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Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.
J Immunol Res. 2015; 2015:450391.JI

Abstract

Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies. We found that the clinical picture in these patients is highly variable suggesting a direct link between the monoclonal gammopathy and the neuropathy. Conversely, one-third of patients had a CIDP-like phenotype on electrodiagnostic testing and this was correlated with a low titer of anti-MAG antibodies and the absence of widening of myelin lamellae. Our data suggest that polyneuropathy associated with anti-MAG antibodies is less homogeneous than previously said and that the pathophysiology of the condition is likely to be heterogeneous as well with the self-antigen being MAG in most of the patients but possibly being another component of myelin in the others.

Authors+Show Affiliations

Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France.Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France.Department of Neurology, CHU Poitiers, University of Poitiers, 2 Rue de la Milétrie, 86021 Poitiers, France.Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France.Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France.Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 69000 Lyon, France.Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26065001

Citation

Magy, Laurent, et al. "Heterogeneity of Polyneuropathy Associated With Anti-MAG Antibodies." Journal of Immunology Research, vol. 2015, 2015, p. 450391.
Magy L, Kaboré R, Mathis S, et al. Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies. J Immunol Res. 2015;2015:450391.
Magy, L., Kaboré, R., Mathis, S., Lebeau, P., Ghorab, K., Caudie, C., & Vallat, J. M. (2015). Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies. Journal of Immunology Research, 2015, 450391. https://doi.org/10.1155/2015/450391
Magy L, et al. Heterogeneity of Polyneuropathy Associated With Anti-MAG Antibodies. J Immunol Res. 2015;2015:450391. PubMed PMID: 26065001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies. AU - Magy,Laurent, AU - Kaboré,Raphaël, AU - Mathis,Stéphane, AU - Lebeau,Prisca, AU - Ghorab,Karima, AU - Caudie,Christiane, AU - Vallat,Jean-Michel, Y1 - 2015/05/06/ PY - 2014/11/04/received PY - 2015/04/07/accepted PY - 2015/6/12/entrez PY - 2015/6/13/pubmed PY - 2016/3/5/medline SP - 450391 EP - 450391 JF - Journal of immunology research JO - J Immunol Res VL - 2015 N2 - Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies. We found that the clinical picture in these patients is highly variable suggesting a direct link between the monoclonal gammopathy and the neuropathy. Conversely, one-third of patients had a CIDP-like phenotype on electrodiagnostic testing and this was correlated with a low titer of anti-MAG antibodies and the absence of widening of myelin lamellae. Our data suggest that polyneuropathy associated with anti-MAG antibodies is less homogeneous than previously said and that the pathophysiology of the condition is likely to be heterogeneous as well with the self-antigen being MAG in most of the patients but possibly being another component of myelin in the others. SN - 2314-7156 UR - https://www.unboundmedicine.com/medline/citation/26065001/Heterogeneity_of_Polyneuropathy_Associated_with_Anti_MAG_Antibodies_ L2 - https://dx.doi.org/10.1155/2015/450391 DB - PRIME DP - Unbound Medicine ER -