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Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations with Parent- and Teacher-Rated Symptoms in Children with Attention-Deficit Hyperactivity Disorder.
Biol Trace Elem Res 2016; 169(1):1-7BT

Abstract

Attention-deficit hyperactivity disorder (ADHD) is associated with alterations in the metabolism of some trace elements which may participate in the pathogenesis of this disorder. The aims of the present study were to investigate the trace element status (copper (Cu), zinc (Zn), copper to zinc ratio (Cu/Zn ratio), selenium (Se), and lead (Pb)) of ADHD children and compare them with the control group. Associations between examined elements and ratings of ADHD symptoms were also assessed. Fifty-eight ADHD children and 50 healthy children (aged 6-14 years) were included in the study. The concentrations of Cu, Zn, and Se in the plasma and Pb in the whole blood were measured by atomic absorption spectrometry. We found lower Zn level (p = 0.0005) and higher Cu/Zn ratio (p = 0.015) in ADHD children when compared with the control group. Copper levels in ADHD children were higher than those in the control group, but not significantly (p > 0.05). No significant differences in levels of Se and Pb between both groups were found. Zinc levels correlated with parent-rated score for inattention (r = -0.231, p = 0.029) as well as with teacher-rated score for inattention (r = -0.328, p = 0.014). Cu/Zn ratio correlated with teacher-rated score for inattention (r = 0.298, p = 0.015). Significant associations of Se and Pb with parent- and teacher-rated symptoms were not observed. The results of this study indicate that there are alterations in plasma levels of Cu and Zn as well as significant relationships to symptoms of ADHD.

Authors+Show Affiliations

Institute of Medical Chemistry, Biochemistry, and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovak Republic. alena.viktorinova@fmed.uniba.sk.Laboratory of Toxic and Essential Elements, Department of Environmental Medicine, Slovak Medical University, Bratislava, Slovak Republic.Department of Pediatric Psychiatry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.Laboratory of Toxic and Essential Elements, Department of Environmental Medicine, Slovak Medical University, Bratislava, Slovak Republic.Institute of Medical Chemistry, Biochemistry, and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovak Republic.Laboratory of Toxic and Essential Elements, Department of Environmental Medicine, Slovak Medical University, Bratislava, Slovak Republic.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26063047

Citation

Viktorinova, Alena, et al. "Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations With Parent- and Teacher-Rated Symptoms in Children With Attention-Deficit Hyperactivity Disorder." Biological Trace Element Research, vol. 169, no. 1, 2016, pp. 1-7.
Viktorinova A, Ursinyova M, Trebaticka J, et al. Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations with Parent- and Teacher-Rated Symptoms in Children with Attention-Deficit Hyperactivity Disorder. Biol Trace Elem Res. 2016;169(1):1-7.
Viktorinova, A., Ursinyova, M., Trebaticka, J., Uhnakova, I., Durackova, Z., & Masanova, V. (2016). Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations with Parent- and Teacher-Rated Symptoms in Children with Attention-Deficit Hyperactivity Disorder. Biological Trace Element Research, 169(1), pp. 1-7. doi:10.1007/s12011-015-0395-3.
Viktorinova A, et al. Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations With Parent- and Teacher-Rated Symptoms in Children With Attention-Deficit Hyperactivity Disorder. Biol Trace Elem Res. 2016;169(1):1-7. PubMed PMID: 26063047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changed Plasma Levels of Zinc and Copper to Zinc Ratio and Their Possible Associations with Parent- and Teacher-Rated Symptoms in Children with Attention-Deficit Hyperactivity Disorder. AU - Viktorinova,Alena, AU - Ursinyova,Monika, AU - Trebaticka,Jana, AU - Uhnakova,Iveta, AU - Durackova,Zdenka, AU - Masanova,Vlasta, Y1 - 2015/06/12/ PY - 2015/03/10/received PY - 2015/06/01/accepted PY - 2015/6/12/entrez PY - 2015/6/13/pubmed PY - 2016/9/27/medline KW - Copper KW - Copper to zinc ratio KW - Oxidative stress KW - Trace element status KW - Zinc SP - 1 EP - 7 JF - Biological trace element research JO - Biol Trace Elem Res VL - 169 IS - 1 N2 - Attention-deficit hyperactivity disorder (ADHD) is associated with alterations in the metabolism of some trace elements which may participate in the pathogenesis of this disorder. The aims of the present study were to investigate the trace element status (copper (Cu), zinc (Zn), copper to zinc ratio (Cu/Zn ratio), selenium (Se), and lead (Pb)) of ADHD children and compare them with the control group. Associations between examined elements and ratings of ADHD symptoms were also assessed. Fifty-eight ADHD children and 50 healthy children (aged 6-14 years) were included in the study. The concentrations of Cu, Zn, and Se in the plasma and Pb in the whole blood were measured by atomic absorption spectrometry. We found lower Zn level (p = 0.0005) and higher Cu/Zn ratio (p = 0.015) in ADHD children when compared with the control group. Copper levels in ADHD children were higher than those in the control group, but not significantly (p > 0.05). No significant differences in levels of Se and Pb between both groups were found. Zinc levels correlated with parent-rated score for inattention (r = -0.231, p = 0.029) as well as with teacher-rated score for inattention (r = -0.328, p = 0.014). Cu/Zn ratio correlated with teacher-rated score for inattention (r = 0.298, p = 0.015). Significant associations of Se and Pb with parent- and teacher-rated symptoms were not observed. The results of this study indicate that there are alterations in plasma levels of Cu and Zn as well as significant relationships to symptoms of ADHD. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/26063047/Changed_Plasma_Levels_of_Zinc_and_Copper_to_Zinc_Ratio_and_Their_Possible_Associations_with_Parent__and_Teacher_Rated_Symptoms_in_Children_with_Attention_Deficit_Hyperactivity_Disorder_ L2 - https://dx.doi.org/10.1007/s12011-015-0395-3 DB - PRIME DP - Unbound Medicine ER -