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Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana.
BMC Nephrol. 2015 May 29; 16:75.BN

Abstract

BACKGROUND

Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, and how basic clinical variables differ across haemoglobin genotypes.

METHODS

A hospital-based cross-sectional study conducted from December 2013 to May 2014 at the Sickle cell clinic of the Tema General Hospital. One hundred and ninety-four (194) participants with SCD, receiving medical care at the outpatient sickle cell clinic were enrolled onto the study. A structured questionnaire was administered to obtain information on demography, clinical history, blood pressure and anthropometry. Blood and urine samples were taken for serum creatinine and proteinuria determination respectively. The estimated GFR (eGFR) was calculated using the CKD-EPI and Schwartz equations. CKD was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Analysis was performed using GraphPad prism and P <0.05 was considered statistically significant.

RESULTS

CKD was present in 39.2% of participants. Using KDIGO guidelines, 40.8% of the HbSS participants had stage 1 CKD and none had stage 2 CKD. In addition, 30.8% of the HbSC participants had stage 1 CKD and 3.8% had stage 2 CKD. There was a trend of increasing age across CKD stages and stage 2 CKD participants were oldest (P < 0.001).

CONCLUSION

Results from the current study suggest that CKD is common amongst SCD patients and prevalence and intensity increases with age. Proteinuria and CKD was more common in HbSS genotype than in HbSC genotype.

Authors+Show Affiliations

Medical Laboratory Division, Department of Medical Laboratory Technology, UCC, Cape Coast, Ghana. rephraim@ucc.edu.gh.Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, College of Health Sciences, Kumasi, Ghana. osakunor@gmail.com.Medical Laboratory Division, Department of Medical Laboratory Technology, UCC, Cape Coast, Ghana. obed.cudjoe@stu.ucc.edu.gh.Medical Laboratory Division, Department of Medical Laboratory Technology, UCC, Cape Coast, Ghana. enos.oduro@stu.ucc.edu.gh.Sickle Cell Unit, Tema General Hospital, Tema, Ghana. ludmilaasamani@yahoo.com.Sickle Cell Unit, Tema General Hospital, Tema, Ghana. enosamoako@gmail.com.Medical Laboratory Division, Department of Medical Laboratory Technology, UCC, Cape Coast, Ghana. edehopes@gmail.com.Medical Laboratory Division, Department of Medical Laboratory Technology, UCC, Cape Coast, Ghana. adobaprince@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26021375

Citation

Ephraim, Richard Kobina Dadzie, et al. "Chronic Kidney Disease Is Common in Sickle Cell Disease: a Cross-sectional Study in the Tema Metropolis, Ghana." BMC Nephrology, vol. 16, 2015, p. 75.
Ephraim RK, Osakunor DN, Cudjoe O, et al. Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana. BMC Nephrol. 2015;16:75.
Ephraim, R. K., Osakunor, D. N., Cudjoe, O., Oduro, E. A., Asante-Asamani, L., Mitchell, J., Agbodzakey, H., & Adoba, P. (2015). Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana. BMC Nephrology, 16, 75. https://doi.org/10.1186/s12882-015-0072-y
Ephraim RK, et al. Chronic Kidney Disease Is Common in Sickle Cell Disease: a Cross-sectional Study in the Tema Metropolis, Ghana. BMC Nephrol. 2015 May 29;16:75. PubMed PMID: 26021375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease is common in sickle cell disease: a cross-sectional study in the Tema Metropolis, Ghana. AU - Ephraim,Richard Kobina Dadzie, AU - Osakunor,Derick Nii Mensah, AU - Cudjoe,Obed, AU - Oduro,Enos Amoako, AU - Asante-Asamani,Lyudmila, AU - Mitchell,Juliana, AU - Agbodzakey,Hope, AU - Adoba,Prince, Y1 - 2015/05/29/ PY - 2014/12/05/received PY - 2015/05/21/accepted PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/1/27/medline SP - 75 EP - 75 JF - BMC nephrology JO - BMC Nephrol VL - 16 N2 - BACKGROUND: Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, and how basic clinical variables differ across haemoglobin genotypes. METHODS: A hospital-based cross-sectional study conducted from December 2013 to May 2014 at the Sickle cell clinic of the Tema General Hospital. One hundred and ninety-four (194) participants with SCD, receiving medical care at the outpatient sickle cell clinic were enrolled onto the study. A structured questionnaire was administered to obtain information on demography, clinical history, blood pressure and anthropometry. Blood and urine samples were taken for serum creatinine and proteinuria determination respectively. The estimated GFR (eGFR) was calculated using the CKD-EPI and Schwartz equations. CKD was defined according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Analysis was performed using GraphPad prism and P <0.05 was considered statistically significant. RESULTS: CKD was present in 39.2% of participants. Using KDIGO guidelines, 40.8% of the HbSS participants had stage 1 CKD and none had stage 2 CKD. In addition, 30.8% of the HbSC participants had stage 1 CKD and 3.8% had stage 2 CKD. There was a trend of increasing age across CKD stages and stage 2 CKD participants were oldest (P < 0.001). CONCLUSION: Results from the current study suggest that CKD is common amongst SCD patients and prevalence and intensity increases with age. Proteinuria and CKD was more common in HbSS genotype than in HbSC genotype. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/26021375/Chronic_kidney_disease_is_common_in_sickle_cell_disease:_a_cross_sectional_study_in_the_Tema_Metropolis_Ghana_ L2 - https://www.biomedcentral.com/1471-2369/16/75 DB - PRIME DP - Unbound Medicine ER -