Tags

Type your tag names separated by a space and hit enter

Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis.

Abstract

We performed a systematic review and meta-analysis of the observational or interventional studies assessing the association of vasomotor symptoms (hot flushes and night sweats) with various cardiovascular risk markers (systolic (SBP) and diastolic blood pressure (DBP), hypertension, total cholesterol, body mass index (BMI), and measures of subclinical atherosclerosis), in peri-menopausal, menopausal, or postmenopausal women. Eleven unique studies were identified with data available on 19,667 non-overlapping participants. Pooled analysis showed that women with hot flushes, compared to those without, tended to have significant higher levels of SBP (mean difference (MD): 1.95 mmHg (95%CI, 0.27 to 33.63)), and DBP (MD 1.17 mmHg (95%CI, -0.21 to 2.54)) and higher odds of having hypertension (OR: 1.18, 95%CI: 0.93 to 1.51), albeit non-significant. Similarly, women who reported night sweats compared to those who did not, had significant higher levels of SBP, (MD: 1.33 mmHg (95%CI, 0.63 to 2.03)), DBP (MD: 0.55 mmHg (95%CI, 0.19 to 0.91)), total cholesterol (MD: 0.17 mmHg (95%CI, 0.03 to 0.31)) and

BMI (MD

0.64 mmHg (95%CI, 0.47 to 0.80)). Vasomotor symptoms in women were not associated with measures of subclinical atherosclerosis. Women with vasomotor symptoms may have an unfavorable cardiovascular risk profile compared to women without vasomotor complaints.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

    ,

    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: t.muka@erasmusmc.nl.

    ,

    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Office NA-2914, Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.

    ,

    Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.

    ,

    Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.

    ,

    Department of Public Health & Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge CB1 8RN, United Kingdom.

    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

    Source

    Maturitas 81:3 2015 Jul pg 353-61

    MeSH

    Blood Pressure
    Body Mass Index
    Cholesterol
    Female
    Hot Flashes
    Humans
    Hypertension
    Menopause
    Risk Factors
    Sweating

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    26022385

    Citation

    Franco, Oscar H., et al. "Vasomotor Symptoms in Women and Cardiovascular Risk Markers: Systematic Review and Meta-analysis." Maturitas, vol. 81, no. 3, 2015, pp. 353-61.
    Franco OH, Muka T, Colpani V, et al. Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. Maturitas. 2015;81(3):353-61.
    Franco, O. H., Muka, T., Colpani, V., Kunutsor, S., Chowdhury, S., Chowdhury, R., & Kavousi, M. (2015). Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. Maturitas, 81(3), pp. 353-61. doi:10.1016/j.maturitas.2015.04.016.
    Franco OH, et al. Vasomotor Symptoms in Women and Cardiovascular Risk Markers: Systematic Review and Meta-analysis. Maturitas. 2015;81(3):353-61. PubMed PMID: 26022385.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis. AU - Franco,Oscar H, AU - Muka,Taulant, AU - Colpani,Veronica, AU - Kunutsor,Setor, AU - Chowdhury,Susmita, AU - Chowdhury,Rajiv, AU - Kavousi,Maryam, Y1 - 2015/05/12/ PY - 2015/04/27/received PY - 2015/04/29/accepted PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/4/5/medline KW - Body mass index KW - Cardiovascular risk markers KW - Hot flushes KW - Hypertension KW - Night sweats KW - Vasomotor symptoms SP - 353 EP - 61 JF - Maturitas JO - Maturitas VL - 81 IS - 3 N2 - UNLABELLED: We performed a systematic review and meta-analysis of the observational or interventional studies assessing the association of vasomotor symptoms (hot flushes and night sweats) with various cardiovascular risk markers (systolic (SBP) and diastolic blood pressure (DBP), hypertension, total cholesterol, body mass index (BMI), and measures of subclinical atherosclerosis), in peri-menopausal, menopausal, or postmenopausal women. Eleven unique studies were identified with data available on 19,667 non-overlapping participants. Pooled analysis showed that women with hot flushes, compared to those without, tended to have significant higher levels of SBP (mean difference (MD): 1.95 mmHg (95%CI, 0.27 to 33.63)), and DBP (MD 1.17 mmHg (95%CI, -0.21 to 2.54)) and higher odds of having hypertension (OR: 1.18, 95%CI: 0.93 to 1.51), albeit non-significant. Similarly, women who reported night sweats compared to those who did not, had significant higher levels of SBP, (MD: 1.33 mmHg (95%CI, 0.63 to 2.03)), DBP (MD: 0.55 mmHg (95%CI, 0.19 to 0.91)), total cholesterol (MD: 0.17 mmHg (95%CI, 0.03 to 0.31)) and BMI (MD: 0.64 mmHg (95%CI, 0.47 to 0.80)). Vasomotor symptoms in women were not associated with measures of subclinical atherosclerosis. Women with vasomotor symptoms may have an unfavorable cardiovascular risk profile compared to women without vasomotor complaints. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/26022385/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(15)00670-2 DB - PRIME DP - Unbound Medicine ER -