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Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices.
J Matern Fetal Neonatal Med 2016; 29(7):1190-4JM

Abstract

OBJECTIVE

To assess the capacity of maternal ophthalmic Doppler indices for predicting small for gestational age (SGA) newborns in the first trimester of pregnancy.

METHODS

We performed a prospective observational cohort study involving 499 singleton pregnancies during the first trimester scan (11-14 weeks). The following maternal ophthalmic Doppler indices were assessed: pulsatility index (PI), first diastolic peak velocity (PD1) and peak ratio (PR) = PD1/peak systolic velocity. We considered SGA all newborns with weight below 10th percentile. We used chi-square test (χ(2)) to compare the groups. We used area under receiver operating characteristics (ROC) curves with 95% confidence intervals (CI) and detection rate of 5% of false positive of each maternal ophthalmic Doppler index and the mean uterine artery PI for prediction SGA.

RESULTS

27 (5.4%) patients delivered SGA newborns, 12 (2.4%) patients developed preeclampsia (PE) and delivered SGA newborns, and 460 had uneventful pregnancies (controls). We observed significant difference of PI and PR between SGA (SGA and SGA+PE) and control groups, p = 0.043 and p = 0.014, respectively. To 5% of false positive, the detection rate of SGA (SGA and SGA+PE groups) using PI, PD1 and PR were 14.8, 3.7, 14.8, 16.7, 16.7 and 16.7%, respectively. Mean uterine PI was significantly higher in the SGA+PE group (p = 0.003).

CONCLUSION

The isolated use of maternal ophthalmic Doppler indices or in combination with uterine artery Doppler, in the first trimester of pregnancy, was not efficient to predict SGA newborns.

Authors+Show Affiliations

a Department of Public Health , State University of Ceará (UECE) , Fortaleza - CE , Brazil .a Department of Public Health , State University of Ceará (UECE) , Fortaleza - CE , Brazil .b Department of Obstetrics , Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP) , São Paulo - SP , Brazil .c Department of Obstetrics and Gynecology , Guastalla Civil Hospital , ASL Reggio Emilia , Italy .d Department of Obstetrics and Gynecology , Ribeirão Preto School of Medicine, University of São Paulo (DGO-FMRP-USP) , Ribeirão Preto - SP , Brazil , and.e Ultrasound Services and Department of Perinatal Medicine , Royal Women's Hospital , Melbourne , VIC , Australia , and. f Department of Obstetrics and Gynecology , University of Melbourne (UNIMELB) , Melbourne , VIC , Australia.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

26030678

Citation

Gurgel Alves, Júlio Augusto, et al. "Predicting Small for Gestational Age in the First Trimester of Pregnancy Using Maternal Ophthalmic Artery Doppler Indices." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 29, no. 7, 2016, pp. 1190-4.
Gurgel Alves JA, Maia e Holanda Moura SB, Araujo Júnior E, et al. Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices. J Matern Fetal Neonatal Med. 2016;29(7):1190-4.
Gurgel Alves, J. A., Maia e Holanda Moura, S. B., Araujo Júnior, E., Tonni, G., Martins, W. P., & Da Silva Costa, F. (2016). Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(7), pp. 1190-4. doi:10.3109/14767058.2015.1040755.
Gurgel Alves JA, et al. Predicting Small for Gestational Age in the First Trimester of Pregnancy Using Maternal Ophthalmic Artery Doppler Indices. J Matern Fetal Neonatal Med. 2016;29(7):1190-4. PubMed PMID: 26030678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting small for gestational age in the first trimester of pregnancy using maternal ophthalmic artery Doppler indices. AU - Gurgel Alves,Júlio Augusto, AU - Maia e Holanda Moura,Sammya Bezerra, AU - Araujo Júnior,Edward, AU - Tonni,Gabriele, AU - Martins,Wellington P, AU - Da Silva Costa,Fabrício, Y1 - 2015/06/01/ PY - 2015/6/2/entrez PY - 2015/6/2/pubmed PY - 2016/12/15/medline KW - First trimester KW - maternal ophthalmic Doppler KW - prediction KW - small for gestational age KW - uterine artery Doppler SP - 1190 EP - 4 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 29 IS - 7 N2 - OBJECTIVE: To assess the capacity of maternal ophthalmic Doppler indices for predicting small for gestational age (SGA) newborns in the first trimester of pregnancy. METHODS: We performed a prospective observational cohort study involving 499 singleton pregnancies during the first trimester scan (11-14 weeks). The following maternal ophthalmic Doppler indices were assessed: pulsatility index (PI), first diastolic peak velocity (PD1) and peak ratio (PR) = PD1/peak systolic velocity. We considered SGA all newborns with weight below 10th percentile. We used chi-square test (χ(2)) to compare the groups. We used area under receiver operating characteristics (ROC) curves with 95% confidence intervals (CI) and detection rate of 5% of false positive of each maternal ophthalmic Doppler index and the mean uterine artery PI for prediction SGA. RESULTS: 27 (5.4%) patients delivered SGA newborns, 12 (2.4%) patients developed preeclampsia (PE) and delivered SGA newborns, and 460 had uneventful pregnancies (controls). We observed significant difference of PI and PR between SGA (SGA and SGA+PE) and control groups, p = 0.043 and p = 0.014, respectively. To 5% of false positive, the detection rate of SGA (SGA and SGA+PE groups) using PI, PD1 and PR were 14.8, 3.7, 14.8, 16.7, 16.7 and 16.7%, respectively. Mean uterine PI was significantly higher in the SGA+PE group (p = 0.003). CONCLUSION: The isolated use of maternal ophthalmic Doppler indices or in combination with uterine artery Doppler, in the first trimester of pregnancy, was not efficient to predict SGA newborns. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/26030678/Predicting_small_for_gestational_age_in_the_first_trimester_of_pregnancy_using_maternal_ophthalmic_artery_Doppler_indices_ L2 - http://www.tandfonline.com/doi/full/10.3109/14767058.2015.1040755 DB - PRIME DP - Unbound Medicine ER -