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Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients.
PLoS One 2015; 10(6):e0129080Plos

Abstract

INTRODUCTION

31-77% of patients with COPD have vitamin D deficiency and insufficiency, with results being highly variable between studies. Vitamin D may also correlate with disease characteristics.

AIM

To find out the prevalence of vitamin D deficiency and insufficiency in patients with COPD admitted for exacerbation and a risk factors for lower vitamin D levels among comorbidities and COPD characteristics.

METHODS

152 patients were studied for vitamin D serum levels (25(OH)D). All of them were also assessed for diabetes mellitus (DM) and metabolic syndrome (MS). Data were gathered also for smoking status and exacerbations in last year. All patients completed CAT and mMRC questionnaires and underwent spirometry.

RESULTS

A total of 83,6% of patients have reduced levels of vitamin D. 42,8% (65/152) have vitamin D insufficiency (defined as 25-50 nmol/L) and 40,8% (62/152) have vitamin D deficiency (<25 nmol/L). The mean level of 25(OH)D for all patients is 31,97 nmol/L (95%CI 29,12-34,68). Vitamin D deficiency and insufficiency are more prevalent in females vs. males (97,7 vs 77,8%; p = 0.003). The prevalence and severity of vitamin D deficiency and insufficiency in this study is significantly higher when compared to an unselected Bulgarian population (prevalence 75,8%; mean level 38,75 nmol/L). Vitamin D levels correlate with quality of life (measured by the mMRC scale) and lung function (FVC, FEV1, FEV6, FEF2575, FEV3, but not with FEV1/FVC ratio and PEF), it does not correlate with the presence of arterial hypertension, DM, MS and number of moderate, severe and total exacerbations. Vitamin D deficiency is a risk factor for longer hospital stay.

CONCLUSIONS

The patients with COPD admitted for exacerbation are a risk group for vitamin D deficiency and insufficiency, which is associated with worse disease characteristics.

Authors+Show Affiliations

Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.Central Clinical Laboratory, UMHAT 'Alexandrovska', Sofia, Bulgaria.Central Clinical Laboratory, UMHAT 'Alexandrovska', Sofia, Bulgaria.Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.Clinical Center for Pulmonary Diseases, SHATPD 'Sveta Sofia', Sofia, Bulgaria.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26047485

Citation

Mekov, Evgeni, et al. "Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients." PloS One, vol. 10, no. 6, 2015, pp. e0129080.
Mekov E, Slavova Y, Tsakova A, et al. Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. PLoS ONE. 2015;10(6):e0129080.
Mekov, E., Slavova, Y., Tsakova, A., Genova, M., Kostadinov, D., Minchev, D., ... Tafradjiiska, M. (2015). Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. PloS One, 10(6), pp. e0129080. doi:10.1371/journal.pone.0129080.
Mekov E, et al. Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. PLoS ONE. 2015;10(6):e0129080. PubMed PMID: 26047485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Deficiency and Insufficiency in Hospitalized COPD Patients. AU - Mekov,Evgeni, AU - Slavova,Yanina, AU - Tsakova,Adelina, AU - Genova,Marianka, AU - Kostadinov,Dimitar, AU - Minchev,Delcho, AU - Marinova,Dora, AU - Tafradjiiska,Maya, Y1 - 2015/06/05/ PY - 2015/02/04/received PY - 2015/05/04/accepted PY - 2015/6/6/entrez PY - 2015/6/6/pubmed PY - 2016/3/26/medline SP - e0129080 EP - e0129080 JF - PloS one JO - PLoS ONE VL - 10 IS - 6 N2 - INTRODUCTION: 31-77% of patients with COPD have vitamin D deficiency and insufficiency, with results being highly variable between studies. Vitamin D may also correlate with disease characteristics. AIM: To find out the prevalence of vitamin D deficiency and insufficiency in patients with COPD admitted for exacerbation and a risk factors for lower vitamin D levels among comorbidities and COPD characteristics. METHODS: 152 patients were studied for vitamin D serum levels (25(OH)D). All of them were also assessed for diabetes mellitus (DM) and metabolic syndrome (MS). Data were gathered also for smoking status and exacerbations in last year. All patients completed CAT and mMRC questionnaires and underwent spirometry. RESULTS: A total of 83,6% of patients have reduced levels of vitamin D. 42,8% (65/152) have vitamin D insufficiency (defined as 25-50 nmol/L) and 40,8% (62/152) have vitamin D deficiency (<25 nmol/L). The mean level of 25(OH)D for all patients is 31,97 nmol/L (95%CI 29,12-34,68). Vitamin D deficiency and insufficiency are more prevalent in females vs. males (97,7 vs 77,8%; p = 0.003). The prevalence and severity of vitamin D deficiency and insufficiency in this study is significantly higher when compared to an unselected Bulgarian population (prevalence 75,8%; mean level 38,75 nmol/L). Vitamin D levels correlate with quality of life (measured by the mMRC scale) and lung function (FVC, FEV1, FEV6, FEF2575, FEV3, but not with FEV1/FVC ratio and PEF), it does not correlate with the presence of arterial hypertension, DM, MS and number of moderate, severe and total exacerbations. Vitamin D deficiency is a risk factor for longer hospital stay. CONCLUSIONS: The patients with COPD admitted for exacerbation are a risk group for vitamin D deficiency and insufficiency, which is associated with worse disease characteristics. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26047485/Vitamin_D_Deficiency_and_Insufficiency_in_Hospitalized_COPD_Patients_ L2 - http://dx.plos.org/10.1371/journal.pone.0129080 DB - PRIME DP - Unbound Medicine ER -