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Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis.
Maturitas 2015; 81(3):353-61M

Abstract

We performed a systematic review and meta-analysis of the observational or interventional studies assessing the association of vasomotor symptoms (hot flushes and night sweats) with various cardiovascular risk markers (systolic (SBP) and diastolic blood pressure (DBP), hypertension, total cholesterol, body mass index (BMI), and measures of subclinical atherosclerosis), in peri-menopausal, menopausal, or postmenopausal women. Eleven unique studies were identified with data available on 19,667 non-overlapping participants. Pooled analysis showed that women with hot flushes, compared to those without, tended to have significant higher levels of SBP (mean difference (MD): 1.95 mmHg (95%CI, 0.27 to 33.63)), and DBP (MD 1.17 mmHg (95%CI, -0.21 to 2.54)) and higher odds of having hypertension (OR: 1.18, 95%CI: 0.93 to 1.51), albeit non-significant. Similarly, women who reported night sweats compared to those who did not, had significant higher levels of SBP, (MD: 1.33 mmHg (95%CI, 0.63 to 2.03)), DBP (MD: 0.55 mmHg (95%CI, 0.19 to 0.91)), total cholesterol (MD: 0.17 mmHg (95%CI, 0.03 to 0.31)) and

BMI (MD

0.64 mmHg (95%CI, 0.47 to 0.80)). Vasomotor symptoms in women were not associated with measures of subclinical atherosclerosis. Women with vasomotor symptoms may have an unfavorable cardiovascular risk profile compared to women without vasomotor complaints.

Authors+Show Affiliations

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: t.muka@erasmusmc.nl.Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Office NA-2914, Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26022385

Citation

Franco, Oscar H., et al. "Vasomotor Symptoms in Women and Cardiovascular Risk Markers: Systematic Review and Meta-analysis." Maturitas, vol. 81, no. 3, 2015, pp. 353-61.
Franco OH, Muka T, Colpani V, et al. Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. Maturitas. 2015;81(3):353-61.
Franco, O. H., Muka, T., Colpani, V., Kunutsor, S., Chowdhury, S., Chowdhury, R., & Kavousi, M. (2015). Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. Maturitas, 81(3), pp. 353-61. doi:10.1016/j.maturitas.2015.04.016.
Franco OH, et al. Vasomotor Symptoms in Women and Cardiovascular Risk Markers: Systematic Review and Meta-analysis. Maturitas. 2015;81(3):353-61. PubMed PMID: 26022385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. AU - Franco,Oscar H, AU - Muka,Taulant, AU - Colpani,Veronica, AU - Kunutsor,Setor, AU - Chowdhury,Susmita, AU - Chowdhury,Rajiv, AU - Kavousi,Maryam, Y1 - 2015/05/12/ PY - 2015/04/27/received PY - 2015/04/29/accepted PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/4/5/medline KW - Body mass index KW - Cardiovascular risk markers KW - Hot flushes KW - Hypertension KW - Night sweats KW - Vasomotor symptoms SP - 353 EP - 61 JF - Maturitas JO - Maturitas VL - 81 IS - 3 N2 - UNLABELLED: We performed a systematic review and meta-analysis of the observational or interventional studies assessing the association of vasomotor symptoms (hot flushes and night sweats) with various cardiovascular risk markers (systolic (SBP) and diastolic blood pressure (DBP), hypertension, total cholesterol, body mass index (BMI), and measures of subclinical atherosclerosis), in peri-menopausal, menopausal, or postmenopausal women. Eleven unique studies were identified with data available on 19,667 non-overlapping participants. Pooled analysis showed that women with hot flushes, compared to those without, tended to have significant higher levels of SBP (mean difference (MD): 1.95 mmHg (95%CI, 0.27 to 33.63)), and DBP (MD 1.17 mmHg (95%CI, -0.21 to 2.54)) and higher odds of having hypertension (OR: 1.18, 95%CI: 0.93 to 1.51), albeit non-significant. Similarly, women who reported night sweats compared to those who did not, had significant higher levels of SBP, (MD: 1.33 mmHg (95%CI, 0.63 to 2.03)), DBP (MD: 0.55 mmHg (95%CI, 0.19 to 0.91)), total cholesterol (MD: 0.17 mmHg (95%CI, 0.03 to 0.31)) and BMI (MD: 0.64 mmHg (95%CI, 0.47 to 0.80)). Vasomotor symptoms in women were not associated with measures of subclinical atherosclerosis. Women with vasomotor symptoms may have an unfavorable cardiovascular risk profile compared to women without vasomotor complaints. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/26022385/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(15)00670-2 DB - PRIME DP - Unbound Medicine ER -