Tags

Type your tag names separated by a space and hit enter

Diffuse Lewy body disease: an important differential diagnosis in dementia with extrapyramidal features.
Prog Clin Biol Res. 1989; 317:121-30.PC

Abstract

Fifteen cases of diffuse Lewy body disease were identified in a systematic survey of all 216 brains referred to this hospital from a single health district in a single year. These cases presented with Parkinson's disease (40%), cognitive impairment (40%) and both (20%). Quantitative neuropathological studies using anti-ubiquitin immunocytochemistry revealed that dementia severity was related to cortical Lewy body density. The prevalence of diffuse Lewy body disease may have been underestimated in the past because of the neuropathological difficulties in making the diagnosis. Firstly, cortical Lewy bodies have a subtle appearance and are easy to overlook. Secondly, senile plaques are a common feature of diffuse Lewy body disease and may lead the unwary to make an erroneous diagnosis of Alzheimer's disease or "plaque-only Alzheimer's disease'. Diffuse Lewy body disease is a common and important cause of parkinsonian dementia, including the dementia of Parkinson's disease itself.

Authors+Show Affiliations

Department of Neurology, Queen's Medical Centre, Nottingham, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2602409

Citation

Lennox, G, et al. "Diffuse Lewy Body Disease: an Important Differential Diagnosis in Dementia With Extrapyramidal Features." Progress in Clinical and Biological Research, vol. 317, 1989, pp. 121-30.
Lennox G, Lowe JS, Godwin-Austen RB, et al. Diffuse Lewy body disease: an important differential diagnosis in dementia with extrapyramidal features. Prog Clin Biol Res. 1989;317:121-30.
Lennox, G., Lowe, J. S., Godwin-Austen, R. B., Landon, M., & Mayer, R. J. (1989). Diffuse Lewy body disease: an important differential diagnosis in dementia with extrapyramidal features. Progress in Clinical and Biological Research, 317, 121-30.
Lennox G, et al. Diffuse Lewy Body Disease: an Important Differential Diagnosis in Dementia With Extrapyramidal Features. Prog Clin Biol Res. 1989;317:121-30. PubMed PMID: 2602409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffuse Lewy body disease: an important differential diagnosis in dementia with extrapyramidal features. AU - Lennox,G, AU - Lowe,J S, AU - Godwin-Austen,R B, AU - Landon,M, AU - Mayer,R J, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 121 EP - 30 JF - Progress in clinical and biological research JO - Prog Clin Biol Res VL - 317 N2 - Fifteen cases of diffuse Lewy body disease were identified in a systematic survey of all 216 brains referred to this hospital from a single health district in a single year. These cases presented with Parkinson's disease (40%), cognitive impairment (40%) and both (20%). Quantitative neuropathological studies using anti-ubiquitin immunocytochemistry revealed that dementia severity was related to cortical Lewy body density. The prevalence of diffuse Lewy body disease may have been underestimated in the past because of the neuropathological difficulties in making the diagnosis. Firstly, cortical Lewy bodies have a subtle appearance and are easy to overlook. Secondly, senile plaques are a common feature of diffuse Lewy body disease and may lead the unwary to make an erroneous diagnosis of Alzheimer's disease or "plaque-only Alzheimer's disease'. Diffuse Lewy body disease is a common and important cause of parkinsonian dementia, including the dementia of Parkinson's disease itself. SN - 0361-7742 UR - https://www.unboundmedicine.com/medline/citation/2602409/Diffuse_Lewy_body_disease:_an_important_differential_diagnosis_in_dementia_with_extrapyramidal_features_ L2 - https://www.diseaseinfosearch.org/result/4215 DB - PRIME DP - Unbound Medicine ER -