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Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).
Behav Neurosci 2015; 129(3):368-70BN

Abstract

Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects.

Authors+Show Affiliations

Department of Psychology, University of Guelph.Department of Psychology, University of Guelph.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26030435

Citation

Rock, Erin M., and Linda A. Parker. "Synergy Between Cannabidiol, Cannabidiolic Acid, and Δ⁹-tetrahydrocannabinol in the Regulation of Emesis in the Suncus Murinus (house Musk Shrew)." Behavioral Neuroscience, vol. 129, no. 3, 2015, pp. 368-70.
Rock EM, Parker LA. Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew). Behav Neurosci. 2015;129(3):368-70.
Rock, E. M., & Parker, L. A. (2015). Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew). Behavioral Neuroscience, 129(3), pp. 368-70. doi:10.1037/bne0000057.
Rock EM, Parker LA. Synergy Between Cannabidiol, Cannabidiolic Acid, and Δ⁹-tetrahydrocannabinol in the Regulation of Emesis in the Suncus Murinus (house Musk Shrew). Behav Neurosci. 2015;129(3):368-70. PubMed PMID: 26030435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew). AU - Rock,Erin M, AU - Parker,Linda A, PY - 2015/6/2/entrez PY - 2015/6/2/pubmed PY - 2016/2/18/medline SP - 368 EP - 70 JF - Behavioral neuroscience JO - Behav. Neurosci. VL - 129 IS - 3 N2 - Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects. SN - 1939-0084 UR - https://www.unboundmedicine.com/medline/citation/26030435/Synergy_between_cannabidiol_cannabidiolic_acid_and_Δ⁹_tetrahydrocannabinol_in_the_regulation_of_emesis_in_the_Suncus_murinus__house_musk_shrew__ L2 - http://content.apa.org/journals/bne/129/3/368 DB - PRIME DP - Unbound Medicine ER -