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The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging.
Cell Immunol. 2015 Aug; 296(2):149-54.CI

Abstract

Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets.

Authors+Show Affiliations

Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Health School, University of Vale do Rio dos Sinos (UNISINOS), Sao Leopoldo, Brazil. Electronic address: gceruttim@unisinos.br.Institute of Geriatrics and Gerontology (IGG), PUCRS, Porto Alegre, Brazil.Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.Institute of Geriatrics and Gerontology (IGG), PUCRS, Porto Alegre, Brazil.Health Sciences Center, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26051633

Citation

Muller, Guilherme Cerutti, et al. "The Inverted CD4:CD8 Ratio Is Associated With Gender-related Changes in Oxidative Stress During Aging." Cellular Immunology, vol. 296, no. 2, 2015, pp. 149-54.
Muller GC, Gottlieb MG, Luz Correa B, et al. The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging. Cell Immunol. 2015;296(2):149-54.
Muller, G. C., Gottlieb, M. G., Luz Correa, B., Gomes Filho, I., Moresco, R. N., & Bauer, M. E. (2015). The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging. Cellular Immunology, 296(2), 149-54. https://doi.org/10.1016/j.cellimm.2015.05.006
Muller GC, et al. The Inverted CD4:CD8 Ratio Is Associated With Gender-related Changes in Oxidative Stress During Aging. Cell Immunol. 2015;296(2):149-54. PubMed PMID: 26051633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging. AU - Muller,Guilherme Cerutti, AU - Gottlieb,Maria Gabriela Valle, AU - Luz Correa,Bruna, AU - Gomes Filho,Irênio, AU - Moresco,Rafael Noal, AU - Bauer,Moisés Evandro, Y1 - 2015/05/28/ PY - 2015/01/22/received PY - 2015/05/22/revised PY - 2015/05/25/accepted PY - 2015/6/9/entrez PY - 2015/6/9/pubmed PY - 2015/10/1/medline KW - Antioxidant power KW - Cytomegalovirus KW - Immune risk profile KW - Immunosenescence KW - Inflammation KW - Oxidative stress SP - 149 EP - 54 JF - Cellular immunology JO - Cell Immunol VL - 296 IS - 2 N2 - Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets. SN - 1090-2163 UR - https://www.unboundmedicine.com/medline/citation/26051633/The_inverted_CD4:CD8_ratio_is_associated_with_gender_related_changes_in_oxidative_stress_during_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(15)00109-4 DB - PRIME DP - Unbound Medicine ER -