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The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses.
Mol Nutr Food Res. 2015 Sep; 59(9):1745-57.MN

Abstract

SCOPE

Consumption of a low-fat spread enriched with plant sterols (PS) and different low doses (<2 g/day) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil reduces serum triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-Chol) and thus beneficially affects two blood lipid risk factors. Yet, their combined effects on TG and Chol in various lipoprotein subclasses have been investigated to a limited extent.

METHODS AND RESULTS

In a randomized, double-blind, placebo-controlled, parallel study, we determined TG and Chol in 13 LP subclasses in fasting serum of 282 hypercholesterolemic subjects, who consumed either a placebo spread or one of the four spreads containing PS (2.5 g/day) and EPA+DHA (0.0, 0.9, 1.3, and 1.8 g/day) for 4 weeks. After PS treatment, total LDL-Chol was reduced, which was not further changed by EPA+DHA. No shift in the LDL-Chol particle distribution was observed. The addition of EPA+DHA to PS dose-dependently reduced VLDL-Chol and VLDL-TG mainly in larger particles. Furthermore, the two highest doses of EPA+DHA increased Chol and TG in the larger HDL particles, while these concentrations were decreased in the smallest HDL particles.

CONCLUSION

The consumption of a low-fat spread enriched with both PS and EPA+DHA induced shifts in the lipoprotein distribution that may provide additional cardiovascular benefits over PS consumption alone.

Authors+Show Affiliations

Unilever R&D, Vlaardingen, The Netherlands. Netherlands Metabolomics Centre, Leiden, The Netherlands.Netherlands Metabolomics Centre, Leiden, The Netherlands. Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.Microbiology and Systems Biology, TNO, Zeist, The Netherlands.Microbiology and Systems Biology, TNO, Zeist, The Netherlands.Netherlands Metabolomics Centre, Leiden, The Netherlands. Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands.Unilever R&D, Vlaardingen, The Netherlands. Netherlands Metabolomics Centre, Leiden, The Netherlands.Unilever R&D, Vlaardingen, The Netherlands.Unilever R&D, Vlaardingen, The Netherlands.Unilever R&D, Vlaardingen, The Netherlands.Unilever R&D, Vlaardingen, The Netherlands. Netherlands Metabolomics Centre, Leiden, The Netherlands. Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26019023

Citation

Jacobs, Doris M., et al. "The Effect of Plant Sterols and Different Low Doses of Omega-3 Fatty Acids From Fish Oil On Lipoprotein Subclasses." Molecular Nutrition & Food Research, vol. 59, no. 9, 2015, pp. 1745-57.
Jacobs DM, Mihaleva VV, van Schalkwijk DB, et al. The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses. Mol Nutr Food Res. 2015;59(9):1745-57.
Jacobs, D. M., Mihaleva, V. V., van Schalkwijk, D. B., de Graaf, A. A., Vervoort, J., van Dorsten, F. A., Ras, R. T., Demonty, I., Trautwein, E. A., & van Duynhoven, J. (2015). The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses. Molecular Nutrition & Food Research, 59(9), 1745-57. https://doi.org/10.1002/mnfr.201500152
Jacobs DM, et al. The Effect of Plant Sterols and Different Low Doses of Omega-3 Fatty Acids From Fish Oil On Lipoprotein Subclasses. Mol Nutr Food Res. 2015;59(9):1745-57. PubMed PMID: 26019023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses. AU - Jacobs,Doris M, AU - Mihaleva,Velitchka V, AU - van Schalkwijk,Daniël B, AU - de Graaf,Albert A, AU - Vervoort,Jacques, AU - van Dorsten,Ferdinand A, AU - Ras,Rouyanne T, AU - Demonty,Isabelle, AU - Trautwein,Elke A, AU - van Duynhoven,John, Y1 - 2015/06/22/ PY - 2015/02/26/received PY - 2015/04/28/revised PY - 2015/05/06/accepted PY - 2015/5/29/entrez PY - 2015/5/29/pubmed PY - 2016/7/29/medline KW - Lipoprotein KW - NMR KW - Particle Profiler KW - Plant sterols KW - n-3 fatty acids SP - 1745 EP - 57 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 59 IS - 9 N2 - SCOPE: Consumption of a low-fat spread enriched with plant sterols (PS) and different low doses (<2 g/day) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil reduces serum triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-Chol) and thus beneficially affects two blood lipid risk factors. Yet, their combined effects on TG and Chol in various lipoprotein subclasses have been investigated to a limited extent. METHODS AND RESULTS: In a randomized, double-blind, placebo-controlled, parallel study, we determined TG and Chol in 13 LP subclasses in fasting serum of 282 hypercholesterolemic subjects, who consumed either a placebo spread or one of the four spreads containing PS (2.5 g/day) and EPA+DHA (0.0, 0.9, 1.3, and 1.8 g/day) for 4 weeks. After PS treatment, total LDL-Chol was reduced, which was not further changed by EPA+DHA. No shift in the LDL-Chol particle distribution was observed. The addition of EPA+DHA to PS dose-dependently reduced VLDL-Chol and VLDL-TG mainly in larger particles. Furthermore, the two highest doses of EPA+DHA increased Chol and TG in the larger HDL particles, while these concentrations were decreased in the smallest HDL particles. CONCLUSION: The consumption of a low-fat spread enriched with both PS and EPA+DHA induced shifts in the lipoprotein distribution that may provide additional cardiovascular benefits over PS consumption alone. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/26019023/The_effect_of_plant_sterols_and_different_low_doses_of_omega_3_fatty_acids_from_fish_oil_on_lipoprotein_subclasses_ L2 - https://doi.org/10.1002/mnfr.201500152 DB - PRIME DP - Unbound Medicine ER -