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The gut microbiota and Type 1 Diabetes.
Clin Immunol. 2015 Aug; 159(2):143-53.CI

Abstract

Type 1 Diabetes (T1D) is a multifactorial, immune-mediated disease, which is characterized by the progressive destruction of autologous insulin-producing beta cells in the pancreas. The risk of developing T1D is determined by genetic, epigenetic and environmental factors. In the past few decades there has been a continuous rise in the incidence of T1D, which cannot be explained by genetic factors alone. Changes in our lifestyle that include diet, hygiene, and antibiotic usage have already been suggested to be causal factors for this rising T1D incidence. Only recently have microbiota, which are affected by all these factors, been recognized as key environmental factors affecting T1D development. In this review we will summarize current knowledge on the impact of gut microbiota on T1D development and give an outlook on the potential to design new microbiota-based therapies in the prevention and treatment of T1D.

Authors+Show Affiliations

Section of Endocrinology, Yale University School of Medicine, New Haven, CT, USA.Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK.Section of Endocrinology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: li.wen@yale.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26051037

Citation

Gülden, Elke, et al. "The Gut Microbiota and Type 1 Diabetes." Clinical Immunology (Orlando, Fla.), vol. 159, no. 2, 2015, pp. 143-53.
Gülden E, Wong FS, Wen L. The gut microbiota and Type 1 Diabetes. Clin Immunol. 2015;159(2):143-53.
Gülden, E., Wong, F. S., & Wen, L. (2015). The gut microbiota and Type 1 Diabetes. Clinical Immunology (Orlando, Fla.), 159(2), 143-53. https://doi.org/10.1016/j.clim.2015.05.013
Gülden E, Wong FS, Wen L. The Gut Microbiota and Type 1 Diabetes. Clin Immunol. 2015;159(2):143-53. PubMed PMID: 26051037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The gut microbiota and Type 1 Diabetes. AU - Gülden,Elke, AU - Wong,F Susan, AU - Wen,Li, Y1 - 2015/06/04/ PY - 2015/02/04/received PY - 2015/05/18/revised PY - 2015/05/19/accepted PY - 2015/6/9/entrez PY - 2015/6/9/pubmed PY - 2015/12/15/medline KW - Gut microbiota KW - Gut permeability KW - Th17 cells KW - Treg KW - Type 1 Diabetes SP - 143 EP - 53 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 159 IS - 2 N2 - Type 1 Diabetes (T1D) is a multifactorial, immune-mediated disease, which is characterized by the progressive destruction of autologous insulin-producing beta cells in the pancreas. The risk of developing T1D is determined by genetic, epigenetic and environmental factors. In the past few decades there has been a continuous rise in the incidence of T1D, which cannot be explained by genetic factors alone. Changes in our lifestyle that include diet, hygiene, and antibiotic usage have already been suggested to be causal factors for this rising T1D incidence. Only recently have microbiota, which are affected by all these factors, been recognized as key environmental factors affecting T1D development. In this review we will summarize current knowledge on the impact of gut microbiota on T1D development and give an outlook on the potential to design new microbiota-based therapies in the prevention and treatment of T1D. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/26051037/The_gut_microbiota_and_Type_1_Diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(15)00198-9 DB - PRIME DP - Unbound Medicine ER -