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Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans.
Mol Cell Endocrinol. 2015 Dec 15; 418 Pt 2:184-90.MC

Abstract

Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue (BAT) has brought the relation between ambient temperature, thermogenesis and systemic energy and substrate metabolism to the forefront. In addition to well-known pituitary-thyroid-adrenal axis, new endocrine signals, such as FGF21 and irisin, orchestrate crosstalk between white adipose tissue (WAT), BAT and muscle, tuning non-shivering and shivering thermogenesis responses. Cold exposure modulates the endocrine milieu, and cold-induced hormones cause bioenergetics transformation sufficient to impact whole body metabolism. This review will appraise the nature of human BAT and the basis of BAT-centred therapeutics, highlighting how the interaction between hormones and adipose tissue impacts metabolic responses. Non-pharmacological and pharmacological strategies of BAT recruitment and/or fat browning for metabolic benefits will be discussed.

Authors+Show Affiliations

Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia; Department of Endocrinology, St Vincent's Hospital, New South Wales, Australia. Electronic address: p.lee@garvan.org.au.Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia; Department of Endocrinology, St Vincent's Hospital, New South Wales, Australia; Diabetes Centre, St Vincent's Hospital, New South Wales, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26026310

Citation

Lee, Paul, and Jerry R. Greenfield. "Non-pharmacological and Pharmacological Strategies of Brown Adipose Tissue Recruitment in Humans." Molecular and Cellular Endocrinology, vol. 418 Pt 2, 2015, pp. 184-90.
Lee P, Greenfield JR. Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Mol Cell Endocrinol. 2015;418 Pt 2:184-90.
Lee, P., & Greenfield, J. R. (2015). Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Molecular and Cellular Endocrinology, 418 Pt 2, 184-90. https://doi.org/10.1016/j.mce.2015.05.025
Lee P, Greenfield JR. Non-pharmacological and Pharmacological Strategies of Brown Adipose Tissue Recruitment in Humans. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 2:184-90. PubMed PMID: 26026310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. AU - Lee,Paul, AU - Greenfield,Jerry R, Y1 - 2015/05/27/ PY - 2014/12/11/received PY - 2015/03/31/revised PY - 2015/05/04/accepted PY - 2015/6/1/entrez PY - 2015/6/1/pubmed PY - 2016/10/7/medline KW - Beige adipose tissue KW - Energy balance KW - FGF21 KW - Irisin KW - Metabolism KW - Thermogenesis SP - 184 EP - 90 JF - Molecular and cellular endocrinology JO - Mol. Cell. Endocrinol. VL - 418 Pt 2 N2 - Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue (BAT) has brought the relation between ambient temperature, thermogenesis and systemic energy and substrate metabolism to the forefront. In addition to well-known pituitary-thyroid-adrenal axis, new endocrine signals, such as FGF21 and irisin, orchestrate crosstalk between white adipose tissue (WAT), BAT and muscle, tuning non-shivering and shivering thermogenesis responses. Cold exposure modulates the endocrine milieu, and cold-induced hormones cause bioenergetics transformation sufficient to impact whole body metabolism. This review will appraise the nature of human BAT and the basis of BAT-centred therapeutics, highlighting how the interaction between hormones and adipose tissue impacts metabolic responses. Non-pharmacological and pharmacological strategies of BAT recruitment and/or fat browning for metabolic benefits will be discussed. SN - 1872-8057 UR - https://www.unboundmedicine.com/medline/citation/26026310/Non_pharmacological_and_pharmacological_strategies_of_brown_adipose_tissue_recruitment_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(15)00292-0 DB - PRIME DP - Unbound Medicine ER -