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Levonorgestrel-releasing intrauterine device use as an alternative to surgical therapy for uterine leiomyoma.
Clin Exp Obstet Gynecol. 2015; 42(2):224-7.CE

Abstract

OBJECTIVE

To evaluate the efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of leiomyoma related menorrhagia and to assess the effect of LNG-IUS on uterine, leiomyoma, and ovarian volume.

MATERIALS AND METHODS

In this prospective before and after study, LNG-IUS was inserted in 38 women with myoma-related menorrhagia. The patients were evaluated for serum levels of hemoglobin, hematocrit and uterine, leiomyoma, and ovarian volume at the time of insertion and at six months.

RESULTS

Significant reduction in the Pictorial Blood Loss Assessment Chart (PBAC) score and increases in serum hemoglobin levels and in amenorrhea was observed within three months. However, there was no statistically significant reduction in the myoma and uterine volume. Ovarian volume, also, did not changed significantly.

CONCLUSION

The use of LNG-IUS is effective in reducing menorrhagia associated with leiomyomas with improvement in hemoglobin levels and may be a simple and effective alternative to surgical treatment of leiomyoma-related abnormal uterine bleeding (AUB-L) without significant influence on the volume of leiomyoma and ovarian and uterine volume.

Authors

Senol T
No affiliation info available
Kahramanoglu I
No affiliation info available
Dogan Y
No affiliation info available
Baktiroglu M
No affiliation info available
Karateke A
No affiliation info available
Suer N
No affiliation info available

MeSH

AdultAmenorrheaFemaleHemoglobinsHumansIntrauterine DevicesIntrauterine Devices, MedicatedLeiomyomaLevonorgestrelMenorrhagiaMiddle AgedProspective StudiesUterine Neoplasms

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

26054124

Citation

Senol, T, et al. "Levonorgestrel-releasing Intrauterine Device Use as an Alternative to Surgical Therapy for Uterine Leiomyoma." Clinical and Experimental Obstetrics & Gynecology, vol. 42, no. 2, 2015, pp. 224-7.
Senol T, Kahramanoglu I, Dogan Y, et al. Levonorgestrel-releasing intrauterine device use as an alternative to surgical therapy for uterine leiomyoma. Clin Exp Obstet Gynecol. 2015;42(2):224-7.
Senol, T., Kahramanoglu, I., Dogan, Y., Baktiroglu, M., Karateke, A., & Suer, N. (2015). Levonorgestrel-releasing intrauterine device use as an alternative to surgical therapy for uterine leiomyoma. Clinical and Experimental Obstetrics & Gynecology, 42(2), 224-7.
Senol T, et al. Levonorgestrel-releasing Intrauterine Device Use as an Alternative to Surgical Therapy for Uterine Leiomyoma. Clin Exp Obstet Gynecol. 2015;42(2):224-7. PubMed PMID: 26054124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levonorgestrel-releasing intrauterine device use as an alternative to surgical therapy for uterine leiomyoma. AU - Senol,T, AU - Kahramanoglu,I, AU - Dogan,Y, AU - Baktiroglu,M, AU - Karateke,A, AU - Suer,N, PY - 2015/6/10/entrez PY - 2015/6/10/pubmed PY - 2015/8/13/medline SP - 224 EP - 7 JF - Clinical and experimental obstetrics & gynecology JO - Clin Exp Obstet Gynecol VL - 42 IS - 2 N2 - OBJECTIVE: To evaluate the efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of leiomyoma related menorrhagia and to assess the effect of LNG-IUS on uterine, leiomyoma, and ovarian volume. MATERIALS AND METHODS: In this prospective before and after study, LNG-IUS was inserted in 38 women with myoma-related menorrhagia. The patients were evaluated for serum levels of hemoglobin, hematocrit and uterine, leiomyoma, and ovarian volume at the time of insertion and at six months. RESULTS: Significant reduction in the Pictorial Blood Loss Assessment Chart (PBAC) score and increases in serum hemoglobin levels and in amenorrhea was observed within three months. However, there was no statistically significant reduction in the myoma and uterine volume. Ovarian volume, also, did not changed significantly. CONCLUSION: The use of LNG-IUS is effective in reducing menorrhagia associated with leiomyomas with improvement in hemoglobin levels and may be a simple and effective alternative to surgical treatment of leiomyoma-related abnormal uterine bleeding (AUB-L) without significant influence on the volume of leiomyoma and ovarian and uterine volume. SN - 0390-6663 UR - https://www.unboundmedicine.com/medline/citation/26054124/Levonorgestrel_releasing_intrauterine_device_use_as_an_alternative_to_surgical_therapy_for_uterine_leiomyoma_ DB - PRIME DP - Unbound Medicine ER -