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The Effect of Proton Pump Inhibitors on Barrett's Esophagus.
Gastroenterol Clin North Am. 2015 Jun; 44(2):415-24.GC

Abstract

Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA. Electronic address: Kerry.Dunbar@utsouthwestern.edu.Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA.Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26021202

Citation

Dunbar, Kerry B., et al. "The Effect of Proton Pump Inhibitors On Barrett's Esophagus." Gastroenterology Clinics of North America, vol. 44, no. 2, 2015, pp. 415-24.
Dunbar KB, Souza RF, Spechler SJ. The Effect of Proton Pump Inhibitors on Barrett's Esophagus. Gastroenterol Clin North Am. 2015;44(2):415-24.
Dunbar, K. B., Souza, R. F., & Spechler, S. J. (2015). The Effect of Proton Pump Inhibitors on Barrett's Esophagus. Gastroenterology Clinics of North America, 44(2), 415-24. https://doi.org/10.1016/j.gtc.2015.02.010
Dunbar KB, Souza RF, Spechler SJ. The Effect of Proton Pump Inhibitors On Barrett's Esophagus. Gastroenterol Clin North Am. 2015;44(2):415-24. PubMed PMID: 26021202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Proton Pump Inhibitors on Barrett's Esophagus. AU - Dunbar,Kerry B, AU - Souza,Rhonda F, AU - Spechler,Stuart J, Y1 - 2015/03/18/ PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/2/26/medline KW - Barrett’s esophagus KW - Dysplasia KW - Esophageal cancer KW - Gastroesophageal reflux disease KW - Proton pump inhibitor SP - 415 EP - 24 JF - Gastroenterology clinics of North America JO - Gastroenterol. Clin. North Am. VL - 44 IS - 2 N2 - Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus. SN - 1558-1942 UR - https://www.unboundmedicine.com/medline/citation/26021202/The_Effect_of_Proton_Pump_Inhibitors_on_Barrett's_Esophagus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8553(15)00027-8 DB - PRIME DP - Unbound Medicine ER -