50-80 year) healthy, male non-smokers consumed either a CF-containing drink (450 mg CF) or nutrient-matched, CF-free control drink bi-daily for 14 days. The primary endpoint was endothelial function as measured by flow-mediated vasodilation (FMD). Secondary endpoints included cardiac output, vascular stiffness, conductance of conduit and resistance arteries, and perfusion in the microcirculation. Following 2 weeks of CF intake, FMD improved in young (6.1 ± 0.7 vs. 7.6 ± 0.7 %, p < 0.001) and elderly (4.9 ± 0.6 vs. 6.3 ± 0.9 %, p < 0.001). Secondary outcomes demonstrated in both groups that CF intake decreased pulse wave velocity and lowered total peripheral resistance, and increased arteriolar and microvascular vasodilator capacity, red cell deformability, and diastolic blood pressure, while cardiac output remained affected. In the elderly, baseline systolic blood pressure was elevated, driven by an arterial-stiffness-related augmentation. CF intake decreased aortic augmentation index (-9 %) and thus systolic blood pressure (-7 mmHg; Clinicaltrials.gov: NCT01639781). CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/26013912/Impact_of_cocoa_flavanol_intake_on_age_dependent_vascular_stiffness_in_healthy_men:_a_randomized_controlled_double_masked_trial_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26013912/ DB - PRIME DP - Unbound Medicine ER -