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Season is an unreliable predictor of Lyme neuroborreliosis.
Dan Med J. 2015 Jun; 62(6)DM

Abstract

INTRODUCTION

Lyme neuroborreliosis (LNB) is a tick-borne infection of the nervous system caused by the spirochete Borrelia burgdorferi sensu lato. The primary symptoms are usually painful radiculitis, facial palsy and lymphocytic meningitis. The aim of this study was to provide data on the seasonal variation, anamnesis, symptoms, laboratory data and course of the disease in adults (≥ 16 years).

METHODS

The medical records of 69 patients with confirmed LNB who attended the Department of Neurology, Lillebaelt Hospital, Vejle, Denmark, were analysed. The diagnosis was confirmed by the presence of leucocytosis in the cerebrospinal fluid and intrathecal production of immunoglobulin M and/or G anti-B. burgdorferi antibodies.

RESULTS

Onset of neurological symptoms in LNB occurred year round in the Region of Southern Denmark. Only half of the patients had a history of a tick bite or erythema migrans (EM). Half of the patients who observed a tick bite subsequently reported EM. The duration from the onset of neurological symptoms to referral to hospital was remarkably long for patients with radiculoneuritis, whereas the onset of facial palsy led to a swift referral. Patients who were ≥ 50 years old had a significantly lower age-related risk of facial palsy without radicular symptoms.

CONCLUSION

In this study, winter as a low-risk season was not a reliable factor in ruling out LNB. This finding may be relevant when investigating the cause of facial palsy and radicular symptoms.

Authors+Show Affiliations

Neurologisk Afdeling, Vejle Sygehus, Kabbeltoft 25, 7100 Vejle, Denmark. ole.vilholm@rsyd.dk.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26036883

Citation

Petersen, Bo Bødker, et al. "Season Is an Unreliable Predictor of Lyme Neuroborreliosis." Danish Medical Journal, vol. 62, no. 6, 2015.
Petersen BB, Møller JK, Vilholm OJ. Season is an unreliable predictor of Lyme neuroborreliosis. Dan Med J. 2015;62(6).
Petersen, B. B., Møller, J. K., & Vilholm, O. J. (2015). Season is an unreliable predictor of Lyme neuroborreliosis. Danish Medical Journal, 62(6).
Petersen BB, Møller JK, Vilholm OJ. Season Is an Unreliable Predictor of Lyme Neuroborreliosis. Dan Med J. 2015;62(6) PubMed PMID: 26036883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Season is an unreliable predictor of Lyme neuroborreliosis. AU - Petersen,Bo Bødker, AU - Møller,Jens Kjølseth, AU - Vilholm,Ole Jakob, PY - 2015/6/4/entrez PY - 2015/6/4/pubmed PY - 2016/2/22/medline JF - Danish medical journal JO - Dan Med J VL - 62 IS - 6 N2 - INTRODUCTION: Lyme neuroborreliosis (LNB) is a tick-borne infection of the nervous system caused by the spirochete Borrelia burgdorferi sensu lato. The primary symptoms are usually painful radiculitis, facial palsy and lymphocytic meningitis. The aim of this study was to provide data on the seasonal variation, anamnesis, symptoms, laboratory data and course of the disease in adults (≥ 16 years). METHODS: The medical records of 69 patients with confirmed LNB who attended the Department of Neurology, Lillebaelt Hospital, Vejle, Denmark, were analysed. The diagnosis was confirmed by the presence of leucocytosis in the cerebrospinal fluid and intrathecal production of immunoglobulin M and/or G anti-B. burgdorferi antibodies. RESULTS: Onset of neurological symptoms in LNB occurred year round in the Region of Southern Denmark. Only half of the patients had a history of a tick bite or erythema migrans (EM). Half of the patients who observed a tick bite subsequently reported EM. The duration from the onset of neurological symptoms to referral to hospital was remarkably long for patients with radiculoneuritis, whereas the onset of facial palsy led to a swift referral. Patients who were ≥ 50 years old had a significantly lower age-related risk of facial palsy without radicular symptoms. CONCLUSION: In this study, winter as a low-risk season was not a reliable factor in ruling out LNB. This finding may be relevant when investigating the cause of facial palsy and radicular symptoms. SN - 2245-1919 UR - https://www.unboundmedicine.com/medline/citation/26036883/Season_is_an_unreliable_predictor_of_Lyme_neuroborreliosis_ L2 - http://ugeskriftet.dk/dmj/A5084 DB - PRIME DP - Unbound Medicine ER -