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Remote ischaemic preconditioning in intermittent claudication.
Arch Cardiovasc Dis. 2015 Oct; 108(10):472-9.AC

Abstract

BACKGROUND

Remote ischaemic preconditioning (RIPC) protects tissues against ischaemia-reperfusion (I/R) injury, a common occurrence in several clinical settings.

AIMS

To evaluate whether RIPC has a beneficial impact on walking disability in arterial intermittent claudication.

METHODS

A total of 20 patients with proven intermittent claudication underwent two treadmill walking tests with a 7-day interval in between; they were randomized according to the order in which they received either RIPC or a control procedure before the first treadmill test, with a crossover at the second test. Patients received three cycles of alternating 5-minute inflation and 5-minute deflation of blood-pressure cuffs on both arms, with inflation to a pressure of 200 mmHg in the RIPC procedure or 10mmHg in the control procedure. Walking distances and limb oxygenation data, assessed with transcutaneous oximetry and near infrared spectroscopy measurements, were obtained during both RIPC and control procedures in all patients.

RESULTS

Similar exercise intensities were achieved after the control and RIPC procedures. Walking distances did not significantly differ after the control and RIPC procedures (204 [141-259]m vs 215 [162-442]m, respectively; P=0.22). Similarly, no difference was observed in terms of transcutaneous oxygen pressure change and near infrared spectroscopy measurements during exercise between the two procedures.

CONCLUSION

RIPC did not improve walking distance or limb ischaemia variables in patients with peripheral artery disease and intermittent claudication.

Authors+Show Affiliations

L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France.L'UNAM université, Nantes, France; Service d'explorations fonctionnelles vasculaires et centre régional de médicine du sport, CHU d'Angers, Angers, France; Inserm U771, CNRS UMR 6214, université d'Angers, Angers, France.L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France.L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France.L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France.L'UNAM université, Nantes, France; Service d'explorations fonctionnelles vasculaires et centre régional de médicine du sport, CHU d'Angers, Angers, France; Inserm U771, CNRS UMR 6214, université d'Angers, Angers, France.L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France. Electronic address: faprunier@chu-angers.fr.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26071836

Citation

Delagarde, Hermeland, et al. "Remote Ischaemic Preconditioning in Intermittent Claudication." Archives of Cardiovascular Diseases, vol. 108, no. 10, 2015, pp. 472-9.
Delagarde H, Ouadraougo N, Grall S, et al. Remote ischaemic preconditioning in intermittent claudication. Arch Cardiovasc Dis. 2015;108(10):472-9.
Delagarde, H., Ouadraougo, N., Grall, S., Macchi, L., Roy, P. M., Abraham, P., & Prunier, F. (2015). Remote ischaemic preconditioning in intermittent claudication. Archives of Cardiovascular Diseases, 108(10), 472-9. https://doi.org/10.1016/j.acvd.2015.03.004
Delagarde H, et al. Remote Ischaemic Preconditioning in Intermittent Claudication. Arch Cardiovasc Dis. 2015;108(10):472-9. PubMed PMID: 26071836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Remote ischaemic preconditioning in intermittent claudication. AU - Delagarde,Hermeland, AU - Ouadraougo,Nafi, AU - Grall,Sylvain, AU - Macchi,Laurent, AU - Roy,Pierre-Marie, AU - Abraham,Pierre, AU - Prunier,Fabrice, Y1 - 2015/06/10/ PY - 2015/01/19/received PY - 2015/02/27/revised PY - 2015/03/18/accepted PY - 2015/6/15/entrez PY - 2015/6/15/pubmed PY - 2016/8/3/medline KW - Artériopathie oblitérante des membres inférieurs KW - Conditionnement ischémique à distance KW - Ischaemia-reperfusion KW - Ischémie-reperfusion KW - Peripheral artery disease KW - Remote conditioning SP - 472 EP - 9 JF - Archives of cardiovascular diseases JO - Arch Cardiovasc Dis VL - 108 IS - 10 N2 - BACKGROUND: Remote ischaemic preconditioning (RIPC) protects tissues against ischaemia-reperfusion (I/R) injury, a common occurrence in several clinical settings. AIMS: To evaluate whether RIPC has a beneficial impact on walking disability in arterial intermittent claudication. METHODS: A total of 20 patients with proven intermittent claudication underwent two treadmill walking tests with a 7-day interval in between; they were randomized according to the order in which they received either RIPC or a control procedure before the first treadmill test, with a crossover at the second test. Patients received three cycles of alternating 5-minute inflation and 5-minute deflation of blood-pressure cuffs on both arms, with inflation to a pressure of 200 mmHg in the RIPC procedure or 10mmHg in the control procedure. Walking distances and limb oxygenation data, assessed with transcutaneous oximetry and near infrared spectroscopy measurements, were obtained during both RIPC and control procedures in all patients. RESULTS: Similar exercise intensities were achieved after the control and RIPC procedures. Walking distances did not significantly differ after the control and RIPC procedures (204 [141-259]m vs 215 [162-442]m, respectively; P=0.22). Similarly, no difference was observed in terms of transcutaneous oxygen pressure change and near infrared spectroscopy measurements during exercise between the two procedures. CONCLUSION: RIPC did not improve walking distance or limb ischaemia variables in patients with peripheral artery disease and intermittent claudication. SN - 1875-2128 UR - https://www.unboundmedicine.com/medline/citation/26071836/Remote_ischaemic_preconditioning_in_intermittent_claudication_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-2136(15)00073-X DB - PRIME DP - Unbound Medicine ER -