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1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice.
Curr Alzheimer Res 2015; 12(5):481-92CA

Abstract

The involvement of radiofrequency electromagnetic fields (RF-EMF) in the neurodegenerative disease, especially Alzheimer's disease (AD), has received wide consideration, however, outcomes from several researches have not shown consistency. In this study, we determined whether RF-EMF influenced AD pathology in vivo using Tg-5xFAD mice as a model of AD-like amyloid β (Aβ) pathology. The transgenic (Tg)-5xFAD and wild type (WT) mice were chronically exposed to RF-EMF for 8 months (1950 MHz, SAR 5W/kg, 2 hrs/day, 5 days/week). Notably, chronic RFEMF exposure significantly reduced not only Aβ plaques, APP, and APP carboxyl-terminal fragments (CTFs) in whole brain including hippocampus and entorhinal cortex but also the ratio of Aβ42 and Aβ40 peptide in the hippocampus of Tg-5xFAD mice. We also found that parenchymal expression of β-amyloid precursor protein cleaving enzyme 1(BACE1) and neuroinflammation were inhibited by RF-EMF exposure in Tg-5xFAD. In addition, RF-EMF was shown to rescue memory impairment in Tg-5xFAD. Moreover, gene profiling from microarray data using hippocampus of WT and Tg- 5xFAD following RF-EMF exposure revealed that 5 genes (Tshz2, Gm12695, St3gal1, Isx and Tll1), which are involved in Aβ, are significantly altered inTg-5xFAD mice, exhibiting different responses to RF-EMF in WT or Tg-5xFAD mice; RF-EMF exposure in WT mice showed similar patterns to control Tg-5xFAD mice, however, RF-EMF exposure in Tg- 5xFAD mice showed opposite expression patterns. These findings indicate that chronic RF-EMF exposure directly affects Aβ pathology in AD but not in normal brain. Therefore, RF-EMF has preventive effects against AD-like pathology in advanced AD mice with a high expression of Aβ, which suggests that RF-EMF can have a beneficial influence on AD.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDivision of Radiation Effects, Korea Institute of Radiological & Medical Sciences, Seoul, 139-706, Korea. hjlee@kirams.re.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26017559

Citation

Jeong, Ye Ji, et al. "1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice." Current Alzheimer Research, vol. 12, no. 5, 2015, pp. 481-92.
Jeong YJ, Kang GY, Kwon JH, et al. 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice. Curr Alzheimer Res. 2015;12(5):481-92.
Jeong, Y. J., Kang, G. Y., Kwon, J. H., Choi, H. D., Pack, J. K., Kim, N., ... Lee, H. J. (2015). 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice. Current Alzheimer Research, 12(5), pp. 481-92.
Jeong YJ, et al. 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice. Curr Alzheimer Res. 2015;12(5):481-92. PubMed PMID: 26017559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice. AU - Jeong,Ye Ji, AU - Kang,Ga-Young, AU - Kwon,Jong Hwa, AU - Choi,Hyung-Do, AU - Pack,Jeong-Ki, AU - Kim,Nam, AU - Lee,Yun-Sil, AU - Lee,Hae-June, PY - 2014/12/17/received PY - 2015/03/16/revised PY - 2015/03/21/accepted PY - 2015/5/29/entrez PY - 2015/5/29/pubmed PY - 2016/2/16/medline SP - 481 EP - 92 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 12 IS - 5 N2 - The involvement of radiofrequency electromagnetic fields (RF-EMF) in the neurodegenerative disease, especially Alzheimer's disease (AD), has received wide consideration, however, outcomes from several researches have not shown consistency. In this study, we determined whether RF-EMF influenced AD pathology in vivo using Tg-5xFAD mice as a model of AD-like amyloid β (Aβ) pathology. The transgenic (Tg)-5xFAD and wild type (WT) mice were chronically exposed to RF-EMF for 8 months (1950 MHz, SAR 5W/kg, 2 hrs/day, 5 days/week). Notably, chronic RFEMF exposure significantly reduced not only Aβ plaques, APP, and APP carboxyl-terminal fragments (CTFs) in whole brain including hippocampus and entorhinal cortex but also the ratio of Aβ42 and Aβ40 peptide in the hippocampus of Tg-5xFAD mice. We also found that parenchymal expression of β-amyloid precursor protein cleaving enzyme 1(BACE1) and neuroinflammation were inhibited by RF-EMF exposure in Tg-5xFAD. In addition, RF-EMF was shown to rescue memory impairment in Tg-5xFAD. Moreover, gene profiling from microarray data using hippocampus of WT and Tg- 5xFAD following RF-EMF exposure revealed that 5 genes (Tshz2, Gm12695, St3gal1, Isx and Tll1), which are involved in Aβ, are significantly altered inTg-5xFAD mice, exhibiting different responses to RF-EMF in WT or Tg-5xFAD mice; RF-EMF exposure in WT mice showed similar patterns to control Tg-5xFAD mice, however, RF-EMF exposure in Tg- 5xFAD mice showed opposite expression patterns. These findings indicate that chronic RF-EMF exposure directly affects Aβ pathology in AD but not in normal brain. Therefore, RF-EMF has preventive effects against AD-like pathology in advanced AD mice with a high expression of Aβ, which suggests that RF-EMF can have a beneficial influence on AD. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/26017559/1950_MHz_Electromagnetic_Fields_Ameliorate_Aβ_Pathology_in_Alzheimer's_Disease_Mice_ L2 - http://www.eurekaselect.com/131679/article DB - PRIME DP - Unbound Medicine ER -