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Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds.
Molecules. 2015 May 26; 20(6):9560-74.M

Abstract

This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g-1 dw plant material), in the N. damascena extract. Regarding the flavonol profile, kaempferol was identified before the hydrolysis, only in the N. sativa extract (6.06 ± 0.02 μg∙g-1 dw plant material) and quercetin only in N. damascena seeds (14.35 ± 0.02 μg∙g-1 dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg∙kg-1) resulted in a significant increase in urine volume, although less than found with the reference drug; in addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na+, K+ and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na+/K+ ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na+ excretion.

Authors+Show Affiliations

Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiș Western University of Arad, 86, Rebreanu Street, Arad 310414, Romania. claudiatoma@uvvg.com.Faculty of Medicine, Pharmacy and Dental Medicine, Vasile Goldiș Western University of Arad, 86, Rebreanu Street, Arad 310414, Romania. neliolah@yahoo.com. SC PlantExtrakt SRL, Rădaia 407059, Cluj, Romania. neliolah@yahoo.com.Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca 400010, Romania. laurian.vlase@umfcluj.ro.Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca 400010, Romania. cmogosan@umfcluj.ro.Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca 400010, Romania. mocan.andrei@umfcluj.ro.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26016547

Citation

Toma, Claudia-Crina, et al. "Comparative Studies On Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella Sativa L. (Black Cumin) and Nigella Damascena L. (Lady-in-a-Mist) Seeds." Molecules (Basel, Switzerland), vol. 20, no. 6, 2015, pp. 9560-74.
Toma CC, Olah NK, Vlase L, et al. Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules. 2015;20(6):9560-74.
Toma, C. C., Olah, N. K., Vlase, L., Mogoșan, C., & Mocan, A. (2015). Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. Molecules (Basel, Switzerland), 20(6), 9560-74. https://doi.org/10.3390/molecules20069560
Toma CC, et al. Comparative Studies On Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella Sativa L. (Black Cumin) and Nigella Damascena L. (Lady-in-a-Mist) Seeds. Molecules. 2015 May 26;20(6):9560-74. PubMed PMID: 26016547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds. AU - Toma,Claudia-Crina, AU - Olah,Neli-Kinga, AU - Vlase,Laurian, AU - Mogoșan,Cristina, AU - Mocan,Andrei, Y1 - 2015/05/26/ PY - 2015/04/20/received PY - 2015/05/17/revised PY - 2015/05/18/accepted PY - 2015/5/29/entrez PY - 2015/5/29/pubmed PY - 2016/2/20/medline KW - N. damascena L. KW - Nigella sativa L. KW - antioxidants KW - diuretic KW - polyphenols KW - seeds SP - 9560 EP - 74 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 20 IS - 6 N2 - This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g-1 dw plant material), in the N. damascena extract. Regarding the flavonol profile, kaempferol was identified before the hydrolysis, only in the N. sativa extract (6.06 ± 0.02 μg∙g-1 dw plant material) and quercetin only in N. damascena seeds (14.35 ± 0.02 μg∙g-1 dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg∙kg-1) resulted in a significant increase in urine volume, although less than found with the reference drug; in addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na+, K+ and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na+/K+ ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na+ excretion. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/26016547/Comparative_Studies_on_Polyphenolic_Composition_Antioxidant_and_Diuretic_Effects_of_Nigella_sativa_L___Black_Cumin__and_Nigella_damascena_L___Lady_in_a_Mist__Seeds_ L2 - https://www.mdpi.com/resolver?pii=molecules20069560 DB - PRIME DP - Unbound Medicine ER -