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Epigenetic landscape of amphetamine and methamphetamine addiction in rodents.
Epigenetics. 2015; 10(7):574-80.E

Abstract

Amphetamine and methamphetamine addiction is described by specific behavioral alterations, suggesting long-lasting changes in gene and protein expression within specific brain subregions involved in the reward circuitry. Given the persistence of the addiction phenotype at both behavioral and transcriptional levels, several studies have been conducted to elucidate the epigenetic landscape associated with persistent effects of drug use on the mammalian brain. This review discusses recent advances in our comprehension of epigenetic mechanisms underlying amphetamine- or methamphetamine-induced behavioral, transcriptional, and synaptic plasticity. Accumulating evidence demonstrated that drug exposure induces major epigenetic modifications-histone acetylation and methylation, DNA methylation-in a very complex manner. In rare instances, however, the regulation of a specific target gene can be correlated to both epigenetic alterations and behavioral abnormalities. Work is now needed to clarify and validate an epigenetic model of addiction to amphetamines. Investigations that include genome-wide approaches will accelerate the speed of discovery in the field of addiction.

Authors+Show Affiliations

a Département de Biologie; École Normale Supérieure de Lyon ; Lyon , France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

26023847

Citation

Godino, Arthur, et al. "Epigenetic Landscape of Amphetamine and Methamphetamine Addiction in Rodents." Epigenetics, vol. 10, no. 7, 2015, pp. 574-80.
Godino A, Jayanthi S, Cadet JL. Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. Epigenetics. 2015;10(7):574-80.
Godino, A., Jayanthi, S., & Cadet, J. L. (2015). Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. Epigenetics, 10(7), 574-80. https://doi.org/10.1080/15592294.2015.1055441
Godino A, Jayanthi S, Cadet JL. Epigenetic Landscape of Amphetamine and Methamphetamine Addiction in Rodents. Epigenetics. 2015;10(7):574-80. PubMed PMID: 26023847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. AU - Godino,Arthur, AU - Jayanthi,Subramaniam, AU - Cadet,Jean Lud, PY - 2015/5/30/entrez PY - 2015/5/30/pubmed PY - 2016/3/17/medline KW - AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid KW - AMPH, amphetamine KW - AP1, activator protein 1 KW - ATF2, activating transcription factor 2 KW - BASP1, brain abundant signal protein 1 KW - BDNF, brain derived neurotrophic factor KW - CCR2, C‒C chemokine receptor 2 KW - CPP, conditioned place preference KW - CREB, cAMP response element binding protein KW - ChIP, chromatin immunoprecipitation KW - CoREST, restrictive element 1 silencing transcription factor corepressor KW - Cp60, compound 60 KW - DNA methylation KW - DNMT, DNA methyltransferase KW - FOS, Finkel–Biskis–Jinkins murine osteosarcoma viral oncogene KW - GABA, γ-aminobutyric acid KW - GLUA1, glutamate receptor subunit A1 KW - GLUA2, glutamate receptor subunit A2 KW - GLUN1, glutamate receptor subunit N1 KW - H2Bac, pan-acetylation of histone 2B KW - H3, histone 3 KW - H3K14Ac, acetylation of histone 3 at lysine 14 KW - H3K18, lysine 18 of histone 3 KW - H3K4, lysine 4 of histone 3 KW - H3K4me3, trimethylation of histone 3 at lysine 4 KW - H3K9, lysine 9 of histone 3 KW - H3K9Ac, acetylation of histone 3 at lysine 9 KW - H3K9me3, trimethylation of histone 3 at lysine 9 KW - H4, histone 4 KW - H4Ac, pan-acetylation of histone 4 KW - H4K12Ac, acetylation of histone 4 at lysine 12 KW - H4K16, lysine 16 of histone 4 KW - H4K5, lysine 5 of histone 4 KW - H4K8, lysine 8 of histone 4 KW - HAT, histone acetyltransferase KW - HDAC, histone deacetylase KW - HDM, histone demethylase KW - HMT, histone methyltransferase KW - IP, intra-peritoneal KW - JUN, jun proto-oncogene KW - KDM, lysine demethylase KW - KLF10, Kruppel-like factor 10 KW - KMT, lysine methyltransferase KW - METH, methamphetamine KW - MeCP2, methyl-CpG binding protein 2 KW - NAc, nucleus accumbens KW - NMDA, N-methyl-D-aspartate KW - NaB, sodium butyrate KW - OfC, orbitofrontal cortex KW - PfC, prefrontal cortex KW - REST, restrictive element 1 silencing transcription factor KW - RNAi, RNA interference KW - Ser241, serine 241 KW - Sin3A, SIN3 transcription regulator family member A KW - TSS, transcription start site KW - VPA, valproic acid KW - WT1, Wilms tumor protein 1. KW - amphetamine KW - histone acetylation KW - histone methylation KW - methamphetamine KW - siRNA, silencing RNA SP - 574 EP - 80 JF - Epigenetics JO - Epigenetics VL - 10 IS - 7 N2 - Amphetamine and methamphetamine addiction is described by specific behavioral alterations, suggesting long-lasting changes in gene and protein expression within specific brain subregions involved in the reward circuitry. Given the persistence of the addiction phenotype at both behavioral and transcriptional levels, several studies have been conducted to elucidate the epigenetic landscape associated with persistent effects of drug use on the mammalian brain. This review discusses recent advances in our comprehension of epigenetic mechanisms underlying amphetamine- or methamphetamine-induced behavioral, transcriptional, and synaptic plasticity. Accumulating evidence demonstrated that drug exposure induces major epigenetic modifications-histone acetylation and methylation, DNA methylation-in a very complex manner. In rare instances, however, the regulation of a specific target gene can be correlated to both epigenetic alterations and behavioral abnormalities. Work is now needed to clarify and validate an epigenetic model of addiction to amphetamines. Investigations that include genome-wide approaches will accelerate the speed of discovery in the field of addiction. SN - 1559-2308 UR - https://www.unboundmedicine.com/medline/citation/26023847/Epigenetic_landscape_of_amphetamine_and_methamphetamine_addiction_in_rodents_ L2 - https://www.tandfonline.com/doi/full/10.1080/15592294.2015.1055441 DB - PRIME DP - Unbound Medicine ER -