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Thalassemia and risk of dementia: a nationwide population-based retrospective cohort study.
Eur J Intern Med. 2015 Sep; 26(7):554-9.EJ

Abstract

BACKGROUND

This study is a nationwide population-based retrospective cohort study to investigate the risk for developing dementia in thalassemia population.

METHODS

In a longitudinal cohort of 1 million insured people, we identified 871 thalassemia patients who were newly diagnosed between 2000 and 2004 and selected a comparison cohort of 3484 subjects without thalassemia. We analyzed the risks for thalassemia and dementia using Cox proportional hazard regression models to assess the dementia risk in thalassemia patients after adjusting for age, gender, insured amount, urbanization and comorbidities.

RESULTS

The overall risks for developing dementia were 1.88-fold (95% CI=1.10-3.21) in patients with thalassemia compared with the comparison cohort after adjusting for age, sex, insured amount, urbanization and comorbidities. The combined effects measured for patients afflicted with thalassemia and the comorbidities of diabetes, hypertension, CAD, head injury, depression, CKD, or substance-related disorder exhibited a significant association with hyperlipidemia risk compared with that measured for patients without thalassemia and without any counterpart comorbidities. In subgroup analysis, the HRs of dementia increased, from 1.69 (95% CI=0.93-3.07) for those who had not undergone transfusion to 2.72 (95% CI=1.09-6.78) for those experienced transfusion compared with the no thalassemia cohort (p for trend<0.01).

CONCLUSION

Our long-term cohort study result showed that thalassemia should be considered a crucial risk factor for developing dementia.

Authors+Show Affiliations

Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan. Electronic address: d10040@mail.cmuh.org.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26051928

Citation

Chen, Yu-Guang, et al. "Thalassemia and Risk of Dementia: a Nationwide Population-based Retrospective Cohort Study." European Journal of Internal Medicine, vol. 26, no. 7, 2015, pp. 554-9.
Chen YG, Lin TY, Chen HJ, et al. Thalassemia and risk of dementia: a nationwide population-based retrospective cohort study. Eur J Intern Med. 2015;26(7):554-9.
Chen, Y. G., Lin, T. Y., Chen, H. J., Dai, M. S., Ho, C. L., & Kao, C. H. (2015). Thalassemia and risk of dementia: a nationwide population-based retrospective cohort study. European Journal of Internal Medicine, 26(7), 554-9. https://doi.org/10.1016/j.ejim.2015.05.015
Chen YG, et al. Thalassemia and Risk of Dementia: a Nationwide Population-based Retrospective Cohort Study. Eur J Intern Med. 2015;26(7):554-9. PubMed PMID: 26051928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thalassemia and risk of dementia: a nationwide population-based retrospective cohort study. AU - Chen,Yu-Guang, AU - Lin,Te-Yu, AU - Chen,Hsuan-Ju, AU - Dai,Ming-Shen, AU - Ho,Ching-Liang, AU - Kao,Chia-Hung, Y1 - 2015/06/06/ PY - 2015/05/14/received PY - 2015/05/21/accepted PY - 2015/6/9/entrez PY - 2015/6/9/pubmed PY - 2016/6/11/medline KW - Dementia KW - Nationwide population-based study KW - Thalassemia KW - Transfusion SP - 554 EP - 9 JF - European journal of internal medicine JO - Eur J Intern Med VL - 26 IS - 7 N2 - BACKGROUND: This study is a nationwide population-based retrospective cohort study to investigate the risk for developing dementia in thalassemia population. METHODS: In a longitudinal cohort of 1 million insured people, we identified 871 thalassemia patients who were newly diagnosed between 2000 and 2004 and selected a comparison cohort of 3484 subjects without thalassemia. We analyzed the risks for thalassemia and dementia using Cox proportional hazard regression models to assess the dementia risk in thalassemia patients after adjusting for age, gender, insured amount, urbanization and comorbidities. RESULTS: The overall risks for developing dementia were 1.88-fold (95% CI=1.10-3.21) in patients with thalassemia compared with the comparison cohort after adjusting for age, sex, insured amount, urbanization and comorbidities. The combined effects measured for patients afflicted with thalassemia and the comorbidities of diabetes, hypertension, CAD, head injury, depression, CKD, or substance-related disorder exhibited a significant association with hyperlipidemia risk compared with that measured for patients without thalassemia and without any counterpart comorbidities. In subgroup analysis, the HRs of dementia increased, from 1.69 (95% CI=0.93-3.07) for those who had not undergone transfusion to 2.72 (95% CI=1.09-6.78) for those experienced transfusion compared with the no thalassemia cohort (p for trend<0.01). CONCLUSION: Our long-term cohort study result showed that thalassemia should be considered a crucial risk factor for developing dementia. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/26051928/Thalassemia_and_risk_of_dementia:_a_nationwide_population_based_retrospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(15)00180-6 DB - PRIME DP - Unbound Medicine ER -