Tags

Type your tag names separated by a space and hit enter

A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals.
Lipids Health Dis 2015; 14:53LH

Abstract

Circulating levels of triacylglycerol (TG) is a recognized risk factor for developing cardiovascular disease, a leading cause of death worldwide. The Institute of Medicine and the American Heart Association both recommend the consumption of n-3 polyunsaturated fatty acids (PUFA), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), to reduce serum TG in hyperlipidemic individuals. Additionally, a number of systematic reviews have shown that individuals with any degree of dyslipidemia, elevated serum TG and/or cholesterol, may benefit from a 20-30% reduction in serum TG after consuming n-3 PUFA derived from marine sources. Given that individuals with serum lipid levels ranging from healthy to borderline dyslipidemic constitute a large portion of the population, the focus of this review was to assess the potential for n-3 PUFA consumption to reduce serum TG in such individuals. A total of 1341 studies were retrieved and 38 clinical intervention studies, assessing 2270 individuals, were identified for inclusion in the current review. In summary, a 9-26% reduction in circulating TG was demonstrated in studies where ≥ 4 g/day of n-3 PUFA were consumed from either marine or EPA/DHA-enriched food sources, while a 4-51% reduction was found in studies where 1-5 g/day of EPA and/or DHA was consumed through supplements. Overall, this review summarizes the current evidence with regards to the beneficial effect of n-3 PUFA on circulating TG levels in normolipidemic to borderline hyperlipidemic, otherwise healthy, individuals. Thus demonstrating that n-3 PUFA may play an important role in the maintenance of cardiovascular health and disease prevention.

Authors+Show Affiliations

Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Room 342, 491 Gordon Street, Guelph, ON, N1G 2 W1, Canada. mleslie@uoguelph.ca.Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Room 342, 491 Gordon Street, Guelph, ON, N1G 2 W1, Canada. cohen@uoguelph.ca.Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Room 342, 491 Gordon Street, Guelph, ON, N1G 2 W1, Canada. dliddle@uoguelph.ca.Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Room 342, 491 Gordon Street, Guelph, ON, N1G 2 W1, Canada. lrobinso@uoguelph.ca.Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Room 342, 491 Gordon Street, Guelph, ON, N1G 2 W1, Canada. davidma@uoguelph.ca.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26048287

Citation

Leslie, Michael A., et al. "A Review of the Effect of Omega-3 Polyunsaturated Fatty Acids On Blood Triacylglycerol Levels in Normolipidemic and Borderline Hyperlipidemic Individuals." Lipids in Health and Disease, vol. 14, 2015, p. 53.
Leslie MA, Cohen DJ, Liddle DM, et al. A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. Lipids Health Dis. 2015;14:53.
Leslie, M. A., Cohen, D. J., Liddle, D. M., Robinson, L. E., & Ma, D. W. (2015). A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. Lipids in Health and Disease, 14, p. 53. doi:10.1186/s12944-015-0049-7.
Leslie MA, et al. A Review of the Effect of Omega-3 Polyunsaturated Fatty Acids On Blood Triacylglycerol Levels in Normolipidemic and Borderline Hyperlipidemic Individuals. Lipids Health Dis. 2015 Jun 6;14:53. PubMed PMID: 26048287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. AU - Leslie,Michael A, AU - Cohen,Daniel J A, AU - Liddle,Danyelle M, AU - Robinson,Lindsay E, AU - Ma,David W L, Y1 - 2015/06/06/ PY - 2015/02/17/received PY - 2015/05/19/accepted PY - 2015/6/7/entrez PY - 2015/6/7/pubmed PY - 2016/3/29/medline SP - 53 EP - 53 JF - Lipids in health and disease JO - Lipids Health Dis VL - 14 N2 - Circulating levels of triacylglycerol (TG) is a recognized risk factor for developing cardiovascular disease, a leading cause of death worldwide. The Institute of Medicine and the American Heart Association both recommend the consumption of n-3 polyunsaturated fatty acids (PUFA), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), to reduce serum TG in hyperlipidemic individuals. Additionally, a number of systematic reviews have shown that individuals with any degree of dyslipidemia, elevated serum TG and/or cholesterol, may benefit from a 20-30% reduction in serum TG after consuming n-3 PUFA derived from marine sources. Given that individuals with serum lipid levels ranging from healthy to borderline dyslipidemic constitute a large portion of the population, the focus of this review was to assess the potential for n-3 PUFA consumption to reduce serum TG in such individuals. A total of 1341 studies were retrieved and 38 clinical intervention studies, assessing 2270 individuals, were identified for inclusion in the current review. In summary, a 9-26% reduction in circulating TG was demonstrated in studies where ≥ 4 g/day of n-3 PUFA were consumed from either marine or EPA/DHA-enriched food sources, while a 4-51% reduction was found in studies where 1-5 g/day of EPA and/or DHA was consumed through supplements. Overall, this review summarizes the current evidence with regards to the beneficial effect of n-3 PUFA on circulating TG levels in normolipidemic to borderline hyperlipidemic, otherwise healthy, individuals. Thus demonstrating that n-3 PUFA may play an important role in the maintenance of cardiovascular health and disease prevention. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/26048287/full_citation L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-015-0049-7 DB - PRIME DP - Unbound Medicine ER -