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Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases.
Dig Dis Sci 2015; 60(10):3085-91DD

Abstract

BACKGROUND

Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD).

AIMS

To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.

METHODS

This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan city, Iran. Disease activity was evaluated using the Simplified Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index. Quality of life was assessed with the Short-Inflammatory Bowel Disease Questionnaire. Serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency and insufficiency were defined as concentration of <50 and 50-75 nmol/L, respectively.

RESULTS

Studied subjects were 85 ulcerative colitis and 48 Crohn's disease patients (54.1% females) with mean age of 42.0 ± 14.0 years. Vitamin D deficiency and insufficiency were present in 52 (39.0%) and 24 (18.0%) patients, respectively. Thirty patients (22.5%) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs. 50.4%, P = 0.005). Quality of life was not different between patients with low and those with normal vitamin D levels (P = 0.693). In the logistic regression model, low vitamin D was independently associated with active disease status, OR (95% CI) = 5.959 (1.695-20.952).

CONCLUSIONS

We found an association between vitamin D deficiency/insufficiency and disease activity in IBD patients. Prospective cohorts and clinical trials are required to clarify the role of vitamin D deficiency and its treatment in clinical course of IBD.

Authors+Show Affiliations

Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. rzenderoud@yahoo.com. Poursina Hakim Research Institute, Sheikh Mofid Avenue, Isfahan, Iran. rzenderoud@yahoo.com.Poursina Hakim Research Institute, Sheikh Mofid Avenue, Isfahan, Iran. ali.gholamrezaei@ymail.com. Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. ali.gholamrezaei@ymail.com.Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. leilamirbager@gmail.com.Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. danesh.manizheh@gmail.com.Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. sara2013kh8@gmail.com.Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. mh_emami@med.mui.ac.ir. Poursina Hakim Research Institute, Sheikh Mofid Avenue, Isfahan, Iran. mh_emami@med.mui.ac.ir.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26031421

Citation

Torki, Mehdi, et al. "Vitamin D Deficiency Associated With Disease Activity in Patients With Inflammatory Bowel Diseases." Digestive Diseases and Sciences, vol. 60, no. 10, 2015, pp. 3085-91.
Torki M, Gholamrezaei A, Mirbagher L, et al. Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases. Dig Dis Sci. 2015;60(10):3085-91.
Torki, M., Gholamrezaei, A., Mirbagher, L., Danesh, M., Kheiri, S., & Emami, M. H. (2015). Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases. Digestive Diseases and Sciences, 60(10), pp. 3085-91. doi:10.1007/s10620-015-3727-4.
Torki M, et al. Vitamin D Deficiency Associated With Disease Activity in Patients With Inflammatory Bowel Diseases. Dig Dis Sci. 2015;60(10):3085-91. PubMed PMID: 26031421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases. AU - Torki,Mehdi, AU - Gholamrezaei,Ali, AU - Mirbagher,Leila, AU - Danesh,Manijeh, AU - Kheiri,Sara, AU - Emami,Mohammad Hassan, Y1 - 2015/06/02/ PY - 2015/04/24/received PY - 2015/05/21/accepted PY - 2015/6/3/entrez PY - 2015/6/3/pubmed PY - 2015/12/17/medline KW - 25-Hydroxyvitamin D KW - Crohn’s disease KW - Inflammatory bowel diseases KW - Quality of life KW - Ulcerative colitis KW - Vitamin D SP - 3085 EP - 91 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 60 IS - 10 N2 - BACKGROUND: Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD). AIMS: To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients. METHODS: This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan city, Iran. Disease activity was evaluated using the Simplified Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index. Quality of life was assessed with the Short-Inflammatory Bowel Disease Questionnaire. Serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency and insufficiency were defined as concentration of <50 and 50-75 nmol/L, respectively. RESULTS: Studied subjects were 85 ulcerative colitis and 48 Crohn's disease patients (54.1% females) with mean age of 42.0 ± 14.0 years. Vitamin D deficiency and insufficiency were present in 52 (39.0%) and 24 (18.0%) patients, respectively. Thirty patients (22.5%) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs. 50.4%, P = 0.005). Quality of life was not different between patients with low and those with normal vitamin D levels (P = 0.693). In the logistic regression model, low vitamin D was independently associated with active disease status, OR (95% CI) = 5.959 (1.695-20.952). CONCLUSIONS: We found an association between vitamin D deficiency/insufficiency and disease activity in IBD patients. Prospective cohorts and clinical trials are required to clarify the role of vitamin D deficiency and its treatment in clinical course of IBD. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/26031421/Vitamin_D_Deficiency_Associated_with_Disease_Activity_in_Patients_with_Inflammatory_Bowel_Diseases_ L2 - https://doi.org/10.1007/s10620-015-3727-4 DB - PRIME DP - Unbound Medicine ER -