Tags

Type your tag names separated by a space and hit enter

High body mass index and allergies in schoolchildren: the French six cities study.
BMJ Open Respir Res 2014; 1(1):e000054BO

Abstract

BACKGROUND

The prevalence of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis is increasing rapidly worldwide, especially among children and in western countries. This coincides with an increase in body mass index (BMI), which might be a major risk factor for atopic diseases.

OBJECTIVES

To study the relationship between high BMI and allergic diseases, as well as skin-prick test (SPT) positivity and exercise-induced asthma (EIA) in 6733 randomly selected schoolchildren aged 9-11 years in the French Six Cities Study.

METHODS

A cross-sectional study was carried out in Bordeaux, Clermont-Ferrand, Créteil, Marseille, Reims and Strasbourg. Parental questionnaires based on the International Study on Asthma and Allergies in Childhood (ISAAC) were used to collect information on allergic diseases and potential risk factors. Skin-prick testing to common allergens was performed to identify the existence of an allergic hypersensitivity and an exercise test was also performed to assess EIA. Height and weight were collected by trained investigators. After computing the BMI (weight/height squared), the International Obesity Task Force (IOTF) cut-offs were used to define overweight and obesity. The children were also classified as wheezing or non-wheezing.

RESULTS

After adjustment for confounding factors, lifetime asthma was associated with high BMI among non-wheezing children (adjusted OR, aOR=1.98, 95% CI (1.06 to 3.70)). In addition, lifetime and past-year allergic rhinitis was associated with high BMI in wheezing children (aOR=1.63, (1.09 to 2.45) and aOR=2.20, (1.13 to 4.27)). However, high BMI was not significantly associated with eczema, SPT positivity or EIA.

CONCLUSIONS

This study shows a positive association between high BMI and lifetime asthma in non-wheezing children. High BMI was also associated with lifetime and past-year allergic rhinitis. Further studies are needed to provide causal evidence.

Authors+Show Affiliations

Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy , Lebanese University , Hadath , Lebanon ; INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Université de Bordeaux , Bordeaux , France.Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy , Lebanese University , Hadath , Lebanon.Hôpital Gabriel Montpied , Clermont-Ferrand , France.Hôpital Nord , Marseille , France.Hôpital Civil , Strasbourg , France.Hôpital Civil , Strasbourg , France.Hôpital Maison Blanche , Reims , France.EPAR, UMR-S 1136, Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Universites , Paris , France.INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Université de Bordeaux , Bordeaux , France.INSERM U897, Institut de Santé Publique d'Epidémiologie et de Développement, Université de Bordeaux , Bordeaux , France ; Service des maladies respiratoires , Hôpital du Haut-Lévèque, Avenue de Magellan , Pessac , France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26034606

Citation

Saadeh, Danielle, et al. "High Body Mass Index and Allergies in Schoolchildren: the French Six Cities Study." BMJ Open Respiratory Research, vol. 1, no. 1, 2014, pp. e000054.
Saadeh D, Salameh P, Caillaud D, et al. High body mass index and allergies in schoolchildren: the French six cities study. BMJ Open Respir Res. 2014;1(1):e000054.
Saadeh, D., Salameh, P., Caillaud, D., Charpin, D., de Blay, F., Kopferschmitt, C., ... Raherison, C. (2014). High body mass index and allergies in schoolchildren: the French six cities study. BMJ Open Respiratory Research, 1(1), pp. e000054. doi:10.1136/bmjresp-2014-000054.
Saadeh D, et al. High Body Mass Index and Allergies in Schoolchildren: the French Six Cities Study. BMJ Open Respir Res. 2014;1(1):e000054. PubMed PMID: 26034606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High body mass index and allergies in schoolchildren: the French six cities study. AU - Saadeh,Danielle, AU - Salameh,Pascale, AU - Caillaud,Denis, AU - Charpin,Denis, AU - de Blay,Frédéric, AU - Kopferschmitt,Christine, AU - Lavaud,François, AU - Annesi-Maesano,Isabella, AU - Baldi,Isabelle, AU - Raherison,Chantal, Y1 - 2014/12/24/ PY - 2014/07/23/received PY - 2014/10/03/accepted PY - 2015/6/3/entrez PY - 2014/1/1/pubmed PY - 2014/1/1/medline KW - Allergic Alveolitis KW - Asthma KW - Asthma Epidemiology KW - Immunodeficiency SP - e000054 EP - e000054 JF - BMJ open respiratory research JO - BMJ Open Respir Res VL - 1 IS - 1 N2 - BACKGROUND: The prevalence of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis is increasing rapidly worldwide, especially among children and in western countries. This coincides with an increase in body mass index (BMI), which might be a major risk factor for atopic diseases. OBJECTIVES: To study the relationship between high BMI and allergic diseases, as well as skin-prick test (SPT) positivity and exercise-induced asthma (EIA) in 6733 randomly selected schoolchildren aged 9-11 years in the French Six Cities Study. METHODS: A cross-sectional study was carried out in Bordeaux, Clermont-Ferrand, Créteil, Marseille, Reims and Strasbourg. Parental questionnaires based on the International Study on Asthma and Allergies in Childhood (ISAAC) were used to collect information on allergic diseases and potential risk factors. Skin-prick testing to common allergens was performed to identify the existence of an allergic hypersensitivity and an exercise test was also performed to assess EIA. Height and weight were collected by trained investigators. After computing the BMI (weight/height squared), the International Obesity Task Force (IOTF) cut-offs were used to define overweight and obesity. The children were also classified as wheezing or non-wheezing. RESULTS: After adjustment for confounding factors, lifetime asthma was associated with high BMI among non-wheezing children (adjusted OR, aOR=1.98, 95% CI (1.06 to 3.70)). In addition, lifetime and past-year allergic rhinitis was associated with high BMI in wheezing children (aOR=1.63, (1.09 to 2.45) and aOR=2.20, (1.13 to 4.27)). However, high BMI was not significantly associated with eczema, SPT positivity or EIA. CONCLUSIONS: This study shows a positive association between high BMI and lifetime asthma in non-wheezing children. High BMI was also associated with lifetime and past-year allergic rhinitis. Further studies are needed to provide causal evidence. SN - 2052-4439 UR - https://www.unboundmedicine.com/medline/citation/26034606/High_body_mass_index_and_allergies_in_schoolchildren:_the_French_six_cities_study_ L2 - https://bmjopenrespres.bmj.com/cgi/pmidlookup?view=long&pmid=26034606 DB - PRIME DP - Unbound Medicine ER -