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Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial.
Biol Trace Elem Res. 2016 Jan; 169(1):8-16.BT

Abstract

The study aimed to investigate the effect of oral zinc supplementation on antioxidant defenses and oxidative stress markers during chemotherapy for colorectal cancer. Twenty-four patients who had undergone surgical resection of colorectal cancer participated in this placebo-controlled, prospective randomized study. The supplementation was started in the perioperative period, in which 10 patients received 70 mg of zinc (zinc group, n = 10) and 14 patients received placebo (placebo group, n = 14) for 16 weeks. Approximately 45 days after surgical resection of tumor, all patients received a chemotherapeutic regimen (capecitabine, capecitabine combined with oxaliplatin or 5-fluorouracil). Vitamin C, vitamin E, antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), and lipid peroxidation markers malondialdehyde (MDA) and 8-isoprostane were determined before the first, second, third, and fourth chemotherapy cycles. Compared with the placebo group, the zinc group presented higher SOD values before the first, second, and fourth chemotherapy cycles and lower GPx values before the third cycle. There were no statistical differences between the study groups in vitamin C, vitamin E, MDA, or 8-isoprostane plasma values. Longitudinal analysis revealed decreased vitamin E concentration in the placebo group before the second and fourth cycles as compared with the initial values. Zinc supplementation during chemotherapy cycles increased SOD activity and maintained vitamin E concentrations. Although no effect of zinc supplementation on oxidative stress markers was observed, the increase in SOD activity indicates a production of stable free radicals, which may have a positive effect in cancer treatment.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ribeiro SM
Division of Nutrology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Braga CB
Division of Nutrology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Peria FM
Division of Clinical Oncology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Domenici FA
Division of Nutrology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Martinez EZ
Department of Social Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Feres O
Department of Surgery, School of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
da Rocha JJ
Department of Surgery, School of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
da Cunha SF
Division of Nutrology, Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. sfreire@fmrp.usp.br.

MeSH

AgedAntioxidantsColorectal NeoplasmsDietary SupplementsFemaleGlutathione PeroxidaseHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxidation-ReductionOxidative StressZinc

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26066525

Citation

Ribeiro, Sofia Miranda de Figueiredo, et al. "Effect of Zinc Supplementation On Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial." Biological Trace Element Research, vol. 169, no. 1, 2016, pp. 8-16.
Ribeiro SM, Braga CB, Peria FM, et al. Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial. Biol Trace Elem Res. 2016;169(1):8-16.
Ribeiro, S. M., Braga, C. B., Peria, F. M., Domenici, F. A., Martinez, E. Z., Feres, O., da Rocha, J. J., & da Cunha, S. F. (2016). Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial. Biological Trace Element Research, 169(1), 8-16. https://doi.org/10.1007/s12011-015-0396-2
Ribeiro SM, et al. Effect of Zinc Supplementation On Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial. Biol Trace Elem Res. 2016;169(1):8-16. PubMed PMID: 26066525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial. AU - Ribeiro,Sofia Miranda de Figueiredo, AU - Braga,Camila Bitu Moreno, AU - Peria,Fernanda Maris, AU - Domenici,Fernanda Aparecida, AU - Martinez,Edson Zangiacomi, AU - Feres,Omar, AU - da Rocha,José Joaquim Ribeiro, AU - da Cunha,Selma Freire de Carvalho, Y1 - 2015/06/12/ PY - 2015/03/06/received PY - 2015/06/02/accepted PY - 2015/6/13/entrez PY - 2015/6/13/pubmed PY - 2016/9/27/medline KW - Antioxidant KW - Chemotherapy KW - Colorectal cancer KW - Oxidative stress KW - Zinc SP - 8 EP - 16 JF - Biological trace element research JO - Biol Trace Elem Res VL - 169 IS - 1 N2 - The study aimed to investigate the effect of oral zinc supplementation on antioxidant defenses and oxidative stress markers during chemotherapy for colorectal cancer. Twenty-four patients who had undergone surgical resection of colorectal cancer participated in this placebo-controlled, prospective randomized study. The supplementation was started in the perioperative period, in which 10 patients received 70 mg of zinc (zinc group, n = 10) and 14 patients received placebo (placebo group, n = 14) for 16 weeks. Approximately 45 days after surgical resection of tumor, all patients received a chemotherapeutic regimen (capecitabine, capecitabine combined with oxaliplatin or 5-fluorouracil). Vitamin C, vitamin E, antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), and lipid peroxidation markers malondialdehyde (MDA) and 8-isoprostane were determined before the first, second, third, and fourth chemotherapy cycles. Compared with the placebo group, the zinc group presented higher SOD values before the first, second, and fourth chemotherapy cycles and lower GPx values before the third cycle. There were no statistical differences between the study groups in vitamin C, vitamin E, MDA, or 8-isoprostane plasma values. Longitudinal analysis revealed decreased vitamin E concentration in the placebo group before the second and fourth cycles as compared with the initial values. Zinc supplementation during chemotherapy cycles increased SOD activity and maintained vitamin E concentrations. Although no effect of zinc supplementation on oxidative stress markers was observed, the increase in SOD activity indicates a production of stable free radicals, which may have a positive effect in cancer treatment. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/26066525/Effect_of_Zinc_Supplementation_on_Antioxidant_Defenses_and_Oxidative_Stress_Markers_in_Patients_Undergoing_Chemotherapy_for_Colorectal_Cancer:_a_Placebo_Controlled_Prospective_Randomized_Trial_ DB - PRIME DP - Unbound Medicine ER -