TY - JOUR T1 - Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5. AU - Woo,Patrick Cy, AU - Lau,Susanna Kp, AU - Li,Kenneth Sm, AU - Tsang,Alan Kl, AU - Yuen,Kwok-Yung, Y1 - 2012/11/07/ PY - 2012/10/06/received PY - 2012/10/09/revised PY - 2012/10/09/accepted PY - 2015/6/4/entrez PY - 2012/11/1/pubmed PY - 2012/11/1/medline SP - e35 EP - e35 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 1 IS - 11 N2 - The recent outbreak of severe respiratory infections associated with a novel group C betacoronavirus (HCoV-EMC) from Saudi Arabia has drawn global attention to another highly probable "SARS-like" animal-to-human interspecies jumping event in coronavirus (CoV). The genome of HCoV-EMC is most closely related to Tylonycteris bat coronavirus HKU4 (Ty-BatCoV HKU4) and Pipistrellus bat coronavirus HKU5 (Pi-BatCoV HKU5) we discovered in 2006. Phylogenetically, HCoV-EMC is clustered with Ty-BatCoV HKU4/Pi-BatCoV HKU5 with high bootstrap supports, indicating that HCoV-EMC is a group C betaCoV. The major difference between HCoV-EMC and Ty-BatCoV HKU4/Pi-BatCoV HKU5 is in the region between S and E, where HCoV-EMC possesses five ORFs (NS3a-NS3e) instead of four, with low (31%-62%) amino acid identities to Ty-BatCoV HKU4/Pi-BatCoV HKU5. Comparison of the seven conserved replicase domains for species demarcation shows that HCoV-EMC is a novel CoV species. More intensive surveillance studies in bats and other animals may reveal the natural host of HCoV-EMC. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/26038405/Genetic_relatedness_of_the_novel_human_group_C_betacoronavirus_to_Tylonycteris_bat_coronavirus_HKU4_and_Pipistrellus_bat_coronavirus_HKU5_ DB - PRIME DP - Unbound Medicine ER -