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Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes.
Digestion 2015; 92(1):1-7D

Abstract

BACKGROUND

The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes.

AIM

To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders.

METHODS

Prepubertal children of ages 3-12 with either lactose intolerance (LI) (n = 38, age 8.61 ± 3.08, male/female 19/19), or celiac disease (CD) (n = 24) were compared to healthy controls (n = 49, age 7.95 ± 2.64, male/female 28/21). A separate cohort of combined prepubertal and pubertal subjects with inflammatory bowel disease (IBD) (n = 59, age 16.4 ± 2.2, male/female 31/27) were also compared to healthy controls (n = 116, male/female 49/67, age 14.6 ± 4.4). Vitamin D deficiency was defined as 25(OH)D of <50 nmol/l, overweight as body mass index (BMI) of ≥ 85th but <95th percentile, and obesity as BMI ≥ 95th percentile.

RESULTS

Among the controls, 25(OH)D was significantly higher in the normal-weight prepubertal controls vs. the overweight/obese controls (p = 0.001), and similarly so for the combined cohort of prepubertal and pubertal controls (p = 0.031). In contrast, there was no significant difference in 25(OH)D concentration between the normal-weight vs. overweight/obese patients with LI (p = 0.335), CD (p = 0.387), and IBD (p = 0.883).

CONCLUSION

There is no association between adiposity and serum 25(OH)D in pediatric malabsorption syndromes.

Authors+Show Affiliations

Department of Pediatrics, University of Massachusetts Medical School, Worcester, Mass., USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26043850

Citation

Nwosu, Benjamin Udoka, and Louise Maranda. "Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes." Digestion, vol. 92, no. 1, 2015, pp. 1-7.
Nwosu BU, Maranda L. Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes. Digestion. 2015;92(1):1-7.
Nwosu, B. U., & Maranda, L. (2015). Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes. Digestion, 92(1), pp. 1-7. doi:10.1159/000381895.
Nwosu BU, Maranda L. Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes. Digestion. 2015;92(1):1-7. PubMed PMID: 26043850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes. AU - Nwosu,Benjamin Udoka, AU - Maranda,Louise, Y1 - 2015/05/30/ PY - 2015/01/05/received PY - 2015/03/25/accepted PY - 2015/6/6/entrez PY - 2015/6/6/pubmed PY - 2016/4/20/medline SP - 1 EP - 7 JF - Digestion JO - Digestion VL - 92 IS - 1 N2 - BACKGROUND: The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM: To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS: Prepubertal children of ages 3-12 with either lactose intolerance (LI) (n = 38, age 8.61 ± 3.08, male/female 19/19), or celiac disease (CD) (n = 24) were compared to healthy controls (n = 49, age 7.95 ± 2.64, male/female 28/21). A separate cohort of combined prepubertal and pubertal subjects with inflammatory bowel disease (IBD) (n = 59, age 16.4 ± 2.2, male/female 31/27) were also compared to healthy controls (n = 116, male/female 49/67, age 14.6 ± 4.4). Vitamin D deficiency was defined as 25(OH)D of <50 nmol/l, overweight as body mass index (BMI) of ≥ 85th but <95th percentile, and obesity as BMI ≥ 95th percentile. RESULTS: Among the controls, 25(OH)D was significantly higher in the normal-weight prepubertal controls vs. the overweight/obese controls (p = 0.001), and similarly so for the combined cohort of prepubertal and pubertal controls (p = 0.031). In contrast, there was no significant difference in 25(OH)D concentration between the normal-weight vs. overweight/obese patients with LI (p = 0.335), CD (p = 0.387), and IBD (p = 0.883). CONCLUSION: There is no association between adiposity and serum 25(OH)D in pediatric malabsorption syndromes. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/26043850/Vitamin_D_Status_and_Adiposity_in_Pediatric_Malabsorption_Syndromes_ L2 - https://www.karger.com?DOI=10.1159/000381895 DB - PRIME DP - Unbound Medicine ER -