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Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder.
Nutrition. 2015 Jul-Aug; 31(7-8):935-40.N

Abstract

OBJECTIVE

Little attention has been paid to the possible protective role of ω-3 polyunsaturated fatty acids (PUFAs) on the visual acuity of school-age children with lower IQs or attention-deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the effect of dietary ω-3 PUFAs on the visual acuity and red blood cell (RBC) fatty acid compositions of these children.

METHODS

We randomly assigned 179 children with lower IQs or ADHD to receive ordinary eggs (control group, n = 90) or eggs rich in C18:3 ω-3, eicosapentaenoic acid (EPA, 20:5 ω-3) and docosahexaenoic acid (DHA, 22:6 ω-3) for 3 mo (study group, n = 89). Before and after the intervention, distance visual acuity was tested using an E chart and the RBC fatty acid composition was determined using capillary gas chromatography.

RESULTS

Three months later, 171 children completed the follow-up with the exception of 8 children who were unavailable during follow-up. Both groups of children showed a significant improvement in visual acuity (P < 0.05), however, visual acuity in the study group was significantly better than that of the control group (P = 0.013). The C18:3 ω-3 (P = 0.009), DHA (P = 0.009) and ∑ω-3 (P = 0.022) levels of the intervention group were significantly higher than those of the control group, while the C20:4 ω-6 (P = 0.003), C22:4 ω-6 (P = 0.000), ∑ω-6 (P = 0.001), ∑ω-6/∑ω-3 (P = 0.000) and arachidonic acid/DHA (P = 0.000) of the study group were significantly lower than those of the control group. No significant differences in the levels of C18:2 ω-6 (P = 0.723), C20:2 ω-6 (P = 0.249), C20:3 ω-6 (P = 0.258), C20:5 ω-3 (P = 0.051), or C22:5 (P = 0.200) were found between the two groups.

CONCLUSIONS

Dietary supplementation with ω-3 PUFAs improves both visual acuity and the RBC fatty acid profile in school-age children with lower IQs or ADHD.

Authors+Show Affiliations

Department of Child Health Care, Children's Hospital, Fudan University, Shanghai, China.Department of Child Health Care, Children's Hospital, Fudan University, Shanghai, China.Centre for Disease Control, Yuyao, China.Department of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, China.Department of Child Health Care, Children's Hospital, Fudan University, Shanghai, China. Electronic address: ympeng@fudan.edu.cn.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26015389

Citation

Wu, Qiaoling, et al. "Protective Effects of Dietary Supplementation With Natural Ω-3 Polyunsaturated Fatty Acids On the Visual Acuity of School-age Children With Lower IQ or Attention-deficit Hyperactivity Disorder." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 7-8, 2015, pp. 935-40.
Wu Q, Zhou T, Ma L, et al. Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. Nutrition. 2015;31(7-8):935-40.
Wu, Q., Zhou, T., Ma, L., Yuan, D., & Peng, Y. (2015). Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. Nutrition (Burbank, Los Angeles County, Calif.), 31(7-8), 935-40. https://doi.org/10.1016/j.nut.2014.12.026
Wu Q, et al. Protective Effects of Dietary Supplementation With Natural Ω-3 Polyunsaturated Fatty Acids On the Visual Acuity of School-age Children With Lower IQ or Attention-deficit Hyperactivity Disorder. Nutrition. 2015 Jul-Aug;31(7-8):935-40. PubMed PMID: 26015389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. AU - Wu,Qiaoling, AU - Zhou,Tingting, AU - Ma,Liping, AU - Yuan,Dongjuan, AU - Peng,Yongmei, Y1 - 2015/01/13/ PY - 2014/03/03/received PY - 2014/10/08/revised PY - 2014/12/17/accepted PY - 2015/5/28/entrez PY - 2015/5/28/pubmed PY - 2016/5/3/medline KW - Attention-deficit hyperactivity disorder KW - Dietary supplementation KW - Lower IQ KW - School-age children KW - Visual acuity KW - ω-3 polyunsaturated fatty acids SP - 935 EP - 40 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 7-8 N2 - OBJECTIVE: Little attention has been paid to the possible protective role of ω-3 polyunsaturated fatty acids (PUFAs) on the visual acuity of school-age children with lower IQs or attention-deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the effect of dietary ω-3 PUFAs on the visual acuity and red blood cell (RBC) fatty acid compositions of these children. METHODS: We randomly assigned 179 children with lower IQs or ADHD to receive ordinary eggs (control group, n = 90) or eggs rich in C18:3 ω-3, eicosapentaenoic acid (EPA, 20:5 ω-3) and docosahexaenoic acid (DHA, 22:6 ω-3) for 3 mo (study group, n = 89). Before and after the intervention, distance visual acuity was tested using an E chart and the RBC fatty acid composition was determined using capillary gas chromatography. RESULTS: Three months later, 171 children completed the follow-up with the exception of 8 children who were unavailable during follow-up. Both groups of children showed a significant improvement in visual acuity (P < 0.05), however, visual acuity in the study group was significantly better than that of the control group (P = 0.013). The C18:3 ω-3 (P = 0.009), DHA (P = 0.009) and ∑ω-3 (P = 0.022) levels of the intervention group were significantly higher than those of the control group, while the C20:4 ω-6 (P = 0.003), C22:4 ω-6 (P = 0.000), ∑ω-6 (P = 0.001), ∑ω-6/∑ω-3 (P = 0.000) and arachidonic acid/DHA (P = 0.000) of the study group were significantly lower than those of the control group. No significant differences in the levels of C18:2 ω-6 (P = 0.723), C20:2 ω-6 (P = 0.249), C20:3 ω-6 (P = 0.258), C20:5 ω-3 (P = 0.051), or C22:5 (P = 0.200) were found between the two groups. CONCLUSIONS: Dietary supplementation with ω-3 PUFAs improves both visual acuity and the RBC fatty acid profile in school-age children with lower IQs or ADHD. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/26015389/Protective_effects_of_dietary_supplementation_with_natural_ω_3_polyunsaturated_fatty_acids_on_the_visual_acuity_of_school_age_children_with_lower_IQ_or_attention_deficit_hyperactivity_disorder_ DB - PRIME DP - Unbound Medicine ER -