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Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies.
Diabetologia 2015; 58(7):1394-408D

Abstract

AIMS/HYPOTHESIS

Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies.

METHODS

During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis.

RESULTS

In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HRQ4 vs Q1 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre.

CONCLUSIONS/INTERPRETATION

The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26021487

Citation

InterAct Consortium. "Dietary Fibre and Incidence of Type 2 Diabetes in Eight European Countries: the EPIC-InterAct Study and a Meta-analysis of Prospective Studies." Diabetologia, vol. 58, no. 7, 2015, pp. 1394-408.
InterAct Consortium. Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies. Diabetologia. 2015;58(7):1394-408.
InterAct Consortium. (2015). Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies. Diabetologia, 58(7), pp. 1394-408. doi:10.1007/s00125-015-3585-9.
InterAct Consortium. Dietary Fibre and Incidence of Type 2 Diabetes in Eight European Countries: the EPIC-InterAct Study and a Meta-analysis of Prospective Studies. Diabetologia. 2015;58(7):1394-408. PubMed PMID: 26021487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies. A1 - ,, Y1 - 2015/05/29/ PY - 2014/08/08/received PY - 2015/03/16/accepted PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/3/11/medline SP - 1394 EP - 408 JF - Diabetologia JO - Diabetologia VL - 58 IS - 7 N2 - AIMS/HYPOTHESIS: Intake of dietary fibre has been associated with a reduced risk of type 2 diabetes, but few European studies have been published on this. We evaluated the association between intake of dietary fibre and type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study and in a meta-analysis of prospective studies. METHODS: During 10.8 years of follow-up, 11,559 participants with type 2 diabetes were identified and a subcohort of 15,258 participants was selected for the case-cohort study. Country-specific HRs were estimated using Prentice-weighted Cox proportional hazards models and were pooled using a random effects meta-analysis. Eighteen other cohort studies were identified for the meta-analysis. RESULTS: In the EPIC-InterAct Study, dietary fibre intake was associated with a lower risk of diabetes (HRQ4 vs Q1 0.82; 95% CI 0.69, 0.97) after adjustment for lifestyle and dietary factors. Similar inverse associations were observed for the intake of cereal fibre and vegetable fibre, but not fruit fibre. The associations were attenuated and no longer statistically significant after adjustment for BMI. In the meta-analysis (19 cohorts), the summary RRs per 10 g/day increase in intake were 0.91 (95% CI 0.87, 0.96) for total fibre, 0.75 (95% CI 0.65, 0.86) for cereal fibre, 0.95 (95% CI 0.87, 1.03) for fruit fibre and 0.93 (95% CI 0.82, 1.05) for vegetable fibre. CONCLUSIONS/INTERPRETATION: The overall evidence indicates that the intake of total and cereal fibre is inversely related to the risk of type 2 diabetes. The results of the EPIC-InterAct Study suggest that the association may be partially explained by body weight. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/26021487/Dietary_fibre_and_incidence_of_type_2_diabetes_in_eight_European_countries:_the_EPIC_InterAct_Study_and_a_meta_analysis_of_prospective_studies_ L2 - https://dx.doi.org/10.1007/s00125-015-3585-9 DB - PRIME DP - Unbound Medicine ER -