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Hyperhomocysteinemia: Impact on Neurodegenerative Diseases.

Abstract

Neurodegenerative diseases are the diseases of the central nervous system with various aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) and autism are some examples of neurodegenerative diseases. Hyperhomocysteinemia (Hhcy) is considered to be an independent risk factor for numerous pathological conditions under neurodegenerative diseases. Along with genetic factors that are the prime cause of homocysteine (Hcy) imbalance, the nutritional and hormonal factors are also contributing to high Hcy levels in the body. Numerous clinical and epidemiological data confirm the direct correlation of Hcy levels in the body and generation of different types of central nervous system disorders, cardiovascular diseases, cancer and others. Till now, it is difficult to say whether homocysteine is the cause of the disease or whether it is one of the impacts of the diseases. However, Hhcy is a surrogate marker of vitamin B deficiency and is a neurotoxic agent. This Mini Review will give an overview of how far research has gone into understanding the homocysteine imbalance with prognostic, causative and preventive measures in treating neurodegenerative diseases.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, India. Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, USA.

    ,

    Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, India.

    Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, USA.

    Source

    MeSH

    Animals
    Biomarkers
    Homocysteine
    Humans
    Hyperhomocysteinemia
    Neurodegenerative Diseases
    Nutritional Status
    Prognosis
    Risk Factors
    Vitamin B Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26036286

    Citation

    TY - JOUR T1 - Hyperhomocysteinemia: Impact on Neurodegenerative Diseases. AU - Sharma,Meenakshi, AU - Tiwari,Manisha, AU - Tiwari,Rakesh Kumar, Y1 - 2015/06/19/ PY - 2015/3/1/received PY - 2015/5/19/accepted PY - 2015/6/19/aheadofprint PY - 2015/6/4/entrez PY - 2015/6/4/pubmed PY - 2016/4/15/medline SP - 287 EP - 96 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 117 IS - 5 N2 - Neurodegenerative diseases are the diseases of the central nervous system with various aetiology and symptoms. Dementia, Alzheimer's disease (AD), Parkinson's disease (PD) and autism are some examples of neurodegenerative diseases. Hyperhomocysteinemia (Hhcy) is considered to be an independent risk factor for numerous pathological conditions under neurodegenerative diseases. Along with genetic factors that are the prime cause of homocysteine (Hcy) imbalance, the nutritional and hormonal factors are also contributing to high Hcy levels in the body. Numerous clinical and epidemiological data confirm the direct correlation of Hcy levels in the body and generation of different types of central nervous system disorders, cardiovascular diseases, cancer and others. Till now, it is difficult to say whether homocysteine is the cause of the disease or whether it is one of the impacts of the diseases. However, Hhcy is a surrogate marker of vitamin B deficiency and is a neurotoxic agent. This Mini Review will give an overview of how far research has gone into understanding the homocysteine imbalance with prognostic, causative and preventive measures in treating neurodegenerative diseases. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/26036286/full_citation L2 - http://dx.doi.org/10.1111/bcpt.12424 ER -