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Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend on the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients with Partial Globozoospermia.
Chin Med J (Engl). 2015 Jun 20; 128(12):1590-5.CM

Abstract

BACKGROUND

Generally, intracytoplasmic sperm injection (ICSI) may be the preferable method to treat partial globozoospermia, but whether there exist some correlations between ICSI fertilization rate and the proportion of round-headed sperm or morphologically normal sperm remains open. This study was to explore the correlation between ICSI fertilization rate and the sperm morphology in patients with partial globozoospermia.

METHODS

Thirty-four patients diagnosed with partial globozoospermia accepted the following assisted fertilization treatments - 2 cases accepted in-vitro fertilization (IVF) alone, 26 cases accepted ICSI alone, and 6 accepted split IVF/ICSI. Detailed morphological characteristics were described using Diff-Quik rapid staining. Sixty cases accepting IVF or ICSI treatment in our reproductive center were considered as the control group after being matched by relevant criteria. Fertilization rate, embryo quality, embryo implantation rate and clinical pregnancy rate were calculated.

RESULTS

Besides very high proportion of round-headed sperm, partial globozoospermia also showed very high proportion of small-acrosomal sperm and very low proportion of morphologically normal sperm. Fertilization rate of IVF (IVF alone plus split IVF) was very low in partial globozoospermia (25.4% ± 17.4%), but ICSI (ICSI alone plus split ICSI) achieved satisfying fertilization rate compared with the control group (66.2% ± 22.5% vs. 68.8% ± 29.4%, P > 0.05). In patients with partial globozoospermia, there were no correlations between ICSI fertilization rate and the proportion of round-headed sperm, small-acrosomal sperm, or morphologically normal sperm.

CONCLUSIONS

There was high proportion of small-acrosomal sperm in partial globozoospermia. For patients with partial globozoospermia, ICSI is more preferable than IVF. ICSI fertilization rate does not depend on the proportion of round-headed sperm, small-acrosomal sperm, or morphologically normal sperm.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26063359

Citation

Jiang, Ling-Ying, et al. "Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend On the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients With Partial Globozoospermia." Chinese Medical Journal, vol. 128, no. 12, 2015, pp. 1590-5.
Jiang LY, Yang LY, Tong XM, et al. Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend on the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients with Partial Globozoospermia. Chin Med J. 2015;128(12):1590-5.
Jiang, L. Y., Yang, L. Y., Tong, X. M., Zhu, H. Y., Xue, Y. M., Xu, W. Z., Yang, Y., & Zhang, S. Y. (2015). Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend on the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients with Partial Globozoospermia. Chinese Medical Journal, 128(12), 1590-5. https://doi.org/10.4103/0366-6999.158310
Jiang LY, et al. Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend On the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients With Partial Globozoospermia. Chin Med J. 2015 Jun 20;128(12):1590-5. PubMed PMID: 26063359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracytoplasmic Sperm Injection Fertilization Rate Does Not Depend on the Proportion of Round-headed Sperm, Small-acrosomal Sperm, or Morphologically Normal Sperm in Patients with Partial Globozoospermia. AU - Jiang,Ling-Ying, AU - Yang,Ling-Yun, AU - Tong,Xiao-Mei, AU - Zhu,Hai-Yan, AU - Xue,Ya-Mei, AU - Xu,Wen-Zhi, AU - Yang,Yang, AU - Zhang,Song-Ying, PY - 2015/6/12/entrez PY - 2015/6/13/pubmed PY - 2016/3/16/medline SP - 1590 EP - 5 JF - Chinese medical journal JO - Chin. Med. J. VL - 128 IS - 12 N2 - BACKGROUND: Generally, intracytoplasmic sperm injection (ICSI) may be the preferable method to treat partial globozoospermia, but whether there exist some correlations between ICSI fertilization rate and the proportion of round-headed sperm or morphologically normal sperm remains open. This study was to explore the correlation between ICSI fertilization rate and the sperm morphology in patients with partial globozoospermia. METHODS: Thirty-four patients diagnosed with partial globozoospermia accepted the following assisted fertilization treatments - 2 cases accepted in-vitro fertilization (IVF) alone, 26 cases accepted ICSI alone, and 6 accepted split IVF/ICSI. Detailed morphological characteristics were described using Diff-Quik rapid staining. Sixty cases accepting IVF or ICSI treatment in our reproductive center were considered as the control group after being matched by relevant criteria. Fertilization rate, embryo quality, embryo implantation rate and clinical pregnancy rate were calculated. RESULTS: Besides very high proportion of round-headed sperm, partial globozoospermia also showed very high proportion of small-acrosomal sperm and very low proportion of morphologically normal sperm. Fertilization rate of IVF (IVF alone plus split IVF) was very low in partial globozoospermia (25.4% ± 17.4%), but ICSI (ICSI alone plus split ICSI) achieved satisfying fertilization rate compared with the control group (66.2% ± 22.5% vs. 68.8% ± 29.4%, P > 0.05). In patients with partial globozoospermia, there were no correlations between ICSI fertilization rate and the proportion of round-headed sperm, small-acrosomal sperm, or morphologically normal sperm. CONCLUSIONS: There was high proportion of small-acrosomal sperm in partial globozoospermia. For patients with partial globozoospermia, ICSI is more preferable than IVF. ICSI fertilization rate does not depend on the proportion of round-headed sperm, small-acrosomal sperm, or morphologically normal sperm. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/26063359/Intracytoplasmic_Sperm_Injection_Fertilization_Rate_Does_Not_Depend_on_the_Proportion_of_Round_headed_Sperm_Small_acrosomal_Sperm_or_Morphologically_Normal_Sperm_in_Patients_with_Partial_Globozoospermia_ L2 - http://dx.doi.org/10.4103/0366-6999.158310 DB - PRIME DP - Unbound Medicine ER -