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Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus.
J Virol. 2015 Sep; 89(17):9119-23.JV

Abstract

To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV infects human cells. These mutations therefore played critical roles in the bat-to-human transmission of MERS-CoV, either directly or through intermediate hosts.

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Authors+Show Affiliations

Yang Y
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Liu C
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Du L
Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Jiang S
Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
Shi Z
Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Baric RS
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Li F
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA lifang@umn.edu.

MeSH

AnimalsCell LineChiropteraCoronavirus InfectionsDipeptidyl Peptidase 4HumansMiddle East Respiratory Syndrome CoronavirusMutationReceptors, VirusViral Structural Proteins

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26063432

Citation

Yang, Yang, et al. "Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus." Journal of Virology, vol. 89, no. 17, 2015, pp. 9119-23.
Yang Y, Liu C, Du L, et al. Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. J Virol. 2015;89(17):9119-23.
Yang, Y., Liu, C., Du, L., Jiang, S., Shi, Z., Baric, R. S., & Li, F. (2015). Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. Journal of Virology, 89(17), 9119-23. https://doi.org/10.1128/JVI.01279-15
Yang Y, et al. Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. J Virol. 2015;89(17):9119-23. PubMed PMID: 26063432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. AU - Yang,Yang, AU - Liu,Chang, AU - Du,Lanying, AU - Jiang,Shibo, AU - Shi,Zhengli, AU - Baric,Ralph S, AU - Li,Fang, Y1 - 2015/06/10/ PY - 2015/05/15/received PY - 2015/06/07/accepted PY - 2015/6/12/entrez PY - 2015/6/13/pubmed PY - 2016/4/30/medline SP - 9119 EP - 23 JF - Journal of virology JO - J Virol VL - 89 IS - 17 N2 - To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explaining why MERS-CoV infects human cells. These mutations therefore played critical roles in the bat-to-human transmission of MERS-CoV, either directly or through intermediate hosts. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/26063432/Two_Mutations_Were_Critical_for_Bat_to_Human_Transmission_of_Middle_East_Respiratory_Syndrome_Coronavirus_ DB - PRIME DP - Unbound Medicine ER -