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Cardiovascular risk in chronic kidney disease patients: intima-media thickness predicts the incidence and severity of histologically assessed medial calcification in radial arteries.
BMC Nephrol 2015; 16:78BN

Abstract

BACKGROUND

The objective of the study was to determine the relationship between common carotid artery intima-media thickness (CCA-IMT) and histologically assessed calcification of radial artery in relation to clinical features and laboratory markers of bone and mineral metabolism, inflammation, and oxidative stress in patients with stage 5 chronic kidney disease (CKD).

METHODS

The study comprised 59 patients (36 hemodialyzed, 23 predialysis). CCA-IMT was measured by ultrasonography; the biochemical parameters examined were assessed using routine laboratory methods, ELISA micro-plate immunoassays and spectrophotometry. Fragments of radial artery obtained during creation of hemodialysis access were cryosectioned and stained for calcifications using von Kossa method and alizarin red.

RESULTS

Glucose, osteoprotegerin, pentraxin 3 and Framingham risk score significantly correlated with CCA-IMT. In multiple regression analysis, OPG positively predicted CCA-IMT. Radial artery calcifications were found in 34 patients who showed higher CCA-IMT (0.98 ± 0.13 vs 0.86 ± 0.14 mm; P = 0.006). Higher CCA-IMT values were also associated with more advanced calcifications. CCA-IMT and the presence of plaques in common carotid artery were positive predictors of radial artery calcifications, independent of dialysis status, Framingham risk score, CRP and Ca x Pi [OR for calcifications 2.19 (1.08-4.45) per 0.1 mm increase in CCA-IMT]. The presence of radial artery calcifications was a significant predictor of mortality, independent of dialysis status and Framingham risk score [HR 3.16 (1.03-9.64)].

CONCLUSIONS

In CKD patients, CCA-IMT examination can be used as a surrogate measure to assess the incidence and severity of arterial medial calcification which is associated with poor clinical outcome in these patients.

Authors+Show Affiliations

Chair and Department of Nephrology, Jagiellonian University, Medical College, Kopernika 15c, 31-501, Cracow, Poland. kasiajanda@op.pl.Chair and Department of Nephrology, Jagiellonian University, Medical College, Kopernika 15c, 31-501, Cracow, Poland. mkrzanowski@op.pl.Chair and Department of Histology, Jagiellonian University, Medical College, Cracow, Poland. mmgajda@cyf-kr.edu.pl.Department of Medical Diagnostics, Jagiellonian University, Medical College, Cracow, Poland. paulina.dumnicka@uj.edu.pl.Chair of Clinical Biochemistry, Jagiellonian University, Medical College, Cracow, Poland. danuta.fedak@uj.edu.pl.Chair and Department of Histology, Jagiellonian University, Medical College, Cracow, Poland. mmlis@cyf-kr.edu.pl.Chair and Department of Nephrology, Jagiellonian University, Medical College, Kopernika 15c, 31-501, Cracow, Poland. jaskowskip@interia.pl.Radioligand Laboratory, Faculty of Pharmacy, Jagiellonian University, Medical College, Cracow, Poland. apietrzy1@cm-uj.krakow.pl.Chair and Department of Histology, Jagiellonian University, Medical College, Cracow, Poland. mmlitwin@cyf-kr.edu.pl.Chair and Department of Nephrology, Jagiellonian University, Medical College, Kopernika 15c, 31-501, Cracow, Poland. wladsul@mp.pl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26037625

Citation

Janda, Katarzyna, et al. "Cardiovascular Risk in Chronic Kidney Disease Patients: Intima-media Thickness Predicts the Incidence and Severity of Histologically Assessed Medial Calcification in Radial Arteries." BMC Nephrology, vol. 16, 2015, p. 78.
Janda K, Krzanowski M, Gajda M, et al. Cardiovascular risk in chronic kidney disease patients: intima-media thickness predicts the incidence and severity of histologically assessed medial calcification in radial arteries. BMC Nephrol. 2015;16:78.
Janda, K., Krzanowski, M., Gajda, M., Dumnicka, P., Fedak, D., Lis, G. J., ... Sułowicz, W. (2015). Cardiovascular risk in chronic kidney disease patients: intima-media thickness predicts the incidence and severity of histologically assessed medial calcification in radial arteries. BMC Nephrology, 16, p. 78. doi:10.1186/s12882-015-0067-8.
Janda K, et al. Cardiovascular Risk in Chronic Kidney Disease Patients: Intima-media Thickness Predicts the Incidence and Severity of Histologically Assessed Medial Calcification in Radial Arteries. BMC Nephrol. 2015 Jun 3;16:78. PubMed PMID: 26037625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk in chronic kidney disease patients: intima-media thickness predicts the incidence and severity of histologically assessed medial calcification in radial arteries. AU - Janda,Katarzyna, AU - Krzanowski,Marcin, AU - Gajda,Mariusz, AU - Dumnicka,Paulina, AU - Fedak,Danuta, AU - Lis,Grzegorz J, AU - Jaśkowski,Piotr, AU - Pietrzycka,Agata, AU - Litwin,Jan A, AU - Sułowicz,Władysław, Y1 - 2015/06/03/ PY - 2015/01/24/received PY - 2015/05/20/accepted PY - 2015/6/4/entrez PY - 2015/6/4/pubmed PY - 2016/1/27/medline SP - 78 EP - 78 JF - BMC nephrology JO - BMC Nephrol VL - 16 N2 - BACKGROUND: The objective of the study was to determine the relationship between common carotid artery intima-media thickness (CCA-IMT) and histologically assessed calcification of radial artery in relation to clinical features and laboratory markers of bone and mineral metabolism, inflammation, and oxidative stress in patients with stage 5 chronic kidney disease (CKD). METHODS: The study comprised 59 patients (36 hemodialyzed, 23 predialysis). CCA-IMT was measured by ultrasonography; the biochemical parameters examined were assessed using routine laboratory methods, ELISA micro-plate immunoassays and spectrophotometry. Fragments of radial artery obtained during creation of hemodialysis access were cryosectioned and stained for calcifications using von Kossa method and alizarin red. RESULTS: Glucose, osteoprotegerin, pentraxin 3 and Framingham risk score significantly correlated with CCA-IMT. In multiple regression analysis, OPG positively predicted CCA-IMT. Radial artery calcifications were found in 34 patients who showed higher CCA-IMT (0.98 ± 0.13 vs 0.86 ± 0.14 mm; P = 0.006). Higher CCA-IMT values were also associated with more advanced calcifications. CCA-IMT and the presence of plaques in common carotid artery were positive predictors of radial artery calcifications, independent of dialysis status, Framingham risk score, CRP and Ca x Pi [OR for calcifications 2.19 (1.08-4.45) per 0.1 mm increase in CCA-IMT]. The presence of radial artery calcifications was a significant predictor of mortality, independent of dialysis status and Framingham risk score [HR 3.16 (1.03-9.64)]. CONCLUSIONS: In CKD patients, CCA-IMT examination can be used as a surrogate measure to assess the incidence and severity of arterial medial calcification which is associated with poor clinical outcome in these patients. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/26037625/Cardiovascular_risk_in_chronic_kidney_disease_patients:_intima_media_thickness_predicts_the_incidence_and_severity_of_histologically_assessed_medial_calcification_in_radial_arteries_ L2 - https://www.biomedcentral.com/1471-2369/16/78 DB - PRIME DP - Unbound Medicine ER -