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Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues.
Biomed Chromatogr. 2015 Dec; 29(12):1834-41.BC

Abstract

Salbutamol (SAL) is the most widely used β2 -agonist drug for asthma and chronic obstructive pulmonary patients, but it is also often abused as feed additive. In recent years, the abuse of SAL has led to a large number of food safety incidents. Therefore, the monitoring of SAL residues in animal products is very important. A highly selective boronate affinity magnetic adsorbent was synthesized and developed for detection of trace levels of SAL residues in pig tissue samples. The obtained Fe3O4@SiO2@FPBA(4-formylphenylboronic acid) magnetic adsorbent showed good adsorption ability to catechol and SAL, and then it was successfully applied as special magnetic solid-phase phase extraction adsorbent coupled with high-performance liquid chromatography (HPLC) for simultaneous isolation and determination of cis-diol compounds. The binding capacity of catechol and SAL reached 96 and 50 µmol/g, respectively. The method was successfully established for the detection of trace levels of SAL in pig tissue samples. The linear range extended from 0.32 to 800 µg/kg (R(2) = 0.9994). The limit of detection of SAL was 0.19 µg/kg. The recoveries were satisfactory (89.5-108.0%) at three spiked levels with RSD between 2.1 and 11.3%. These results indicated that the method has potential for enrichment and detection of trace levels of SAL residual in animal food products.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Fan H
Key Laboratory of Synthetic and Natural Function Molecule Chemistry of Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, 710127, People's Republic of China.
Wang C
Key Laboratory of Synthetic and Natural Function Molecule Chemistry of Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, 710127, People's Republic of China.
Wei Y
Key Laboratory of Synthetic and Natural Function Molecule Chemistry of Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, 710127, People's Republic of China.

MeSH

AlbuterolAnimalsBoronic AcidsChromatography, High Pressure LiquidDrug ResiduesLimit of DetectionLinear ModelsMagnetsMeatReproducibility of ResultsSolid Phase ExtractionSwine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26061980

Citation

Fan, Hua, et al. "Synthesis and Application of Boronic Acid-functionalized Magnetic Adsorbent for Sensitive Analysis of Salbutamol Residues in Pig Tissues." Biomedical Chromatography : BMC, vol. 29, no. 12, 2015, pp. 1834-41.
Fan H, Wang C, Wei Y. Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues. Biomed Chromatogr. 2015;29(12):1834-41.
Fan, H., Wang, C., & Wei, Y. (2015). Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues. Biomedical Chromatography : BMC, 29(12), 1834-41. https://doi.org/10.1002/bmc.3504
Fan H, Wang C, Wei Y. Synthesis and Application of Boronic Acid-functionalized Magnetic Adsorbent for Sensitive Analysis of Salbutamol Residues in Pig Tissues. Biomed Chromatogr. 2015;29(12):1834-41. PubMed PMID: 26061980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues. AU - Fan,Hua, AU - Wang,Chaozhan, AU - Wei,Yinmao, Y1 - 2015/06/10/ PY - 2014/12/22/received PY - 2015/04/24/revised PY - 2015/05/01/accepted PY - 2015/6/11/entrez PY - 2015/6/11/pubmed PY - 2016/5/19/medline KW - HPLC-UV KW - MSPE KW - SAL residual KW - boronic acid affinity KW - six-member covalent cyclic esters SP - 1834 EP - 41 JF - Biomedical chromatography : BMC JO - Biomed Chromatogr VL - 29 IS - 12 N2 - Salbutamol (SAL) is the most widely used β2 -agonist drug for asthma and chronic obstructive pulmonary patients, but it is also often abused as feed additive. In recent years, the abuse of SAL has led to a large number of food safety incidents. Therefore, the monitoring of SAL residues in animal products is very important. A highly selective boronate affinity magnetic adsorbent was synthesized and developed for detection of trace levels of SAL residues in pig tissue samples. The obtained Fe3O4@SiO2@FPBA(4-formylphenylboronic acid) magnetic adsorbent showed good adsorption ability to catechol and SAL, and then it was successfully applied as special magnetic solid-phase phase extraction adsorbent coupled with high-performance liquid chromatography (HPLC) for simultaneous isolation and determination of cis-diol compounds. The binding capacity of catechol and SAL reached 96 and 50 µmol/g, respectively. The method was successfully established for the detection of trace levels of SAL in pig tissue samples. The linear range extended from 0.32 to 800 µg/kg (R(2) = 0.9994). The limit of detection of SAL was 0.19 µg/kg. The recoveries were satisfactory (89.5-108.0%) at three spiked levels with RSD between 2.1 and 11.3%. These results indicated that the method has potential for enrichment and detection of trace levels of SAL residual in animal food products. SN - 1099-0801 UR - https://www.unboundmedicine.com/medline/citation/26061980/Synthesis_and_application_of_boronic_acid_functionalized_magnetic_adsorbent_for_sensitive_analysis_of_salbutamol_residues_in_pig_tissues_ DB - PRIME DP - Unbound Medicine ER -
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