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Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults.
Am J Clin Nutr. 2015 Jul; 102(1):172-81.AJ

Abstract

BACKGROUND

Although growing evidence from trials and population-based studies has supported a protective role for flavonoids in relation to risk of certain chronic diseases, the underlying mechanisms remain unclear. Several previous studies focused on individual inflammatory biomarkers, but because of the limited specificity of any individual marker, an assessment of a combination of biomarkers may be more informative.

OBJECTIVE

We used an inflammation score (IS) that integrated 12 individual inflammatory biomarkers for the examination of associations with intakes of different flavonoid classes.

DESIGN

The study was a cross-sectional analysis of 2375 Framingham Heart Study Offspring Cohort participants. Intakes of total flavonoids and their classes (anthocyanins, flavonols, flavanones, flavan-3-ols, polymers, and flavones) were calculated from validated food-frequency questionnaires. Individual inflammatory biomarkers were ranked, standardized, and summed to derive an overall IS and subgroup scores of functionally related biomarkers.

RESULTS

In multivariate analyses, an inverse association between higher anthocyanin and flavonol intakes and IS was observed with a mean ± SE difference between quintile categories 5 and 1 of -1.48 ± 0.32 (P-trend ≤ 0.001) and -0.72 ± 0.33 (P-trend = 0.01), respectively. Results remained significant after additional adjustment for physical activity and vitamin C and fruit and vegetable intakes. Higher anthocyanin intake was inversely associated with all biomarker subgroups, whereas higher flavonol intake was associated only with lower cytokine and oxidative stress biomarker concentrations. In food-based analyses, higher intakes of apples and pears, red wine, and strawberries were associated with a lower IS with differences between quintiles 5 and 1 of -1.02 ± 0.43 (P = 0.006), -1.73 ± 0.39 (P < 0.001), and -0.44 ± 0.88 (P = 0.02), respectively. Although intakes of other classes were not associated with a reduction in overall IS, higher intakes of flavan-3-ols and their polymers were associated with a significant reduction in oxidative stress biomarkers.

CONCLUSION

These findings provide evidence to suggest that an anti-inflammatory effect may be a key component underlying the reduction in risk of certain chronic diseases associated with higher intakes of anthocyanins and flavonols. The Framingham Offspring Study was registered at clinicaltrials.gov as NCT00005121 (Framingham Heart Study).

Authors+Show Affiliations

Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom;Jean Mayer USDA Human Nutrition Research Center on Aging and.The Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA;Jean Mayer USDA Human Nutrition Research Center on Aging and The Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA; Tufts University School of Medicine and Frances Stern Nutrition Center, Tufts Medical Center, Boston, MA; and.Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA.Jean Mayer USDA Human Nutrition Research Center on Aging and The Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA; paul.jacques@tufts.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26016863

Citation

Cassidy, Aedin, et al. "Higher Dietary Anthocyanin and Flavonol Intakes Are Associated With Anti-inflammatory Effects in a Population of US Adults." The American Journal of Clinical Nutrition, vol. 102, no. 1, 2015, pp. 172-81.
Cassidy A, Rogers G, Peterson JJ, et al. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Am J Clin Nutr. 2015;102(1):172-81.
Cassidy, A., Rogers, G., Peterson, J. J., Dwyer, J. T., Lin, H., & Jacques, P. F. (2015). Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. The American Journal of Clinical Nutrition, 102(1), 172-81. https://doi.org/10.3945/ajcn.115.108555
Cassidy A, et al. Higher Dietary Anthocyanin and Flavonol Intakes Are Associated With Anti-inflammatory Effects in a Population of US Adults. Am J Clin Nutr. 2015;102(1):172-81. PubMed PMID: 26016863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. AU - Cassidy,Aedin, AU - Rogers,Gail, AU - Peterson,Julia J, AU - Dwyer,Johanna T, AU - Lin,Honghuang, AU - Jacques,Paul F, Y1 - 2015/05/27/ PY - 2015/02/03/received PY - 2015/04/28/accepted PY - 2015/5/29/entrez PY - 2015/5/29/pubmed PY - 2015/9/12/medline KW - anthocyanins KW - dietary intake KW - flavonoids KW - flavonols KW - inflammation SP - 172 EP - 81 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 102 IS - 1 N2 - BACKGROUND: Although growing evidence from trials and population-based studies has supported a protective role for flavonoids in relation to risk of certain chronic diseases, the underlying mechanisms remain unclear. Several previous studies focused on individual inflammatory biomarkers, but because of the limited specificity of any individual marker, an assessment of a combination of biomarkers may be more informative. OBJECTIVE: We used an inflammation score (IS) that integrated 12 individual inflammatory biomarkers for the examination of associations with intakes of different flavonoid classes. DESIGN: The study was a cross-sectional analysis of 2375 Framingham Heart Study Offspring Cohort participants. Intakes of total flavonoids and their classes (anthocyanins, flavonols, flavanones, flavan-3-ols, polymers, and flavones) were calculated from validated food-frequency questionnaires. Individual inflammatory biomarkers were ranked, standardized, and summed to derive an overall IS and subgroup scores of functionally related biomarkers. RESULTS: In multivariate analyses, an inverse association between higher anthocyanin and flavonol intakes and IS was observed with a mean ± SE difference between quintile categories 5 and 1 of -1.48 ± 0.32 (P-trend ≤ 0.001) and -0.72 ± 0.33 (P-trend = 0.01), respectively. Results remained significant after additional adjustment for physical activity and vitamin C and fruit and vegetable intakes. Higher anthocyanin intake was inversely associated with all biomarker subgroups, whereas higher flavonol intake was associated only with lower cytokine and oxidative stress biomarker concentrations. In food-based analyses, higher intakes of apples and pears, red wine, and strawberries were associated with a lower IS with differences between quintiles 5 and 1 of -1.02 ± 0.43 (P = 0.006), -1.73 ± 0.39 (P < 0.001), and -0.44 ± 0.88 (P = 0.02), respectively. Although intakes of other classes were not associated with a reduction in overall IS, higher intakes of flavan-3-ols and their polymers were associated with a significant reduction in oxidative stress biomarkers. CONCLUSION: These findings provide evidence to suggest that an anti-inflammatory effect may be a key component underlying the reduction in risk of certain chronic diseases associated with higher intakes of anthocyanins and flavonols. The Framingham Offspring Study was registered at clinicaltrials.gov as NCT00005121 (Framingham Heart Study). SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26016863/Higher_dietary_anthocyanin_and_flavonol_intakes_are_associated_with_anti_inflammatory_effects_in_a_population_of_US_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.108555 DB - PRIME DP - Unbound Medicine ER -