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Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS.
Bioanalysis. 2015; 7(9):1119-36.B

Abstract

BACKGROUND

New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as 'bath salts' or 'research chemicals' and comprehensive bioanalytical methods are needed for their detection.

METHODOLOGY

We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min.

CONCLUSION

A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs.

Authors+Show Affiliations

1Institute of Forensic Medicine, University of Bern, Bern, Switzerland.1Institute of Forensic Medicine, University of Bern, Bern, Switzerland.1Institute of Forensic Medicine, University of Bern, Bern, Switzerland.2Institute of Forensic Medicine, Medical Center, University of Freiburg, Freiburg, Germany.No affiliation info available1Institute of Forensic Medicine, University of Bern, Bern, Switzerland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26039809

Citation

Ambach, Lars, et al. "Detection and Quantification of 56 New Psychoactive Substances in Whole Blood and Urine By LC-MS/MS." Bioanalysis, vol. 7, no. 9, 2015, pp. 1119-36.
Ambach L, Redondo AH, König S, et al. Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS. Bioanalysis. 2015;7(9):1119-36.
Ambach, L., Redondo, A. H., König, S., Angerer, V., Schürch, S., & Weinmann, W. (2015). Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS. Bioanalysis, 7(9), 1119-36. https://doi.org/10.4155/bio.15.48
Ambach L, et al. Detection and Quantification of 56 New Psychoactive Substances in Whole Blood and Urine By LC-MS/MS. Bioanalysis. 2015;7(9):1119-36. PubMed PMID: 26039809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC-MS/MS. AU - Ambach,Lars, AU - Redondo,Ana Hernández, AU - König,Stefan, AU - Angerer,Verena, AU - Schürch,Stefan, AU - Weinmann,Wolfgang, PY - 2015/6/4/entrez PY - 2015/6/4/pubmed PY - 2016/2/26/medline SP - 1119 EP - 36 JF - Bioanalysis JO - Bioanalysis VL - 7 IS - 9 N2 - BACKGROUND: New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as 'bath salts' or 'research chemicals' and comprehensive bioanalytical methods are needed for their detection. METHODOLOGY: We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min. CONCLUSION: A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs. SN - 1757-6199 UR - https://www.unboundmedicine.com/medline/citation/26039809/Detection_and_quantification_of_56_new_psychoactive_substances_in_whole_blood_and_urine_by_LC_MS/MS_ L2 - https://www.future-science.com/doi/10.4155/bio.15.48?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -