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Structural brain correlates of associative memory in older adults.
Neuroimage 2015; 118:146-53N

Abstract

Associative memory involves binding two or more items into a coherent memory episode. Relative to memory for single items, associative memory declines greatly in aging. However, older individuals vary substantially in their ability to memorize associative information. Although functional studies link associative memory to the medial temporal lobe (MTL) and prefrontal cortex (PFC), little is known about how volumetric differences in MTL and PFC might contribute to individual differences in associative memory. We investigated regional gray-matter volumes related to individual differences in associative memory in a sample of healthy older adults (n=54; age=60years). To differentiate item from associative memory, participants intentionally learned face-scene picture pairs before performing a recognition task that included single faces, scenes, and face-scene pairs. Gray-matter volumes were analyzed using voxel-based morphometry region-of-interest (ROI) analyses. To examine volumetric differences specifically for associative memory, item memory was controlled for in the analyses. Behavioral results revealed large variability in associative memory that mainly originated from differences in false-alarm rates. Moreover, associative memory was independent of individuals' ability to remember single items. Older adults with better associative memory showed larger gray-matter volumes primarily in regions of the left and right lateral PFC. These findings provide evidence for the importance of PFC in intentional learning of associations, likely because of its involvement in organizational and strategic processes that distinguish older adults with good from those with poor associative memory.

Authors+Show Affiliations

Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden. Electronic address: nina.becker@mpib-berlin.mpg.de.Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.Department of Psychological Sciences, University of MO, USA.Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26054875

Citation

Becker, Nina, et al. "Structural Brain Correlates of Associative Memory in Older Adults." NeuroImage, vol. 118, 2015, pp. 146-53.
Becker N, Laukka EJ, Kalpouzos G, et al. Structural brain correlates of associative memory in older adults. Neuroimage. 2015;118:146-53.
Becker, N., Laukka, E. J., Kalpouzos, G., Naveh-Benjamin, M., Bäckman, L., & Brehmer, Y. (2015). Structural brain correlates of associative memory in older adults. NeuroImage, 118, pp. 146-53. doi:10.1016/j.neuroimage.2015.06.002.
Becker N, et al. Structural Brain Correlates of Associative Memory in Older Adults. Neuroimage. 2015;118:146-53. PubMed PMID: 26054875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural brain correlates of associative memory in older adults. AU - Becker,Nina, AU - Laukka,Erika J, AU - Kalpouzos,Grégoria, AU - Naveh-Benjamin,Moshe, AU - Bäckman,Lars, AU - Brehmer,Yvonne, Y1 - 2015/06/05/ PY - 2015/01/16/received PY - 2015/05/26/revised PY - 2015/06/02/accepted PY - 2015/6/10/entrez PY - 2015/6/10/pubmed PY - 2016/5/27/medline KW - Aging KW - Associative memory KW - Episodic memory KW - Gray matter KW - Inter-individual differences KW - VBM SP - 146 EP - 53 JF - NeuroImage JO - Neuroimage VL - 118 N2 - Associative memory involves binding two or more items into a coherent memory episode. Relative to memory for single items, associative memory declines greatly in aging. However, older individuals vary substantially in their ability to memorize associative information. Although functional studies link associative memory to the medial temporal lobe (MTL) and prefrontal cortex (PFC), little is known about how volumetric differences in MTL and PFC might contribute to individual differences in associative memory. We investigated regional gray-matter volumes related to individual differences in associative memory in a sample of healthy older adults (n=54; age=60years). To differentiate item from associative memory, participants intentionally learned face-scene picture pairs before performing a recognition task that included single faces, scenes, and face-scene pairs. Gray-matter volumes were analyzed using voxel-based morphometry region-of-interest (ROI) analyses. To examine volumetric differences specifically for associative memory, item memory was controlled for in the analyses. Behavioral results revealed large variability in associative memory that mainly originated from differences in false-alarm rates. Moreover, associative memory was independent of individuals' ability to remember single items. Older adults with better associative memory showed larger gray-matter volumes primarily in regions of the left and right lateral PFC. These findings provide evidence for the importance of PFC in intentional learning of associations, likely because of its involvement in organizational and strategic processes that distinguish older adults with good from those with poor associative memory. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/26054875/Structural_brain_correlates_of_associative_memory_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(15)00478-4 DB - PRIME DP - Unbound Medicine ER -