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Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm.
Hum Brain Mapp. 2015 Aug; 36(8):3179-93.HB

Abstract

OBJECTIVES

The role of context in pain-related extinction learning remains poorly understood. We analyzed the neural mechanisms underlying context-dependent extinction and renewal in a clinically relevant model of conditioned abdominal pain-related fear.

EXPERIMENTAL DESIGN

In this functional magnetic resonance imaging study, two groups of healthy volunteers underwent differential fear conditioning with painful rectal distensions as unconditioned stimuli (US) and visual conditioned stimuli (CS(+) ; CS(-)). The extinction context was changed in an experimental group (context group), which was subsequently returned into the original learning context to test for renewal. No context changes occurred in the control group. Group differences in CS-induced differential neural activation were analyzed along with skin conductance responses (SCR), CS valence and CS-US contingency ratings.

PRINCIPAL OBSERVATIONS

During extinction, group differences in differential neural activation were observed in dorsolateral (dlPFC) and ventromedial (vmPFC) prefrontal cortex and amygdala, mainly driven by enhanced activation in response to the CS(-) in the control group. During renewal, observed group differences in activation of dlPFC and orbitofrontal cortex (OFC) resulted primarily from differential modulation of the CS(-) in the absence of group differences in response to CS(+) or SCR.

CONCLUSION

The extinction context affects the neural processing of nonpain predictive safety cues, supporting a role of safety learning in pain-related memory processes.

Authors+Show Affiliations

Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Department of Biological and Clinical Psychology, University of Trier, Trier, Germany.Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.Institute of Medical Psychology & Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26058893

Citation

Icenhour, Adriane, et al. "Neural Circuitry Underlying Effects of Context On Human Pain-related Fear Extinction in a Renewal Paradigm." Human Brain Mapping, vol. 36, no. 8, 2015, pp. 3179-93.
Icenhour A, Kattoor J, Benson S, et al. Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm. Hum Brain Mapp. 2015;36(8):3179-93.
Icenhour, A., Kattoor, J., Benson, S., Boekstegers, A., Schlamann, M., Merz, C. J., Forsting, M., & Elsenbruch, S. (2015). Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm. Human Brain Mapping, 36(8), 3179-93. https://doi.org/10.1002/hbm.22837
Icenhour A, et al. Neural Circuitry Underlying Effects of Context On Human Pain-related Fear Extinction in a Renewal Paradigm. Hum Brain Mapp. 2015;36(8):3179-93. PubMed PMID: 26058893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural circuitry underlying effects of context on human pain-related fear extinction in a renewal paradigm. AU - Icenhour,Adriane, AU - Kattoor,Joswin, AU - Benson,Sven, AU - Boekstegers,Armgard, AU - Schlamann,Marc, AU - Merz,Christian J, AU - Forsting,Michael, AU - Elsenbruch,Sigrid, Y1 - 2015/06/09/ PY - 2014/10/14/received PY - 2015/04/20/revised PY - 2015/04/27/accepted PY - 2015/6/11/entrez PY - 2015/6/11/pubmed PY - 2016/4/5/medline KW - brain imaging KW - extinction learning KW - fMRI KW - fear conditioning KW - renewal effect KW - visceral pain SP - 3179 EP - 93 JF - Human brain mapping JO - Hum Brain Mapp VL - 36 IS - 8 N2 - OBJECTIVES: The role of context in pain-related extinction learning remains poorly understood. We analyzed the neural mechanisms underlying context-dependent extinction and renewal in a clinically relevant model of conditioned abdominal pain-related fear. EXPERIMENTAL DESIGN: In this functional magnetic resonance imaging study, two groups of healthy volunteers underwent differential fear conditioning with painful rectal distensions as unconditioned stimuli (US) and visual conditioned stimuli (CS(+) ; CS(-)). The extinction context was changed in an experimental group (context group), which was subsequently returned into the original learning context to test for renewal. No context changes occurred in the control group. Group differences in CS-induced differential neural activation were analyzed along with skin conductance responses (SCR), CS valence and CS-US contingency ratings. PRINCIPAL OBSERVATIONS: During extinction, group differences in differential neural activation were observed in dorsolateral (dlPFC) and ventromedial (vmPFC) prefrontal cortex and amygdala, mainly driven by enhanced activation in response to the CS(-) in the control group. During renewal, observed group differences in activation of dlPFC and orbitofrontal cortex (OFC) resulted primarily from differential modulation of the CS(-) in the absence of group differences in response to CS(+) or SCR. CONCLUSION: The extinction context affects the neural processing of nonpain predictive safety cues, supporting a role of safety learning in pain-related memory processes. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/26058893/Neural_circuitry_underlying_effects_of_context_on_human_pain_related_fear_extinction_in_a_renewal_paradigm_ L2 - https://doi.org/10.1002/hbm.22837 DB - PRIME DP - Unbound Medicine ER -