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Grape powder treatment prevents anxiety-like behavior in a rat model of aging.
Nutr Res. 2015 Jun; 35(6):504-11.NR

Abstract

Earlier, we have reported that grape powder (GP) treatment prevented pharmacologic and psychological stress-induced anxiety-like behavior and memory impairment in rats. Protective effects of GP were attributed to its antioxidant effects. In this study, we tested the hypothesis that age-associated behavioral and cognitive deficits such as anxiety and memory impairment will be ameliorated with GP treatment. Using a National Institute of Aging recommended rodent model of aging, we examined a potentially protective role of antioxidant-rich GP in age-associated anxiety-like behavior and memory impairment. Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP). Anxiety-like behavior was significantly greater in aged rats compared with young rats, GP-treated young rats, or aged control rats (P < .05). Also, GP treatment prevented age-induced anxiety-like behavior in AG-GP rats (P < .05). Neither short-term nor long-term age-associated memory deficits improved with GP treatment in AG-GP rats. Furthermore, aged rats showed increased level of physiological stress (corticosterone) and increased oxidative stress in the plasma (8-isoprostane) as well as in selected brain areas (protein carbonylation). Grape powder treatment prevented age-induced increase in corticosterone levels and plasma 8-isoprostane levels in aged rats (P < .05), whereas protein carbonylation was recovered in the amygdala region only (P < .05). Grape powder by regulating oxidative stress ameliorates age-induced anxiety-like behavior in rats, whereas age-associated memory deficits seem unaffected with GP treatment.

Authors+Show Affiliations

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. Electronic address: masghar@uh.edu.Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. Electronic address: ssalim@uh.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26022140

Citation

Patki, Gaurav, et al. "Grape Powder Treatment Prevents Anxiety-like Behavior in a Rat Model of Aging." Nutrition Research (New York, N.Y.), vol. 35, no. 6, 2015, pp. 504-11.
Patki G, Ali Q, Pokkunuri I, et al. Grape powder treatment prevents anxiety-like behavior in a rat model of aging. Nutr Res. 2015;35(6):504-11.
Patki, G., Ali, Q., Pokkunuri, I., Asghar, M., & Salim, S. (2015). Grape powder treatment prevents anxiety-like behavior in a rat model of aging. Nutrition Research (New York, N.Y.), 35(6), 504-11. https://doi.org/10.1016/j.nutres.2015.05.005
Patki G, et al. Grape Powder Treatment Prevents Anxiety-like Behavior in a Rat Model of Aging. Nutr Res. 2015;35(6):504-11. PubMed PMID: 26022140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Grape powder treatment prevents anxiety-like behavior in a rat model of aging. AU - Patki,Gaurav, AU - Ali,Quaisar, AU - Pokkunuri,Indira, AU - Asghar,Mohammad, AU - Salim,Samina, Y1 - 2015/05/15/ PY - 2015/02/11/received PY - 2015/05/09/revised PY - 2015/05/11/accepted PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/3/2/medline KW - Aging KW - Anxiety KW - Cognition KW - Grape powder KW - Psychological stress SP - 504 EP - 11 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 35 IS - 6 N2 - Earlier, we have reported that grape powder (GP) treatment prevented pharmacologic and psychological stress-induced anxiety-like behavior and memory impairment in rats. Protective effects of GP were attributed to its antioxidant effects. In this study, we tested the hypothesis that age-associated behavioral and cognitive deficits such as anxiety and memory impairment will be ameliorated with GP treatment. Using a National Institute of Aging recommended rodent model of aging, we examined a potentially protective role of antioxidant-rich GP in age-associated anxiety-like behavior and memory impairment. Male Fischer 344 rats were randomly assigned into 4 groups: young rats (3 months old) provided with tap water or with 15 g/L GP dissolved in tap water for 3 weeks, aged rats (21 months old) provided with tap water or with GP-treated tap water for 3 weeks (AG-GP). Anxiety-like behavior was significantly greater in aged rats compared with young rats, GP-treated young rats, or aged control rats (P < .05). Also, GP treatment prevented age-induced anxiety-like behavior in AG-GP rats (P < .05). Neither short-term nor long-term age-associated memory deficits improved with GP treatment in AG-GP rats. Furthermore, aged rats showed increased level of physiological stress (corticosterone) and increased oxidative stress in the plasma (8-isoprostane) as well as in selected brain areas (protein carbonylation). Grape powder treatment prevented age-induced increase in corticosterone levels and plasma 8-isoprostane levels in aged rats (P < .05), whereas protein carbonylation was recovered in the amygdala region only (P < .05). Grape powder by regulating oxidative stress ameliorates age-induced anxiety-like behavior in rats, whereas age-associated memory deficits seem unaffected with GP treatment. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/26022140/Grape_powder_treatment_prevents_anxiety_like_behavior_in_a_rat_model_of_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(15)00100-1 DB - PRIME DP - Unbound Medicine ER -