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Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment.
J Oral Pathol Med. 2016 Jan; 45(1):35-40.JO

Abstract

OBJECTIVES

Oral lichen planus (OLP) is an inflammatory disease with an unknown origin. Oxidative stress is suspected to play a role in its pathogenesis. The aim of this study was to evaluate serum levels of oxidative stress factors and C-reactive protein in patients with OLP.

MATERIALS & METHODS

In this case-control study, 25 patients with OLP and 23 control subjects were enrolled. Serum levels of C-reactive protein (CRP), malondialdehyde (MDA), and total antioxidant capacity (TAC) were investigated in both groups. In case group, all these factors were re-evaluated after 14 days of treatment. The characteristics of the lesions were also recorded at each visit.

RESULTS

Serum levels of MDA were significantly higher (P = 0.009), and TAC was significantly lower (P < 0.001) in patients with OLP. There were no significant differences between serum levels of TAC, CRP, and MDA in patients with OLP before and after treatment (P = 0.174, P = 0.556, P = 0.194, respectively). However, the difference in serum levels of TAC between erosive and atrophic patients with keratotic OLP was significant (P = 0.024).

CONCLUSION

We concluded patients with OLP have increased of serum MDA and the decrease of serum TAC compared with the healthy subjects, and 14-day treatment of OLP did not have any effect on serum levels of oxidative stress factors.

Authors+Show Affiliations

Surgical Oncology Research Center, Imam Reza hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.Oral and Maxillofacial Diseases Research Center, Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26058710

Citation

Hashemy, Seyed Isaac, et al. "Oxidative Stress Factors and C-reactive Protein in Patients With Oral Lichen Planus Before and 2 Weeks After Treatment." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 45, no. 1, 2016, pp. 35-40.
Hashemy SI, Gharaei S, Vasigh S, et al. Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment. J Oral Pathol Med. 2016;45(1):35-40.
Hashemy, S. I., Gharaei, S., Vasigh, S., Kargozar, S., Alirezaei, B., Keyhani, F. J., & Amirchaghmaghi, M. (2016). Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 45(1), 35-40. https://doi.org/10.1111/jop.12326
Hashemy SI, et al. Oxidative Stress Factors and C-reactive Protein in Patients With Oral Lichen Planus Before and 2 Weeks After Treatment. J Oral Pathol Med. 2016;45(1):35-40. PubMed PMID: 26058710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment. AU - Hashemy,Seyed Isaac, AU - Gharaei,Shideh, AU - Vasigh,Samaneh, AU - Kargozar,Sanaz, AU - Alirezaei,Banafsheh, AU - Keyhani,Fereshteh Jahed, AU - Amirchaghmaghi,Maryam, Y1 - 2015/06/08/ PY - 2015/04/09/accepted PY - 2015/6/11/entrez PY - 2015/6/11/pubmed PY - 2017/1/26/medline KW - C-reactive protein KW - malondialdehyde KW - oral lichen planus KW - oxidative stress KW - total antioxidant capacity SP - 35 EP - 40 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 45 IS - 1 N2 - OBJECTIVES: Oral lichen planus (OLP) is an inflammatory disease with an unknown origin. Oxidative stress is suspected to play a role in its pathogenesis. The aim of this study was to evaluate serum levels of oxidative stress factors and C-reactive protein in patients with OLP. MATERIALS & METHODS: In this case-control study, 25 patients with OLP and 23 control subjects were enrolled. Serum levels of C-reactive protein (CRP), malondialdehyde (MDA), and total antioxidant capacity (TAC) were investigated in both groups. In case group, all these factors were re-evaluated after 14 days of treatment. The characteristics of the lesions were also recorded at each visit. RESULTS: Serum levels of MDA were significantly higher (P = 0.009), and TAC was significantly lower (P < 0.001) in patients with OLP. There were no significant differences between serum levels of TAC, CRP, and MDA in patients with OLP before and after treatment (P = 0.174, P = 0.556, P = 0.194, respectively). However, the difference in serum levels of TAC between erosive and atrophic patients with keratotic OLP was significant (P = 0.024). CONCLUSION: We concluded patients with OLP have increased of serum MDA and the decrease of serum TAC compared with the healthy subjects, and 14-day treatment of OLP did not have any effect on serum levels of oxidative stress factors. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/26058710/Oxidative_stress_factors_and_C_reactive_protein_in_patients_with_oral_lichen_planus_before_and_2_weeks_after_treatment_ L2 - https://doi.org/10.1111/jop.12326 DB - PRIME DP - Unbound Medicine ER -