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Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
Steroids. 2015 Sep; 101:37-42.S

Abstract

A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals. The present study aimed to examine the antidepressant-like effect and the possible mechanisms of resveratrol, a naturally occurring polyphenol of phytoalexin family, on depressive-like behavior induced by repeated corticosterone injections in mice. Mice were injected subcutaneously (s.c.) with 40mg/kg corticosterone (CORT) chronically for 21days. Resveratrol and fluoxetine were administered 30min prior to the CORT injection. After 21-days treatment with respective drugs, behavioral and biochemical parameters were estimated. Since brain derived neurotrophic factor (BDNF) has been implicated in antidepressant activity of many drugs, we also evaluated the effect of resveratrol on BDNF in the hippocampus. Three weeks of CORT injections in mice resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test and tail suspension test. Further, there was a significant increase in serum corticosterone level and a significant decrease in hippocampus BDNF level in CORT-treated mice. Treatment of mice with resveratrol significantly ameliorated all the behavioral and biochemical changes induced by corticosterone. These results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels.

Authors+Show Affiliations

Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India. Electronic address: ishreddy4@gmail.com.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India; Department of Pharmacology, Gauhati Medical College, Bhangagarh, Guwahati 781032, Assam, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26048446

Citation

Ali, Syed Hamid, et al. "Resveratrol Ameliorates Depressive-like Behavior in Repeated Corticosterone-induced Depression in Mice." Steroids, vol. 101, 2015, pp. 37-42.
Ali SH, Madhana RM, K V A, et al. Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. Steroids. 2015;101:37-42.
Ali, S. H., Madhana, R. M., K V, A., Kasala, E. R., Bodduluru, L. N., Pitta, S., Mahareddy, J. R., & Lahkar, M. (2015). Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. Steroids, 101, 37-42. https://doi.org/10.1016/j.steroids.2015.05.010
Ali SH, et al. Resveratrol Ameliorates Depressive-like Behavior in Repeated Corticosterone-induced Depression in Mice. Steroids. 2015;101:37-42. PubMed PMID: 26048446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. AU - Ali,Syed Hamid, AU - Madhana,Rajaram Mohanrao, AU - K V,Athira, AU - Kasala,Eshvendar Reddy, AU - Bodduluru,Lakshmi Narendra, AU - Pitta,Sathish, AU - Mahareddy,Jalandhar Reddy, AU - Lahkar,Mangala, Y1 - 2015/06/03/ PY - 2015/03/05/received PY - 2015/05/20/revised PY - 2015/05/25/accepted PY - 2015/6/7/entrez PY - 2015/6/7/pubmed PY - 2016/4/7/medline KW - BDNF KW - Corticosterone KW - Depressive-like behavior KW - HPA axis KW - Hippocampus KW - Resveratrol SP - 37 EP - 42 JF - Steroids JO - Steroids VL - 101 N2 - A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals. The present study aimed to examine the antidepressant-like effect and the possible mechanisms of resveratrol, a naturally occurring polyphenol of phytoalexin family, on depressive-like behavior induced by repeated corticosterone injections in mice. Mice were injected subcutaneously (s.c.) with 40mg/kg corticosterone (CORT) chronically for 21days. Resveratrol and fluoxetine were administered 30min prior to the CORT injection. After 21-days treatment with respective drugs, behavioral and biochemical parameters were estimated. Since brain derived neurotrophic factor (BDNF) has been implicated in antidepressant activity of many drugs, we also evaluated the effect of resveratrol on BDNF in the hippocampus. Three weeks of CORT injections in mice resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test and tail suspension test. Further, there was a significant increase in serum corticosterone level and a significant decrease in hippocampus BDNF level in CORT-treated mice. Treatment of mice with resveratrol significantly ameliorated all the behavioral and biochemical changes induced by corticosterone. These results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/26048446/Resveratrol_ameliorates_depressive_like_behavior_in_repeated_corticosterone_induced_depression_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(15)00167-1 DB - PRIME DP - Unbound Medicine ER -