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Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation.
Org Lett. 2015 Jun 19; 17(12):3018-21.OL

Abstract

Rhodium(III)-catalyzed double C-H activation involving N-directed ortho C-H activation and subsequent roll-over C-H activation of the heterocycle ring has been developed to form complex 7-azaindole derivatives in moderate to excellent yields. A broad scope of 7-azaindoles and internal alkynes has been demonstrated in this oxidative annulation reaction.

Authors+Show Affiliations

†Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. ‡Graduate School of the Chinese Academy of Sciences, Beijing 100049, China. §Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.§Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.§Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.†Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.§Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26053413

Citation

Li, Shuai-Shuai, et al. "Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes Via Double C-H Activation." Organic Letters, vol. 17, no. 12, 2015, pp. 3018-21.
Li SS, Wang CQ, Lin H, et al. Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation. Org Lett. 2015;17(12):3018-21.
Li, S. S., Wang, C. Q., Lin, H., Zhang, X. M., & Dong, L. (2015). Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation. Organic Letters, 17(12), 3018-21. https://doi.org/10.1021/acs.orglett.5b01228
Li SS, et al. Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes Via Double C-H Activation. Org Lett. 2015 Jun 19;17(12):3018-21. PubMed PMID: 26053413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation. AU - Li,Shuai-Shuai, AU - Wang,Cheng-Qi, AU - Lin,Hui, AU - Zhang,Xiao-Mei, AU - Dong,Lin, Y1 - 2015/06/08/ PY - 2015/6/9/entrez PY - 2015/6/9/pubmed PY - 2016/5/18/medline SP - 3018 EP - 21 JF - Organic letters JO - Org Lett VL - 17 IS - 12 N2 - Rhodium(III)-catalyzed double C-H activation involving N-directed ortho C-H activation and subsequent roll-over C-H activation of the heterocycle ring has been developed to form complex 7-azaindole derivatives in moderate to excellent yields. A broad scope of 7-azaindoles and internal alkynes has been demonstrated in this oxidative annulation reaction. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/26053413/Rhodium_III__Catalyzed_Oxidative_Annulation_of_7_Azaindoles_and_Alkynes_via_Double_C_H_Activation_ L2 - https://doi.org/10.1021/acs.orglett.5b01228 DB - PRIME DP - Unbound Medicine ER -