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Emerging treatments for the primary headache disorders.
Neurol Sci. 2015 May; 36 Suppl 1:109-13.NS

Abstract

Migraine and cluster headache are common, episodic, often chronic and disabling disorders of the brain. Although there are many standard treatment techniques, none are ideal. This article reviews various novel pharmacologic and device-related treatments for migraine and cluster headache. Emphasis is given to recent advances in the development of monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) and its receptor, including promising results from phase 2 trials studying the safety and efficacy of LY2951742, ALD403 and TEV-48125, three anti-CGRP mAbs. Other new pharmacologic treatments discussed include the 5-HT1F receptor agonist lasmiditan and glial cell modulator ibudilast. Also reviewed is neuromodulation for migraine and cluster headache, including promising recent results of randomized controlled trials studying sphenopalatine ganglion stimulation, trigeminal nerve stimulation, transcutaneous vagus nerve stimulation, and transcranial magnetic stimulation. Finally, we discuss patch, inhaled, and intranasal methods of triptan and dihydroergotamine delivery.

Authors+Show Affiliations

Department of Neurology, Ronald Reagan-UCLA Medical Center, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Suite 1240, Los Angeles, CA, 90024, USA, nschuster@gmail.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26017524

Citation

Schuster, Nathaniel M., et al. "Emerging Treatments for the Primary Headache Disorders." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 36 Suppl 1, 2015, pp. 109-13.
Schuster NM, Vollbracht S, Rapoport AM. Emerging treatments for the primary headache disorders. Neurol Sci. 2015;36 Suppl 1:109-13.
Schuster, N. M., Vollbracht, S., & Rapoport, A. M. (2015). Emerging treatments for the primary headache disorders. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36 Suppl 1, 109-13. https://doi.org/10.1007/s10072-015-2133-1
Schuster NM, Vollbracht S, Rapoport AM. Emerging Treatments for the Primary Headache Disorders. Neurol Sci. 2015;36 Suppl 1:109-13. PubMed PMID: 26017524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging treatments for the primary headache disorders. AU - Schuster,Nathaniel M, AU - Vollbracht,Sarah, AU - Rapoport,Alan M, PY - 2015/5/29/entrez PY - 2015/5/29/pubmed PY - 2016/2/18/medline SP - 109 EP - 13 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 36 Suppl 1 N2 - Migraine and cluster headache are common, episodic, often chronic and disabling disorders of the brain. Although there are many standard treatment techniques, none are ideal. This article reviews various novel pharmacologic and device-related treatments for migraine and cluster headache. Emphasis is given to recent advances in the development of monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) and its receptor, including promising results from phase 2 trials studying the safety and efficacy of LY2951742, ALD403 and TEV-48125, three anti-CGRP mAbs. Other new pharmacologic treatments discussed include the 5-HT1F receptor agonist lasmiditan and glial cell modulator ibudilast. Also reviewed is neuromodulation for migraine and cluster headache, including promising recent results of randomized controlled trials studying sphenopalatine ganglion stimulation, trigeminal nerve stimulation, transcutaneous vagus nerve stimulation, and transcranial magnetic stimulation. Finally, we discuss patch, inhaled, and intranasal methods of triptan and dihydroergotamine delivery. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/26017524/Emerging_treatments_for_the_primary_headache_disorders_ L2 - https://link.springer.com/10.1007/s10072-015-2133-1 DB - PRIME DP - Unbound Medicine ER -